Effectiveness of full Pulpotomy compared with Root canal treatment in managing teeth with signs and symptOms indicative of irreversible pulpitis: a protocol for prospectiVE meta-analysis of individual participant data of linked randomised clinical trials (PROVE)

Autor: I. A. El Karim, H. F. Duncan, A. F. Fouad, N. A. Taha, V. Yu, S. Saber, V. Ballal, P. Chompu-inwai, H. M. A. Ahmed, B. P. F. A. Gomes, S. Abushouk, S. Cushley, C. O’Neill, M. Clarke

Publikováno v: Trials, Vol 24, Iss 1, Pp 1-10 (2023)

Abstract Background Full pulpotomy has been proposed as an alternative to root canal treatment in teeth with signs and symptoms indicative of irreversible pulpitis (IRP), but the evidence is limited, relying on underpowered studies with a high risk o

Externí odkaz: https://doaj.org/article/ae983a55ad5544f99335925d328d4d26

Efficacy of direct pulp capping for management of cariously exposed pulps in permanent teeth: a systematic review and meta‐analysis

Autor: I A El-Karim, P Chua, Mike Clarke, Henry F. Duncan, Mark Lappin, S. Cushley, A D Elamin

Publikováno v: Cushley, S, Duncan, H F, Lappin, M J, Chua, P, Elamin, A D, Clarke, M & El-Karim, I A 2020, ' Efficacy of direct pulp capping for management of cariously exposed pulps in permanent teeth: A systematic review and meta-analysis ', International Endodontic Journal . https://doi.org/10.1111/iej.13449

Background The outcome of vital pulp treatment after carious pulp exposure is multifactorial and related to the procedure, biomaterial and pre-operative pulpal diagnosis. Objectives To conduct a systematic review and meta-analysis determining the out

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76b4b6fc4450e86b65583c2048e5071
https://doi.org/10.1111/iej.13449

A protocol for the Development of Core Outcome Sets for Endodontic Treatment modalities (COSET): an international consensus process

Autor: P. K. Shah, Henry F. Duncan, C. McLister, Mark Lappin, Bun San Chong, Casper Kruse, S. Cushley, Fionnuala Lundy, Venkateshbabu Nagendrababu, I. A. El Karim, Lise-Lotte Kirkevang, Mike Clarke

Publikováno v: Trials
El Karim, I A, Duncan, H F, Cushley, S, Nagendrababu, V, Kirkevang, L L, Kruse, C, Chong, B S, Shah, P K, Lappin, M, McLister, C, Lundy, F T & Clarke, M 2021, ' A protocol for the Development of Core Outcome Sets for Endodontic Treatment modalities (COSET) : an international consensus process ', Trials, vol. 22, 812 . https://doi.org/10.1186/s13063-021-05764-x
Trials, Vol 22, Iss 1, Pp 1-7 (2021)
El Karim, I A, Duncan, H F, Cushley, S, Nagendrababu, V, Kirkevang, L L, Kruse, C, Chong, B S, Shah, P K, Lappin, M, McLister, C, Lundy, F T & Clarke, M 2021, ' A protocol for the Development of CoreOutcome Sets for Endodontic Treatmentmodalities (COSET): an internationalconsensus process ', Trials, vol. 22, no. 1, pp. 812 . https://doi.org/10.1186/s13063-021-05764-x

Background The outcome of endodontic treatment is generally assessed using a range of patient and clinician-centred, non-standardised clinical and radiographic outcome measures. This makes it difficult to synthesise evidence for systematic analysis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8e007d037287f656f044fd5aa376a8
https://pubmed.ncbi.nlm.nih.gov/34789318

Outcome measures to assess the effectiveness of endodontic treatment for pulpitis and apical periodontitis for use in the development of European Society of Endodontology (ESE) S3 level clinical practice guidelines: A Protocol

Autor: Venkateshbabu Nagendrababu, Paul M. H. Dummer, Henry F. Duncan, I A El-Karim

Publikováno v: Duncan, H F, Nagendrababu, V, El Karim, I & Dummer, P M H 2021, ' Outcome measures to assess the effectiveness of endodontic treatment for pulpitis and apical periodontitis for use in the development of European Society of Endodontology (ESE) S3 level clinical practice guidelines: A Protocol ', International Endodontic Journal . https://doi.org/10.1111/iej.13501

The European Society of Endodontology (ESE) is in the process of developing S3Level Clinical Practice Guidelines for the treatment of pulpal and apical disease for the benefit of clinicians and patients. In order to ensure a homogenous review process

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c1eb12e9d13dc0c293efb939af6551
https://pure.qub.ac.uk/en/publications/6deb56e8-8092-41bf-80fa-97fe9d6d4c25

Odontoblast cell death induces NLRP3 inflammasome-dependent sterile inflammation and regulates dental pulp cell migration, proliferation and differentiation

Autor: P. N. Moynah, Y. Domberoski, Christopher Irwin, Imad About, I. A. El Karim, B. Al Natour, Fionnuala Lundy, Charlotte Jeanneau

Publikováno v: International Endodontic Journal
International Endodontic Journal, 2021
Al Natour, B, Lundy, F T, Moynah, P N, About, I, Jeanneau, C, Irwin, C, Dombrowski, Y & El Karim, I A 2021, ' Odontoblast cell death induces NLRP3 inflammasome-dependent sterile inflammation and regulates dental pulp cell migration, proliferation and differentiation ', International Endodontic Journal, vol. 54, no. 6, pp. 941-950 . https://doi.org/10.1111/iej.13483

Aim: To investigate the ability of dead odontoblasts to initiate NLRP3 inflammasome‐dependent sterile inflammation and to explore the effect on dental pulp cell (DPCs) migration, proliferation and odontogenic differentiation. Methods: Odontoblast�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170439457f2806def0143eebe248fb89
https://pubmed.ncbi.nlm.nih.gov/33503274