Zobrazeno 1 - 10
of 29
pro vyhledávání: '"I. Aigha"'
Autor:
Yasmin Abu Aqel, Aldana Alnesf, Idil I. Aigha, Zeyaul Islam, Prasanna R. Kolatkar, Adrian Teo, Essam M. Abdelalim
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-27 (2024)
Abstract Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver. Mutations in the GCK gene have been associated with vari
Externí odkaz:
https://doaj.org/article/94abed84c9244b8cb8991f8a4ba46a8d
Autor:
Idil I. Aigha, Essam M. Abdelalim
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2020)
Abstract Understanding the biology underlying the mechanisms and pathways regulating pancreatic β cell development is necessary to understand the pathology of diabetes mellitus (DM), which is characterized by the progressive reduction in insulin-pro
Externí odkaz:
https://doaj.org/article/259756ada587402c94f8c97958e337c3
Autor:
Idil I. Aigha, Essam M. Abdelalim
Publikováno v:
Stem Cell Reviews and Reports. 19:942-952
The multipotent pancreatic progenitor cells (MPCs) co-expressing the transcription factors, PDX1 and NKX6.1, are the source of functional pancreatic β-cells. The aim of this study was to examine the effect of p53 inhibition in MPCs on the generation
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-11 (2018)
Abstract Background The expression of a specific combination of transcription factors (TFs) in the multipotent progenitor cells (MPCs) is critical for determining pancreatic cell fate. NKX6.1 expression in PDX1+ MPCs is required for functional β cel
Externí odkaz:
https://doaj.org/article/de8ea88ea2924002847db37cfd23546f
Autor:
Lotfi Chouchane, Francesco M. Marincola, Ena Wang, Edith Mathiowitz, Stacia Furtado, Salah Gehani, Issam Al-Bozom, Joel Malek, Idil I. Aigha, Dhanya Kizhakayil, Shahinaz Bedri, Konduru S. Sastry, Maria L. Ascierto, Eman K. Al-Azwani, Sasha Bakhru, Shoba P. DSouza, Jingxuan Shan
PDF file - 655K, Supplementary Figure 1. TNRC9 promoted cell proliferation in MDA-MB-231 breast cancer cells. Supplementary Figure 2. shRNA-mediated knockdown of TNRC9. Supplementary Figure 3. H&E staining of tumors (10�Magnification) from xenograf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bf9a73d9f83aac4f053411ba15b6d9
https://doi.org/10.1158/0008-5472.22399677
https://doi.org/10.1158/0008-5472.22399677
Autor:
Essam M. Abdelalim, Idil I. Aigha
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2020)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Understanding the biology underlying the mechanisms and pathways regulating pancreatic β cell development is necessary to understand the pathology of diabetes mellitus (DM), which is characterized by the progressive reduction in insulin-producing β
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-11 (2018)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background The expression of a specific combination of transcription factors (TFs) in the multipotent progenitor cells (MPCs) is critical for determining pancreatic cell fate. NKX6.1 expression in PDX1+ MPCs is required for functional β cell generat
Publikováno v:
Cell Metabolism. 31:327-338.e6
Summary The beta (β)-cell mass formed during embryogenesis is amplified by cell replication during fetal and early postnatal development. Thereafter, β cells become functionally mature, and their mass is maintained by a low rate of replication. For
Publikováno v:
Qatar Foundation Annual Research Conference Proceedings Volume 2018 Issue 2.
Diabetes is a metabolic disease caused by the loss or impaired function of insulin-producing pancreatic β-cells. Different therapeutic strategies aim to restore the endogenous production of insulin rather than the cornerstone insulin injections trea
Publikováno v:
Qatar Foundation Annual Research Conference Proceedings Volume 2018 Issue 2.
Diabetes is a metabolic disease caused by the loss or impaired function of insulin-producing pancreatic β-cells. Different therapeutic strategies aim to restore the endogenous production of insulin rather than the cornerstone insulin injections trea