Zobrazeno 1 - 10
of 19
pro vyhledávání: '"I. A. Miroshkina"'
Autor:
A. V. Volkova, A. D. Zakharov, A. V. Sorokina, V. V. Zabrodina, I. A. Miroshkina, K. S. Kachalov, I. V. Alekseev, S. V. Alekseeva
Publikováno v:
Pharmacokinetics and Pharmacodynamics. :51-57
Relevance. Assay of acute toxicity is a mandatory step in a preclinical safety study of medicines and pharmaceutical substances. The purpose of this study was to determine the parameters of acute toxicity of the substance GIZH-298. Methods. GIZH-298
Publikováno v:
Pharmacokinetics and Pharmacodynamics. :41-44
Purpose of the study. Comparative evaluation of echocardiographic and morphometric dimensions of the rat heart left ventricle. Materials and methods. The study included 10 outbred male rats weighing 160–180 g. The size of the heart left ventricle w
Autor:
A. V. Sorokina, A. K. Zhanataev, Z. V. Chayka, I. A. Miroshkina, A. A. Lisitsyn, A. D. Durnev
Publikováno v:
Pharmacokinetics and Pharmacodynamics. :43-49
Relevance. Diabetes mellitus is a widespread, socially significant disease. In this regard, it is important to obtain an experimental model that precedes subsequent experiments on pharmacological screening and/or study of the mechanism of action of a
Autor:
I. A. Miroshkina, A. V. Sorokina, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, S. A. Kryzhanovskiy, A. D. Durnev
Publikováno v:
Pharmacokinetics and Pharmacodynamics. :29-35
The purpose of the study. Investigation of the effect of the fabomotizol dihydrochloride systematic therapy on the morphological picture of the heart left ventricle (LV) in rats in the subacute period of myocardial infarction. Materials and methods.
Publikováno v:
Human Physiology. 47:478-487
Part II of the review considers the literature data that pronounced cardioprotective activity is possessed by sigma-1 receptors (σ1Rs) and is associated with both membranotropic and chaperone activities. Activated σ1Rs exert a distinct antiarrhythm
Autor:
I. A. Miroshkina, I. V. Alekseev, A. D. Zaharov, A. V. Sorokina, A. S. Lapizkaya, K. S. Kachalov, S. V. Alekseeva
Publikováno v:
Pharmacokinetics and Pharmacodynamics. :52-60
Presents results of a study of subchronic toxicity of homeopathic drug Dantinorm Baby in finished dosage form. The drug in the form of a ready solution was administered daily orally for one month to outbred rats Infanta and chinchilla rabbits at a do
Autor:
I. A. Miroshkina, S. A. Kryzhanovskii
Publikováno v:
Human Physiology. 47:219-231
The first part of the review examines in detail the structure of sigma-1 (σ1) receptors and the specifics of their intracellular localization and translocation. Literature data indicates that the σ1 receptors that are part of the so-called lipid dr
Autor:
S. A. Kryzhanovskii, V. V. Barchukov, Andrey D. Durnev, I A Miroshkina, I. B. Tsorin, L. M. Kozhevnikova, V. N. Stolyaruk, M. B. Vititnova, E. O. Ionova, A. V. Sorokina
Publikováno v:
Bulletin of Experimental Biology and Medicine. 167:706-710
We created a translational model of chronic heart failure in rats that developed in 3 months after reproducing experimental anterior transmural myocardial infarction. The model simulated the basic clinicodiagnostic criteria of this disease: impaired
Autor:
Ya. Ya. Gavrilov, K. A. Tupikin, G. G. Karmazanovsky, A. B. Varava, I. V. Miroshkina, V. А. Vishnevsky, O. I. Andreytseva
Publikováno v:
Annaly khirurgicheskoy gepatologii = Annals of HPB surgery. 21:103-108
Publikováno v:
Cell and Tissue Biology. 11:286-292
The phenomenon of atypical DNA comets observed in experiments using DNA-comet assay is described and illustrated. The current hypotheses explaining the nature of atypical DNA comets and our own take on the issue are considered. The practical importan