First-line trifluridine/tipiracil + bevacizumab in patients with unresectable metastatic colorectal cancer: final survival analysis in the TASCO1 study

Autor: E. Van Cutsem, I. Danielewicz, M. P. Saunders, P. Pfeiffer, G. Argilés, C. Borg, R. Glynne-Jones, C. J. A. Punt, A. J. Van de Wouw, M. Fedyanin, D. Stroyakovskiy, H. Kroening, P. Garcia-Alfonso, H. Wasan, A. Falcone, R. Fougeray, A. Egorov, N. Amellal, V. Moiseyenko

Publikováno v: British journal of cancer, 126(11), 1548-1554. Nature Publishing Group
Scientia

Background Therapeutic options are limited in patients with unresectable metastatic colorectal cancer (mCRC) ineligible for intensive chemotherapy. The use of trifluridine/tipiracil plus bevacizumab (TT-B) in this setting was evaluated in the TASCO1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03af4faff5144bcdcf5517b7b9e24306
https://doi.org/10.1038/s41416-022-01737-2

Trifluridine/tipiracil plus bevacizumab in patients with untreated metastatic colorectal cancer ineligible for intensive therapy: the randomized TASCO1 study

Autor: C.J.A. Punt, Mark P Saunders, Daniil Stroyakovskiy, Nadia Amellal, Harpreet Wasan, A. Egorov, Hendrik Kroening, P. Aubel, Rob Glynne-Jones, I. Danielewicz, Christophe Borg, Guillem Argiles, V. Moiseenko, Alfredo Falcone, Akira Kanehisa, A.J. van de Wouw, E. Van Cutsem, Per Pfeiffer, P. García-Alfonso, Mikhail Fedyanin

Publikováno v: Annals of oncology, 31(9), 1160-1168. Oxford University Press
Scientia
Van Cutsem, E, Danielewicz, I, Saunders, M P, Pfeiffer, P, Argilés, G, Borg, C, Glynne-Jones, R, Punt, C J A, Van de Wouw, A J, Fedyanin, M, Stroyakovskiy, D, Kroening, H, Garcia-Alfonso, P, Wasan, H, Falcone, A, Kanehisa, A, Egorov, A, Aubel, P, Amellal, N & Moiseenko, V 2020, ' Trifluridine/tipiracil plus bevacizumab in patients with untreated metastatic colorectal cancer ineligible for intensive therapy : the randomized TASCO1 study ', Annals of Oncology, vol. 31, no. 9, pp. 1160-1168 . https://doi.org/10.1016/j.annonc.2020.05.024

Bevacizumab; Teràpia intensiva; Càncer colorectal metastàtic Bevacizumab; Terapia intensiva; Cáncer colorrectal metastásico Bevacizumab; Intensive therapy; Metastatic colorectal cancer Background We designed an open-label, noncomparative phase I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5428e52b5139a7b33481be36568a530
https://pubmed.ncbi.nlm.nih.gov/32544547

Lowering of the freezing temperature of water at the protein surface due to electric field

Autor: I. Danielewicz-Ferchmin, A. R. Ferchmin

Publikováno v: Journal of Molecular Liquids. 124:114-120

A new complementary mechanism of inhibiting water freezing at protein surface is proposed. It is based on the idea that the effect of the local electrostriction pressure Π related with the local electric field in the immediate vicinity of protein mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69e9f1da11202a4a3c124bfac675451f
https://doi.org/10.1016/j.molliq.2005.09.004

A critical point related to phase transitions in electrostricted H2O close to an electrode

Autor: I. Danielewicz-Ferchmin, A. R. Ferchmin

Publikováno v: Chemical Physics Letters. 398:186-189

It is found that phase transitions should occur between two phases of H2O with different degrees of orientational order of dipoles in a very high local field E ∼ 109 V m−1 at temperatures in the range 273–303 K. Critical point of H2O at T c E =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8744917dd4fad354254fd71b604040e
https://doi.org/10.1016/j.cplett.2004.09.051

Static permittivity of water revisited: ε in the electric field above 108V m−1and in the temperature range 273 ≤ T ≤ 373 K

Autor: I. Danielewicz-Ferchmin, A. R. Ferchmin

Publikováno v: Phys. Chem. Chem. Phys.. 6:1332-1339

Calculations are presented of the permittivity of water residing in conditions encountered in hydration shells. The present approach is applicable to water in high electric fields and in the whole range of temperature where it is liquid. Possible app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abdb891352aa5bb2b896c51fa955bc4e
https://doi.org/10.1039/b314337f