Výsledky vyhledávání - "I. C. A. F. Robinson"

HESX1: a novel gene implicated in a familial form of septo-optic dysplasia

Autor: Paul Q. Thomas, Rsp Beddington, Peter C. Hindmarsh, Joshua M. Brickman, Jkh Wales, I. C. A. F. Robinson, Mehul T. Dattani, Juan Pedro Martinez-Barbera, Rajeev Gupta

Publikováno v: Europe PubMed Central

The homeobox gene Hesx1, which encodes a pituitary transcription factor, is first expressed at gastrulation in the mouse embryo. Hesx1 expression begins in prospective forebrain tissue but later becomes restricted to Rathke's pouch, the primordium of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609525f50101a803204536c3c913529c
https://doi.org/10.1111/j.1651-2227.1999.tb14403.x

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Hypothalamic targets for growth hormone secretagogues

Autor: I. C. A. F. Robinson

Publikováno v: Acta Paediatrica. 86:88-91

Various novel growth hormone (GH) secretagogues have been developed. GH secretagogues release GH directly from the pituitary via a pathway distinct from that involving GH-releasing hormone (GHRH). However, they also act centrally to activate hypothal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e44b7490799278702bfbdb809b99ec
https://doi.org/10.1111/j.1651-2227.1997.tb18382.x

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Growth Hormone Secretagogues Stimulate the Hypothalamic-Pituitary-Adrenal Axis and Are Diabetogenic in the Zucker Diabetic Fatty Rat1

Autor: Keith M. Fairhall, I. C. A. F. Robinson, G. B. Thomas, Y. H. Ma, Wesley Won, Ross G. Clark, Deborah L. Mortensen, E.E. Tomlinson

Publikováno v: Endocrinology. 138:4316-4323

Besides stimulating GH release, some GH secretagogues also release ACTH and adrenal steroids. Several novel classes of potent GH secretagogues have recently been described, and we have now tested their ability to release corticosterone in conscious n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1def31222d7c184e45bd32d014bd2327
https://doi.org/10.1210/endo.138.10.5424

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The human growth hormone (hGH) antagonist G120RhGH does not antagonize GH in the rat, but has paradoxical agonist activity, probably via the prolactin receptor

Autor: I. C. A. F. Robinson, W. Y. Chen, J. J. Kopchick, Timothy N. C. Wells, R. G. Clark, P. Tollet, D. F. Carmignac, Agneta Mode

Publikováno v: Scopus-Elsevier

Human GH (hGH) acts by dimerizing two hGH receptors that bind to different sites in hGH. G120RhGH, an analog mutated in the second binding site to prevent receptor dimerization, acts as an antagonist in vitro. We have now tested the activity of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4598aa8755abbb32313a603031984e
https://doi.org/10.1210/endo.137.2.8593788

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Sexual dimorphism of hepatic 11β-hydroxysteroid dehydrogenase in the rat: the role of growth hormone patterns

Autor: I C A F Robinson, Karen E. Chapman, C. R. W. Edwards, S. C. Low, Jonathan R. Seckl, T Wells

Publikováno v: Scopus-Elsevier

11 β-Hydroxysteroid dehydrogenase (11β-HSD) catalyses the reversible metabolism of corticosterone to inert 11-dehydrocorticosterone. At least two isoforms exist. 11β-HSD-1, the first to be characterised and the only isoform for which a cDNA has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030519371daf7b90a656586e3f93f951
https://doi.org/10.1677/joe.0.1430541

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The effects of a growth hormone-releasing Peptide and growth hormone-releasing factor in conscious and anaesthetized rats

Autor: I. C. A. F. Robinson, R. G. Clark, L. M. S. Carlsson, J. Trojnar

Publikováno v: Journal of neuroendocrinology. 1(4)

The growth hormone (GH) releasing ability of GH-releasing factor (GRF) and a GH-releasing hexapeptide, CHRP, have been studied in anaesthetized and conscious male and female rats. The GH responses to GHRP in anaesthetized rats were inconsistent, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388af88d6364d5227425c6453d1b4a59
https://pubmed.ncbi.nlm.nih.gov/19210437

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Release of Oxytocin into Blood and into Cerebrospinal Fluid Induced by Naloxone in Anaesthetized Morphine-Dependent Rats: The Role of the Paraventricular Nucleus

Autor: I. C. A. F. Robinson, John A. Russell, Ferenc A. Antoni, J. E. Coombes

Publikováno v: Journal of Neuroendocrinology. 3:551-561

Opioid actions on oxytocin secretion into blood and cerebrospinal fluid (CSF) were investigated in urethane-anaesthetized female rats after intracerebroventricular (icv) infusion of morphine sulphate or vehicle for 5 days. Serial femoral arterial blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87130bd3c6d38e3713510fa13ff9d0dd
https://doi.org/10.1111/j.1365-2826.1991.tb00316.x

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