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Vascular units as advanced living materials for bottom-up engineering of perfusable 3D microvascular networks

Autor: I.D. Orge, H. Nogueira Pinto, M.A. Silva, S.J. Bidarra, S.A. Ferreira, I. Calejo, R. Masereeuw, S.M. Mihăilă, C.C. Barrias

Publikováno v: Bioactive Materials, Vol 38, Iss , Pp 499-511 (2024)

The timely establishment of functional neo-vasculature is pivotal for successful tissue development and regeneration, remaining a central challenge in tissue engineering. In this study, we present a novel (micro)vascularization strategy that explores

Externí odkaz: https://doaj.org/article/7fc399d7f65d4461a0dd36fa05347132

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Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure

Publikováno v: Circulation. 147:1221-1236

Background: Increasing SERCA2 (sarco[endo]-plasmic reticulum Ca 2+ ATPase 2) activity is suggested to be beneficial in chronic heart failure, but no selective SERCA2-activating drugs are available. PDE3A (phosphodiesterase 3A) is proposed to be prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e63a68ac09949d6f49d8b7e1ad749c11
https://doi.org/10.1161/circulationaha.121.054168

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Differences in the expression pattern of HCN isoforms among mammalian tissues: sources and implications

Autor: Robert Zorec, Virgília S. Silva, Paula Gonçalves, Ana I. Calejo, Patrícia M. Pereira, Marisa Reverendo, Manuel A. S. Santos

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play a critical role in a broad range of cell types, but the expression of the various HCN isoforms is still poorly understood. In the present study we have compared the expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54df973b874882a126e8807cbcdc55e4
https://doi.org/10.1007/s11033-013-2862-2

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Vesicle size determines unitary exocytic properties and their sensitivity to sphingosine

Autor: Robert Zorec, Ajda Flašker, Ana I. Calejo, Marko Kreft, Jernej Jorgačevski

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Neuroendocrine cells contain small and large vesicles, but the functional significance of vesicle diameter is unclear. We studied unitary exocytic events of prolactin-containing vesicles in lactotrophs by monitoring discrete steps in membrane capacit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d7882f641376442a8000c2942c9f12
https://doi.org/10.1016/j.mce.2013.06.012

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cAMP-Mediated Stabilization of Fusion Pores in Cultured Rat Pituitary Lactotrophs

Autor: Ana I. Calejo, Robert Zorec, Marek Kucka, Paula Gonçalves, Stanko S. Stojilkovic, Jernej Jorgačevski, Marko Kreft

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Regulated exocytosis mediates the release of hormones and transmitters. The last step of this process is represented by the merger between the vesicle and the plasma membranes, and the formation of a fusion pore. Once formed, the initially stable and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144c75ff8f4ddd2496d4bfc4c0e647e6
https://doi.org/10.1523/jneurosci.5351-12.2013

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Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels and cAMP-Dependent Modulation of Exocytosis in Cultured Rat Lactotrophs

Autor: Alenka Guček, Robert Zorec, Manuel A. S. Santos, Boštjan Rituper, Patrícia M. Pereira, Paula Gonçalves, Jernej Jorgačevski, Ana I. Calejo, Maja Potokar, Nina Vardjan, Marko Kreft

Hormone and neurotransmitter release from vesicles is mediated by regulated exocytosis, where an aqueous channel-like structure, termed a fusion pore, is formed. It was recently shown that second messenger cAMP modulates the fusion pore, but the deta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac817179e0f7d3501315665b2bc73b91
https://europepmc.org/articles/PMC6608442/

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