Zobrazeno 1 - 10
of 16
pro vyhledávání: '"I. Deeg"'
Publikováno v:
BMC Oral Health, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Purpose Our study aimed to evaluate the long-term concordance and acceptance when using powered devices for everyday oral hygiene routine and gingival health in patients showing papillary bleeding. Patients and methods Thirty-one participant
Externí odkaz:
https://doaj.org/article/27eb7d1fb2ef45b48ab83d894888f52b
Autor:
Lars Feuerbach, Lina Sieverling, Katharina I. Deeg, Philip Ginsbach, Barbara Hutter, Ivo Buchhalter, Paul A. Northcott, Sadaf S. Mughal, Priya Chudasama, Hanno Glimm, Claudia Scholl, Peter Lichter, Stefan Fröhling, Stefan M. Pfister, David T. W. Jones, Karsten Rippe, Benedikt Brors
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Establishment of telomere maintenance mechanisms is a universal step in tumor development to achieve replicative immortality. These processes leave molecular footprints in cancer genomes in the form of altered telomere content and
Externí odkaz:
https://doaj.org/article/bb791c955efa49c28cf32dfc564d481a
Publikováno v:
BMC Genetics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery. Cancer cells need to counteract the shortening of telom
Externí odkaz:
https://doaj.org/article/0fea98f1f5b64f77ba74765fe71065c6
Autor:
Priya Chudasama, Sadaf S. Mughal, Mathijs A. Sanders, Daniel Hübschmann, Inn Chung, Katharina I. Deeg, Siao-Han Wong, Sophie Rabe, Mario Hlevnjak, Marc Zapatka, Aurélie Ernst, Kortine Kleinheinz, Matthias Schlesner, Lina Sieverling, Barbara Klink, Evelin Schröck, Remco M. Hoogenboezem, Bernd Kasper, Christoph E. Heilig, Gerlinde Egerer, Stephan Wolf, Christof von Kalle, Roland Eils, Albrecht Stenzinger, Wilko Weichert, Hanno Glimm, Stefan Gröschel, Hans-Georg Kopp, Georg Omlor, Burkhard Lehner, Sebastian Bauer, Simon Schimmack, Alexis Ulrich, Gunhild Mechtersheimer, Karsten Rippe, Benedikt Brors, Barbara Hutter, Marcus Renner, Peter Hohenberger, Claudia Scholl, Stefan Fröhling
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The molecular genetic landscape of leiomyosarcoma (LMS) is largely unknown. Here, the authors identify frequent DNA copy number alterations, whole-genome duplication, TP53 and RB1 inactivation, alternative telomere lengthening, and genomic imprints o
Externí odkaz:
https://doaj.org/article/d4d8c497353f4a34a7f3673b1d82cb28
Akademický článek
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Publikováno v:
Frontiers in Oncology, Vol 6 (2016)
Telomere maintenance is a hallmark of cancer as it provides cancer cells with cellular immortality. A significant fraction of tumors uses the alternative lengthening of telomeres (ALT) pathway to elongate their telomeres and to gain an unlimited prol
Externí odkaz:
https://doaj.org/article/caee669e6d2c40e0883491506e09ab9f
Autor:
Karsten Rippe, Benedikt Brors, Peter Lichter, Katharina I. Deeg, David T.W. Jones, Sadaf S. Mughal, Stefan Fröhling, Lina Sieverling, Barbara Hutter, Claudia Scholl, Hanno Glimm, Stefan M. Pfister, Paul A. Northcott, Priya Chudasama, Ivo Buchhalter, Lars Feuerbach, Philip Ginsbach
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)
Background Establishment of telomere maintenance mechanisms is a universal step in tumor development to achieve replicative immortality. These processes leave molecular footprints in cancer genomes in the form of altered telomere content and aberrati
Autor:
Billy Michael Chelliah Jebaraj, Kristian W. Pajtler, Jennifer Edelmann, Uri Tabori, Marcel Kool, Stephan Stilgenbauer, Aurélie Ernst, Andrey Korshunov, Pedro Castelo-Branco, Katharina I. Deeg, Stefan M. Pfister, Sebastian Bender, Peter Lichter, Marc Zapatka, Kendra K. Maass, David T.W. Jones, Agata Rode, Sebastian Brabetz, Karsten Rippe, Frauke Devens, Michael A. Tainsky, David Malkin, Cindy Zhang, Volker Hovestadt, Susanne Gröbner
Publikováno v:
International Journal of Cancer. 138:2905-2914
Chromothripsis is a recently discovered form of genomic instability, characterized by tens to hundreds of clustered DNA rearrangements resulting from a single dramatic event. Telomere dysfunction has been suggested to play a role in the initiation of
Publikováno v:
BMC Genetics
BMC Genetics, Vol 19, Iss 1, Pp 1-10 (2018)
BMC Genetics, Vol 19, Iss 1, Pp 1-10 (2018)
The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences that are protected by the shelterin protein complex. Cancer cells need to extend these telomere repeats for their unlimited proliferation, either by reactivating the rev
Autor:
Katharina I. Deeg, Stefan Wörz, Karl Rohr, Daniel Parisotto, Sarah Osterwald, Karsten Rippe, Holger Erfle, Inn Chung
Publikováno v:
Journal of Cell Science. 128:1887-1900
The alternative lengthening of telomeres (ALT) mechanism allows cancer cells to escape senescence and apoptosis in the absence of active telomerase. A characteristic feature of this pathway is the assembly of ALT-associated promyelocytic leukemia (PM