Zobrazeno 1 - 10 of 59 pro vyhledávání: '"I. Dreher"'
1
Akademický článek
Mesenchymal stromal cell chondrogenesis under ALK1/2/3-specific BMP inhibition: a revision of the prohypertrophic signalling network concept
Autor: Solvig Diederichs, Simon I. Dreher, Sarah Anna Nüesch, Sven Schmidt, Christian Merle, Wiltrud Richter
Publikováno v: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background In vitro chondrogenesis of mesenchymal stromal cells (MSCs) driven by the essential chondro-inducer transforming growth factor (TGF)-β is instable and yields undesired hypertrophic cartilage predisposed to bone formation in vivo.
Externí odkaz: https://doaj.org/article/c05f8ba30a654773992e8de861edb4b3
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2
Akademický článek
MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1
Autor: Svitlana Melnik, Jessica Gabler, Simon I. Dreher, Nicole Hecht, Nina Hofmann, Tobias Großner, Wiltrud Richter
Publikováno v: Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-18 (2020)
Abstract Background Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable occurrence of calcification after ectopic transplantation, known as hype
Externí odkaz: https://doaj.org/article/f0eecec0cb6e4cdeb16edcf683b0256e
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3
Akademický článek
Significance of MEF2C and RUNX3 Regulation for Endochondral Differentiation of Human Mesenchymal Progenitor Cells
Autor: Simon I. Dreher, Jennifer Fischer, Tilman Walker, Solvig Diederichs, Wiltrud Richter
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Guiding progenitor cell development between chondral versus endochondral pathways is still an unachieved task of cartilage neogenesis, and human mesenchymal progenitor cell (MPC) chondrogenesis is considered as a valuable model to better understand h
Externí odkaz: https://doaj.org/article/79ac17833fb94a86b94d6c8288125e03
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4
Akademický článek
TGF-β Induction of miR-143/145 Is Associated to Exercise Response by Influencing Differentiation and Insulin Signaling Molecules in Human Skeletal Muscle
Autor: Simon I. Dreher, Selina Höckele, Peter Huypens, Martin Irmler, Christoph Hoffmann, Tim Jeske, Maximilian Hastreiter, Anja Moller, Andreas L. Birkenfeld, Hans-Ulrich Häring, Andreas Peter, Johannes Beckers, Martin Hrabě de Angelis, Cora Weigert
Publikováno v: Cells, Vol 10, Iss 12, p 3443 (2021)
Physical training improves insulin sensitivity and can prevent type 2 diabetes (T2D). However, approximately 20% of individuals lack a beneficial outcome in glycemic control. TGF-β, identified as a possible upstream regulator involved in this low re
Externí odkaz: https://doaj.org/article/e7802b730a534fd0bc3a53e75827922f
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6
Akademický článek
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7
Akademický článek
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9
Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy
Autor: Andreas Geisbüsch, Veronika Tonnier, Solvig Diederichs, Simon I. Dreher, Wiltrud Richter, Melanie März
Publikováno v: Cellular and Molecular Life Sciences. 76:3875-3889
Re-directing mesenchymal stromal cell (MSC) chondrogenesis towards a non-hypertrophic articular chondrocyte-(AC)-like phenotype is important for improving articular cartilage neogenesis to enhance clinical cartilage repair strategies. This study is t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1615eb682dc64c9edc5c646e46c770ec
https://doi.org/10.1007/s00018-019-03099-0
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10
Immunotherapy of a squamous cell carcinoma in the perianal region using autologous dendritic cells in a horse
Autor: C Arnold, T. Grammel, G. F. Schusser, I. Dreher
Publikováno v: Equine Veterinary Education. 30:576-582
Summary A 23-year-old Trakehner mare was referred to the Department of Large Animal Medicine with an ulcerative cleft tumour dorsal of the anus and in poor body condition. An infiltrative growing squamous cell carcinoma (SCC) was diagnosed. Surgical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbca05e9621665738368cae53f74df21
https://doi.org/10.1111/eve.12741
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