Zobrazeno 1 - 10
of 149
pro vyhledávání: '"I. Chaban"'
Publikováno v:
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, Vol 14, Iss 3, Pp 320-327 (2021)
The problem of finding effective low-toxic anticancer agents is one of the most important in modern medicine and pharmacy. Despite a large selection of anticancer drugs and a variety of mechanisms of their action, the effectiveness of existing drugs
Externí odkaz:
https://doaj.org/article/2546cc6c90554ff1aca329df70fe4731
Publikováno v:
Фармацевтичний журнал, Vol 5, Pp 37-49 (2021)
One of the promising methods of creating antitumor drugs is the screening of potential antitumor agents among synthesized compounds. Nitrogen-based heterocycle analogues are an extremely important class of organic substances that are widely used in m
Externí odkaz:
https://doaj.org/article/f18de5a227b44a108103d684ac4cf43d
Publikováno v:
Фармацевтичний журнал, Vol 1, Pp 17-25 (2021)
As a result of metabolic transformations of substances in the human body in the reactions of lipid peroxidation, reactive oxygen species are formed. Normally, the regulation of the production of activated oxygen metabolites and free radicals in human
Externí odkaz:
https://doaj.org/article/1cf91c6d8d734d81afce7f72454489e5
Autor:
Taras I. Chaban, Julia E. Matiychuk, Olga Ya. Shyyka, Ihor G. Chaban, Volodymyr V. Ogurtsov, Ihor A. Nektegayev, Vasyl S. Matiychuk
Publikováno v:
Acta Chimica Slovenica, Vol 67, Iss 4, Pp 1035-1043 (2020)
The synthesis, anti-inflammatory and antioxidant properties of novel 5-hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one derivatives were discussed. Fused thiazolo[4,5-b]pyridin-2-ones were synthesized and modified at the N3, C5 and C6 positions of th
Externí odkaz:
https://doaj.org/article/b71c522e9d1840ed9efab919c4e2b4f0
Publikováno v:
Indonesian Journal of Pharmacy, Pp 150-160 (2020)
New N-(5-R-benzyl-1,3-thiazol-2-yl)-2-morpholin-4-yl-2-oxoacetamides have been prepared in good yields via the reaction of N-(5-R-benzyl-1,3-thiazol-2-yl)-2-chloroacetamides with sulfur and morfoline. These compounds react with ethendiamine to form a
Externí odkaz:
https://doaj.org/article/cc774255fd6f40ce8aa038b406206d9d
Publikováno v:
The Ukrainian Biochemical Journal, Vol 92, Iss 2, Pp 132-139 (2020)
In an effort to develop novel anti-inflammatory agents, a series of thiazolo[4,5-b]pyridines were synthesized and modified at the N3 position. The structures of the obtained compounds were confirmed by 1H NMR spectroscopy and elemental analysis. The
Externí odkaz:
https://doaj.org/article/242d7b3868fa42f2835fa3987cd0e259
Synthesis of some new thiazolo[4,5-b]pyridin-2-ones and research of their anti-inflammatory activity
Autor:
T. I. Chaban
Publikováno v:
Фармацевтичний журнал, Vol 4, Iss 4, Pp 52-60 (2019)
In modern theoretical and clinical medicine inflammation problem remains one of the main.Deregulation of inflammatory processes leads to specific pathologies.There is a significant amount of drugs used to treat inflammation. But all of them have vary
Externí odkaz:
https://doaj.org/article/439df6ec1a044367b63ff1b67462145f
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 17, Iss 3, Pp 15-20 (2019)
Aim. To expand the synthetic potential of thiazolo[4,5-b]pyridines, study the reactivity and perform the pharmacological screening of the antioxidant activity of the novel compounds synthesized. Results and discussion. A series of novel 3-aryl-5-hyd
Externí odkaz:
https://doaj.org/article/85dbb918874d422db507499df66b52e4
Publikováno v:
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, Vol 12, Iss 2, Pp 129-134 (2019)
Condensed bicyclic systems with thiazolidine core being annulated to pyridine one occupy prominent place in medicinal chemistry because of their broad spectrum of pharmacological activities. So, the synthesis of new N3 substitutes thiazolo[4,5-b]pyri
Externí odkaz:
https://doaj.org/article/38c595cee4e84b48abcfbeb18b70aa47
Autor:
Taras I. Chaban, Volodymyr V. Ogurtsov, Vasyl S. Matiychuk, Ihor G. Chaban, Inna L. Demchuk, Ihor A. Nektegayev
Publikováno v:
Acta Chimica Slovenica, Vol 66, Iss 1, Pp 103-111 (2019)
5-Hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one was obtained by the reaction of 4-iminothiazolidin-2-one with acetoacetic ester. Further structural modifications include the introduction of diversity at the C5 and C6 positions. The anti-inflammato
Externí odkaz:
https://doaj.org/article/0e1d5494b20e4716a19983c7f8924ede