Zobrazeno 1 - 10
of 828
pro vyhledávání: '"I. Zon"'
Autor:
Haley R Noonan, Alexandra M Thornock, Julia Barbano, Michael E Xifaras, Chloe S Baron, Song Yang, Katherine Koczirka, Alicia M McConnell, Leonard I Zon
Publikováno v:
eLife, Vol 13 (2024)
Developmental signaling pathways associated with growth factors such as TGFb are commonly dysregulated in melanoma. Here we identified a human TGFb enhancer specifically activated in melanoma cells treated with TGFB1 ligand. We generated stable trans
Externí odkaz:
https://doaj.org/article/f51748881cd9498bbfd7139601c881b1
Autor:
Vera Binder, Wantong Li, Muhammad Faisal, Konur Oyman, Donn L. Calkins, Jami Shaffer, Emily M. Teets, Steven Sher, Andrew Magnotte, Alex Belardo, William Deruelle, T. Charles Gregory, Shelley Orwick, Elliott J. Hagedorn, Julie R. Perlin, Serine Avagyan, Asher Lichtig, Francesca Barrett, Michelle Ammerman, Song Yang, Yi Zhou, William E. Carson, Heather R. Shive, James S. Blachly, Rosa Lapalombella, Leonard I. Zon, Bradley W. Blaser
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112528- (2023)
Summary: Altered hematopoietic stem cell (HSC) fate underlies primary blood disorders but microenvironmental factors controlling this are poorly understood. Genetically barcoded genome editing of synthetic target arrays for lineage tracing (GESTALT)
Externí odkaz:
https://doaj.org/article/b0783af216d541e48c1e8e6815eda5bc
Autor:
Sahar Tavakoli, Vivian Garcia, Eric Gähwiler, Isaac Adatto, Apoorva Rangan, Kathleen A. Messemer, Sara Ashrafi Kakhki, Song Yang, Victoria S. Chan, Margot E. Manning, Haleh Fotowat, Yi Zhou, Amy J. Wagers, Leonard I. Zon
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112365- (2023)
Summary: Stem cell transplantation presents a potentially curative strategy for genetic disorders of skeletal muscle, but this approach is limited by the deleterious effects of cell expansion in vitro and consequent poor engraftment efficiency. In an
Externí odkaz:
https://doaj.org/article/e15cef7ae5ba4dcdbf25249bf15ca76b
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 8 (2022)
Spitz neoplasms are a diverse group of molecularly and histologically defined melanocytic tumors with varying biologic potentials. The precise classification of Spitz neoplasms can be challenging. Recent studies have revealed recurrent fusions involv
Externí odkaz:
https://doaj.org/article/dc462cf7d3294525bc57d2e3baa86590
Publikováno v:
Наукові горизонти, Vol 23, Iss 11, Pp 7-15 (2020)
The paper presents materials on pathomorphological changes in the organs of dogs with intestinal yersiniosis, the disease which is still considered to be predominately asymptomatic. The aim of the study was to determine the main pathomorphological ch
Externí odkaz:
https://doaj.org/article/bf20c207b74a47f186114c7c2d61a8a4
Publikováno v:
Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, Vol 22, Iss 99, Pp 161-166 (2020)
Canine yersiniosis is currently a scantily researched disease. Two agents predominately cause yersiniosis: Y. enterocolitica (gut yersiniosis), Y. preudotuberculosis (yersiniosis). There are three clinical forms of the disease: intestinal, generalize
Externí odkaz:
https://doaj.org/article/c3d9e98849c74aa19249402b574fb8dc
Autor:
Jiyeon Choi, Tongwu Zhang, Andrew Vu, Julien Ablain, Matthew M. Makowski, Leandro M. Colli, Mai Xu, Rebecca C. Hennessey, Jinhu Yin, Harriet Rothschild, Cathrin Gräwe, Michael A. Kovacs, Karen M. Funderburk, Myriam Brossard, John Taylor, Bogdan Pasaniuc, Raj Chari, Stephen J. Chanock, Clive J. Hoggart, Florence Demenais, Jennifer H. Barrett, Matthew H. Law, Mark M. Iles, Kai Yu, Michiel Vermeulen, Leonard I. Zon, Kevin M. Brown
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
There are more than 20 known melanoma susceptibility genes. Here, using a massively parallel reporter assay, the authors identify risk-associated variants that alter gene transcription, and demonstrate that expression of one such gene, MX2, leads to
Externí odkaz:
https://doaj.org/article/670b26b5d219499083d912a34bb1bf00
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0278302 (2022)
The zebrafish (Danio rerio) is among the most widely used model animals in scientific research. Historically, these fish have been reared in the laboratory using simple methods developed by home aquarists. For laboratories with high demand for breedi
Externí odkaz:
https://doaj.org/article/7e122ecbf6bf49eea4e9e5a8271be743
Autor:
Eva M Fast, Audrey Sporrij, Margot Manning, Edroaldo Lummertz Rocha, Song Yang, Yi Zhou, Jimin Guo, Ninib Baryawno, Nikolaos Barkas, David Scadden, Fernando Camargo, Leonard I Zon
Publikováno v:
eLife, Vol 10 (2021)
Hematopoietic stem cells (HSCs) must ensure adequate blood cell production following distinct external stressors. A comprehensive understanding of in vivo heterogeneity and specificity of HSC responses to external stimuli is currently lacking. We per
Externí odkaz:
https://doaj.org/article/2fe2e574cbf147d699ad25e6263b78b4
Autor:
Elena Gómez-Abenza, Sofía Ibáñez-Molero, Diana García-Moreno, Inmaculada Fuentes, Leonard I. Zon, Maria C. Mione, María L. Cayuela, Chiara Gabellini, Victoriano Mulero
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background Skin cutaneous melanoma (SKCM) is the most lethal form of skin cancer and while incidence rates are declining for most cancers, they have been steadily rising for SKCM. Serine protease inhibitor, kunitz-type, 1 (SPINT1) is a type
Externí odkaz:
https://doaj.org/article/7cbb66eb49a74c728868836425bdffab