Výsledky vyhledávání - "I. C. M. MacLennan"

A subset of CD4+ memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex

Autor: I. C. M. MacLennan, Mahmood Khan, M. Casamayor-Palleja

Publikováno v: The Journal of Experimental Medicine

Signaling through surface CD40 is essential for selecting B cells that have mutated their immunoglobulin variable region genes in germinal centers and is an important signal in the early stages of antibody responses to T cell-dependent antigens. It i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b4d9f1302c815943e8093f04e91c21
https://doi.org/10.1084/jem.181.4.1293

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A phenotypic study of B lymphocyte subpopulations in human bone marrow

Autor: G. D. Johnson, I. C. M. Maclennan, M. R. Chapple

Publikováno v: Clinical and Experimental Immunology. 81:166-172

SUMMARY The regulatory mechanisms that monitor the size of the peripheral B cell pool and determine cell death or survival are poorly understood. In rodents B lymphopoiesis is maintained at a high rate throughout adult life, and under resting conditi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1ace426fbac6b3f36c233548cbe1c8
https://doi.org/10.1111/j.1365-2249.1990.tb05309.x

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Origin and properties of soluble CD21 (CR2) in human blood

Autor: G D Johnson, N.R. Ling, Debbie L. Hardie, I. C. M. MacLennan

Publikováno v: Clinical and experimental immunology. 113(3)

SUMMARYBy analysis with a panel of CD21 MoAbs it is shown that a large part of the soluble CD21 in human blood plasma is of the long isoform (CD21L), as judged by comparison with antigen produced by mouse L cells transfected with CD21L-cDNA and react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1ec6291e0d4816006b29a1811a69e9
https://pubmed.ncbi.nlm.nih.gov/9737663

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In Which Cells Does Neoplastic Transformation Occur in Myelomatosis?

Autor: I. C. M. MacLennan

Publikováno v: Current Topics in Microbiology and Immunology ISBN: 9783642776359

Myelomatosis is strictly a neoplasm of plasma cells in bone marrow. It does not involve other sites of antibody production; thus, even when the monoclonal protein produced by the neoplastic clone is IgA1 or IgA2 the neoplastic cells are not found in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93e6f50e1cf2818aa3fc8616834f03a6
https://doi.org/10.1007/978-3-642-77633-5_25

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The Origin of Bone Marrow Plasma Cells

Autor: I. C. M. MacLennan, E. Y. T. Chan

Publikováno v: Epidemiology and Biology of Multiple Myeloma ISBN: 9783642766572

Myelomatosis is a neoplasm of bone marrow plasma cells, which characteristically does not involve other sites of antibody production such as the gut [Leonard et al 1979]. It is also a feature of the disease that the malignant plasma cells are usually

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7128eff3ec9c262168a7a683c4c39c7a
https://doi.org/10.1007/978-3-642-76655-8_21

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Human major histocompatibility complex class II invariant chain is expressed on the cell surface

Autor: P. Möller, N. R. Ling, G. Moldenhauer, Norbert Koch, P. Van Endert, I. C. M. Maclennan, C. J. Wraight, J. Lipp

Publikováno v: Europe PubMed Central
Scopus-Elsevier

Class II major histocompatibility complex antigens are intracellularly associated with a nonpolymorphic polypeptide referred to as the invariant chain. Before the class II heterodimer appears on the cell surface, the invariant chain dissociates but i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b04590d780ceaed788e572bab65c08
https://pubmed.ncbi.nlm.nih.gov/1690714

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The Evolution of B-Cell Clones

Autor: Peter J. L. Lane, I. C. M. MacLennan, Susan Oldfield, Yong-Jun Liu, Jun Zhang

Publikováno v: Immunological Memory ISBN: 9783642752469

Large numbers of B cells are produced throughout life as the result of both primary B lymphopoiesis (Opstelten and Osmond 1983) and antigen-driven B- cell proliferation (Fliedner et al. 1964). It is a feature of the system that a high proportion of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::478a2aa640d53af4218bee12e7033278
https://doi.org/10.1007/978-3-642-75244-5_3

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Prognostic factors in non-Hodgkin's lymphoma: the importance of symptomatic stage as an adjunct to the Kiel histopathological classification

Autor: R. C. F. Leonard, I. C. M. MacLennan, Jack Cuzick, C V McCormick, R. I. Vanhegan, P H Mackie

Publikováno v: British Journal of Cancer

A prospective study of prognostic factors for patients with non-Hodgkin's lymphoma was carried out based on the Kiel histopathological classification. Other presentation features assessed for prognostic value included clinical features, haematologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02066f98370bd698a083b386cc4c0a1
http://europepmc.org/articles/PMC2011241

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