Zobrazeno 1 - 10
of 27
pro vyhledávání: '"I. E. Hughes"'
Autor:
I. E. Hughes, R. M. Hagan
Publikováno v:
Journal of Autonomic Pharmacology. 1:385-390
1 Electrical stimulation of mouse vasa deferentia or of rat occipital cortex slices which had been previously incubated with 3H-(-)noradrenaline increased the overflow of tritium from the tissue above that occurring spontaneously. 2 Phentolamine (10
Autor:
I. E. Hughes, Barbara Kneen
Publikováno v:
Journal of Pharmacy and Pharmacology. 28:200-205
(±)-Propranolol hydrochloride (0·5 mg kg−1 twice daily, subcutaneously, for 3 days or approximately 2·4 mg kg−1 daily, orally, for 21 days) failed to produce ptosis or to affect responses to transmural stimulation of isolated vasa deferentia r
Autor:
I E Hughes
Publikováno v:
Journal of Pharmacy and Pharmacology. 20:116-124
On the sciatic nerve-gastrocnemius-soleus muscle preparation of the cat, angiotensin (1–5 μg/kg, i.v.) potentiated the twitch response to maximal and submaximal stimulation of the sciatic nerve and produced partial reversal of an incomplete tubocu
Autor:
H. G. Dean, I. E. Hughes
Publikováno v:
Journal of Pharmacy and Pharmacology. 24:183-188
Although both NN-diethyl- and NN-dimethyl-, N-methyl-[14C]-2-(2,6-xylyloxy) ethylammonium iodide (14C-1DE10 iodide and 14C-TM10 iodide; xylocholine) are taken up by guinea-pig vas deferens to a similar extent in vitro, only TM10 reduced the response
Autor:
I. E. Hughes, E. R. Clark
Publikováno v:
British Journal of Pharmacology and Chemotherapy. 28:105-128
Autor:
I E Hughes, E R Clark
Publikováno v:
Journal of Pharmacy and Pharmacology. 22:279-283
Phosphocholine 2, 6-xylyl ether bromide [PPP-trimethyl-2-(2, 6-xylyloxy)ethylphosphonium bromide], has been synthesized by reacting 2-(2, 6-xylyloxy)ethyl bromide with a solution of trimethyl-phosphine in phenol, but ethylenebis(trimethylphosphonium
Publikováno v:
Chemischer Informationsdienst. 7
Autor:
I E, Hughes, S, Radman
Publikováno v:
British journal of clinical pharmacology. 5
1. Amitriptyline, imipramine, maprotiline and mianserin were administered intravenously to conscious rabbits. 2. Of the four compounds, mianserin was the least toxic, as assessed by the occurrence of convulsions, cardiotoxicity and eventual death. 3.
Autor:
J.A. Smith, I E Hughes
Publikováno v:
The Journal of pharmacy and pharmacology. 30(2)
Publikováno v:
Journal of medicinal chemistry. 19(5)
The synthesis of cis and trans isomers of N,N-N-trimethyl-2-phenoxycyclohexylammonium bromide, cis-N,N,-N-trimethyl-2(2',6'-xylyloxy)cyclohexylammonium bromide, and N,N-dimethyl-3-phenoxypiperidinium bromide is described. Their structures and conform