Zobrazeno 1 - 10
of 252
pro vyhledávání: '"I. David Goldman"'
Autor:
Srinivas Aluri, Rongbao Zhao, Charlotte Lubout, Susanna M.I. Goorden, Andras Fiser, I. David Goldman
Publikováno v:
Blood Advances, Vol 2, Iss 1, Pp 61-68 (2018)
Abstract: Hereditary folate malabsorption (HFM) is an autosomal recessive disorder characterized by impaired intestinal folate absorption and impaired folate transport across the choroid plexus due to loss of function of the proton-coupled folate tra
Externí odkaz:
https://doaj.org/article/fc34d8287359414cae7cd1d7eb067e43
Autor:
Tozammel Hoque, Susanne Aufreiter, Deborah L O'Connor, Richard H. Finnell, Constantine J. Georgiou, Reina Bendayan, I. David Goldman, Camille Alam
Publikováno v:
Proceedings of the National Academy of Sciences. 116:17531-17540
Folates are critical for central nervous system function. Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRα/Folr1), known to be regulated by ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1238e94d23cfbe5096c39859acfdac5
https://doi.org/10.1073/pnas.1907077116
https://doi.org/10.1073/pnas.1907077116
Publikováno v:
J Biol Chem
The Journal of biological chemistry, vol 294, iss 18
The Journal of biological chemistry, vol 294, iss 18
The proton-coupled folate transporter (PCFT) mediates intestinal absorption of folates and their transport from blood to cerebrospinal fluid across the choroid plexus. Substitutions at Asp-109 in the first intracellular loop between the first and sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607294eda5c98afb5c0e4647cfb75cf3
https://doi.org/10.1074/jbc.ra118.005533
https://doi.org/10.1074/jbc.ra118.005533
Autor:
Karim A. Sharif, I. David Goldman
Publikováno v:
BioTechniques, Vol 28, Iss 5, Pp 926-932 (2000)
Reported here is a new method that permits rapid (approximately 5 s) determinations of membrane transport phenomena in cells grown in monolayers at the base of 17-mm glass scintillation vials. The method is convenient, cost effective and requires no
Externí odkaz:
https://doaj.org/article/a9c12157ddb242b78d346c64940e7785
Autor:
He Qin Zhan, Mitra Najmi, Kai Lin, I. David Goldman, Rongbao Zhao, Srinivas Aluri, Andras Fiser
Publikováno v:
J Biol Chem
The proton-coupled folate transporter (PCFT, SLC46A1) is required for folate intestinal absorption and transport across the choroid plexus. Recent work has identified a F392V mutation causing hereditary folate malabsorption. However, the residue prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f4a04c2cd1b0b324a2c5499910f3ea
https://pubmed.ncbi.nlm.nih.gov/32893190
https://pubmed.ncbi.nlm.nih.gov/32893190
Publikováno v:
American Journal of Physiology-Cell Physiology. 314:C289-C296
The proton-coupled folate transporter (PCFT-SLC46A1) is required for folate transport across the apical membrane of the small intestine and across the choroid plexus. This study focuses on the structure/function of the 7th transmembrane domain (TMD),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40f18aec7bae433251d25891f93750b
https://doi.org/10.1152/ajpcell.00215.2017
https://doi.org/10.1152/ajpcell.00215.2017
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1859:2193-2202
The proton-coupled folate transporter (PCFT-SLC46A1) is required for intestinal folate absorption and folate transport across the choroid plexus. This report addresses the structure/function of the 8th transmembrane helix. Based upon biotinylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b878a80a68ec2be1e6499834f95f99
https://doi.org/10.1016/j.bbamem.2017.08.006
https://doi.org/10.1016/j.bbamem.2017.08.006
Publikováno v:
Molecular Pharmaceutics. 14:3848-3858
Folates are essential for brain development and function. Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa887029b3f73af4a9ced6ba0289245
https://doi.org/10.1021/acs.molpharmaceut.7b00572
https://doi.org/10.1021/acs.molpharmaceut.7b00572
Autor:
Susanna M. I. Goorden, Andras Fiser, Charlotte M A Lubout, I. David Goldman, Rongbao Zhao, Srinivas Aluri
Publikováno v:
Blood advances, 2(1), 61-68. American Society of Hematology
Hereditary folate malabsorption (HFM) is an autosomal recessive disorder characterized by impaired intestinal folate absorption and impaired folate transport across the choroid plexus due to loss of function of the proton-coupled folate transporter (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63efd00d84d4d1bd5a16cc41592335e9
https://pure.amc.nl/en/publications/hereditary-folate-malabsorption-due-to-a-mutation-in-the-external-gate-of-the-protoncoupled-folate-transporter-slc46a1(5a58fe2a-9dc8-4ac2-b3ba-9cbe69e99b96).html
https://pure.amc.nl/en/publications/hereditary-folate-malabsorption-due-to-a-mutation-in-the-external-gate-of-the-protoncoupled-folate-transporter-slc46a1(5a58fe2a-9dc8-4ac2-b3ba-9cbe69e99b96).html
Autor:
I. David Goldman, Ersin Selcuk Unal, Rongbao Zhao, Mitra Najmi, Michele Visentin, Andras Fiser
Publikováno v:
American Journal of Physiology-Cell Physiology. 308:C631-C641
The proton-coupled folate transporter (PCFT) mediates intestinal folate absorption and transport of folates across the choroid plexus. This study focuses on the role of Tyr residues in PCFT function. The substituted Cys-accessibility method identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200ee031745d2f43d68c6297c35718f6
https://doi.org/10.1152/ajpcell.00238.2014
https://doi.org/10.1152/ajpcell.00238.2014