Zobrazeno 1 - 10
of 350
pro vyhledávání: '"I. Bednar"'
Publikováno v:
Journal of Neural Transmission. 112:255-268
Transgenic mice over-expressing human acetylcholinesterase (hAChE-Tg) display memory impairments, cholinergic deficits and reduced dendritic branching. In this study, we found a reduced number of N-Methyl-D-Aspartate (NMDA) binding sites and reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca8900486c5cf5f8bebabb2a6f66db8
https://doi.org/10.1007/s00702-004-0183-2
https://doi.org/10.1007/s00702-004-0183-2
Publikováno v:
Neuropharmacology. 47:558-571
Overexpression of acetylcholinesterase (AChE) in mice causes cholinergic deficits with memory impairment. In this study, AChE overexpressing (hAChE-Tg) and control (FVB/N) mice were treated with the AChE inhibitor (AChEI) galantamine (4 mg/kg/day) fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff61c3385d94d5115358530e2925bf00
https://doi.org/10.1016/j.neuropharm.2004.06.009
https://doi.org/10.1016/j.neuropharm.2004.06.009
Publikováno v:
International Journal of Developmental Neuroscience. 22:545-549
In this study, we investigated regulatory mechanisms and plasticity of the nicotinic acetylcholine receptors (nAChRs) in the brain and adrenal glands of two transgenic mice models over-expressing human beta-amyloid precursor protein (APP(SWE)Tg) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c63d5f2e13e0f3c299279687262f99
https://doi.org/10.1016/j.ijdevneu.2004.07.005
https://doi.org/10.1016/j.ijdevneu.2004.07.005
Autor:
Jennifer A. Court, Elaine K. Perry, Agneta Nordberg, Amelia Marutle, Alan J. Thomas, I. Bednar, M. Lee, Ewa Hellström-Lindahl, Marie Svedberg, Jessica Keverne
Publikováno v:
European Journal of Neuroscience. 19:2703-2710
Ten days treatment with nicotine reduced insoluble amyloid A beta 1-40 and Alpha beta 1-42 peptides by 80% in the cortex of 9-month-old APPsw mice, which is more than that observed in 14.5-month-old mice following nicotine treatment for 5.5 months. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c36545d1a52023b370fa5a31811788
https://doi.org/10.1111/j.0953-816x.2004.03377.x
https://doi.org/10.1111/j.0953-816x.2004.03377.x
Publikováno v:
Neuroscience Letters. 340:148-152
Subtypes of nicotinic (alpha4 and alpha7) as well as muscarinic (M1 and M2) receptor binding sites were quantified in the brain of transgenic mice overexpressing human acetylcholinesterase (AChE) at different ages using selective radioligands. A sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13d3b3868dfe50c815ae6784d6636f5
https://doi.org/10.1016/s0304-3940(03)00092-2
https://doi.org/10.1016/s0304-3940(03)00092-2
Autor:
M. Lee, Jennifer A. Court, Elaine K. Perry, Mary Johnson, Ros Hall, Agneta Nordberg, I. Bednar, Malahat Mousavi, Ewa Hellström-Lindahl
Publikováno v:
Journal of Neurochemistry. 81:655-658
Alzheimer's disease neuropathology is characterised by beta-amyloid plaques and neurofibrillary tangles. Inhibition of beta-amyloid accumulation may be essential for effective therapy in Alzheimer's disease. In this study we have treated transgenic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d1faec805afb29ccfbbf515e611d7f4
https://doi.org/10.1046/j.1471-4159.2002.00874.x
https://doi.org/10.1046/j.1471-4159.2002.00874.x
Publikováno v:
International Journal of Developmental Neuroscience. 16:661-668
The basal forebrain cholinergic neurons are implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). The nicotinic acetylcholine receptors (nAChRs) have been found to be significantly afflicted in AD. To study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5cf99e98a57888b08085c20bfc1151
https://doi.org/10.1016/s0736-5748(98)00076-8
https://doi.org/10.1016/s0736-5748(98)00076-8
Publikováno v:
Europe PubMed Central
A dopamine D1 (SKF-38393, 1 mg)- or D2 (LY-171555, 0.1 mg)-receptor agonist inhibited intake of an intraorally infused solution of sucrose by male rats, a test of consummatory ingestive behavior. Treatment with a D1 (SCH-39166, 0.1 mg) or D2 (raclopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df72976241c576d681859cb3f39b6e5a
https://doi.org/10.1152/ajpregu.1995.269.4.r896
https://doi.org/10.1152/ajpregu.1995.269.4.r896
Publikováno v:
Pharmacology Biochemistry and Behavior. 51:9-12
Ingestive behavior was activated in male rats by intraoral infusion of a 1-M solution of sucrose. Injection of cholecystokinin octapeptide (CCK-8; 1.6 or 5.0 μg) inhibited ingestion of the sucrose solution and increased the concentration of 5-hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4cb6b970cc709d9c6eb9758d4e7b65
https://doi.org/10.1016/0091-3057(94)00400-d
https://doi.org/10.1016/0091-3057(94)00400-d
Publikováno v:
Journal of Neuroendocrinology. 6:403-408
Male rats treated with reserpine were motionless and ingested only a few of ten consecutive intraoral injections of a 1 M solution of sucrose. While injection of apomorphine, a dopamine agonist, stimulated locomotion and stereotyped sniffing in reser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf8359559586a3b2dee1eb7b6ae9db4
https://doi.org/10.1111/j.1365-2826.1994.tb00600.x
https://doi.org/10.1111/j.1365-2826.1994.tb00600.x