Zobrazeno 1 - 10
of 59
pro vyhledávání: '"I. Basnak"'
Autor:
Richard T. Walker, Erik De Clercq, I. Basnak, Robert Snoeck, Annalisa Verri, Richard J. Duncombe, Federico Focher, Silvio Spadari, Graciela Andrei, Jan Balzarini, Paul L. Coe
Publikováno v:
Biochemical Journal. 351:319-326
The antiviral activity of several nucleoside analogues is often limited by their rapid degradation by pyrimidine nucleoside phosphorylases. In an attempt to avoid this degradation, several modified nucleosides have been synthesized. A series of 4´-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8231af459863ce034dbd0760440d6730
https://doi.org/10.1042/bj3510319
https://doi.org/10.1042/bj3510319
Autor:
Li Wei-Zhong, I. Basnak, Yu Ming, Wang Jin-Ling, Richard T. Walker, T. A. Hamor, Miao Fang-Ming, Sun Ming
Publikováno v:
Acta Physico-Chimica Sinica. 15:834-837
substituted 6 aza 2' deoxyuridines are inhibitors of herps simplex virius type 1 thymidine kinase (HSV 1 TK). In this paper, the semiempirical self consistent field PM3 calculations have been undertaken for two typical HSV 1 TK inhibitors: compound (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8f74d73cc9feed9ca7abe4444aec1a0
https://doi.org/10.3866/pku.whxb19990912
https://doi.org/10.3866/pku.whxb19990912
Publikováno v:
Scopus-Elsevier
We report that a thymidine kinase (TK) activity is present in Trichomonas vaginalis and can be separated from the deoxyribonucleoside phosphotransferase. T. vaginalis TK, purified 11200-fold to apparent homogeneity, has a molecular mass of 31500 Da.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65c5bd17b8c35d0fdcd13030d1cd4d8
https://doi.org/10.1042/bj3340015
https://doi.org/10.1042/bj3340015
Publikováno v:
Tetrahedron Letters. 38:4869-4872
( E )-5-(2-Carbomethoxyvinyl)-2,4-dimethoxypyrimidine ( 2 ) was prepared in high yield (90%) at room temperature from 5-iodo-2,4-dimethoxypyrimidine ( 1a ) via the heterogenous Heck-reaction with methyl acrylate in aqueous solution containing n-Bu 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2a142cf0bf7252a606e05f09d52fa04
https://doi.org/10.1016/s0040-4039(97)01015-0
https://doi.org/10.1016/s0040-4039(97)01015-0
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :121-126
A new type of 2-oxo-1,2-dihydrocyclobuta[d]pyrimidin-1-yl-2′- deoxynucleoside 2a is obtained in 52% yield upon irradiation of aqueous solutions of 5-tert-butyl-2′-deoxyuridine 1a with short wavelength (254 nm) UV light. The identity and structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa3a117863b36b885b4ca27b078be122
https://doi.org/10.1039/a604244i
https://doi.org/10.1039/a604244i
Publikováno v:
Tetrahedron. 52:10159-10168
Photoirradiation of 5- t -butyl-1-methyluracil at 254 nm results in the production of a 1,2-dihydro-1-methyl-pyrimidin-2-one in high yield. The structure was confirmed by X-ray analysis. When subjected to alkaline conditions, a bathochromic shift in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdeef1272101a622a66b2374502a9037
https://doi.org/10.1016/0040-4020(96)00538-8
https://doi.org/10.1016/0040-4020(96)00538-8
Publikováno v:
Nucleosides and Nucleotides. 15:1275-1285
5-Cyclohexyl-2′-deoxyuridine (I) is an example of a 5-substituted pyrimidine 2′-deoxynucleoside which exhibits no antiviral activity and which is not a substrate for either cellular or viral (herpes) kinases. Despite the fact that a cursory inspe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95dc1a75fd06b0fa060e18cfee216a97
https://doi.org/10.1080/07328319608002429
https://doi.org/10.1080/07328319608002429
Publikováno v:
Collection of Czechoslovak Chemical Communications. 61:5-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49847f32ec277feb4e38432eb95c3a9d
https://doi.org/10.1135/cccc1996s005
https://doi.org/10.1135/cccc1996s005
Publikováno v:
Nucleosides and Nucleotides. 15:121-134
The silylated pyrimidine bases IIa-d were condensed with the benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-d-erythro-pentofuranoside III in acetonitrile under activation by N-iodosuccinimide, giving ca 1.5: 1/α: β anomeric mixtures of the blocked nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c0417a9523a23189653dc0246dad67e
https://doi.org/10.1080/07328319608002375
https://doi.org/10.1080/07328319608002375
Publikováno v:
Nucleosides and Nucleotides. 13:177-196
5-Alkyl(cycloalkyl)-2′-deoxyuridines VIa-VIf were synthesised in high yields by condensation of the corresponding silylated bases with 2-deoxy-3,5-di O-p-toluoyl-D-erthro-pentosyl chloride in chloroform and subsequent deblocking with sodium methoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57a479729658a756518a41185e986d5f
https://doi.org/10.1080/15257779408013234
https://doi.org/10.1080/15257779408013234