Zobrazeno 1 - 10
of 251
pro vyhledávání: '"I. Melchers"'
Autor:
I Melchers
Publikováno v:
Zeitschrift für Rheumatologie. 70:192-197
Genetic risk factors are known to exist for all collagen vascular diseases. They are most important for systemic lupus erythematosus (SLE) and systemic scleroderma (SSc), as shown by the systematic analysis of family data. Both diseases to date share
Autor:
I. Melchers
Publikováno v:
Zeitschrift für Rheumatologie. 64:402-407
Publikováno v:
Clinical and Experimental Immunology. 132:366-370
SUMMARYThe tryptic FAD-peptide carrying the flavin in 8α-(N3)histidyl linkage as natural hapten was isolated by HPLC from the bacterial enzyme 6-hydroxy-d-nicotine oxidase. The same flavin protein linkage is found in the mitochondrial succinate dehy
Publikováno v:
Clinical and Experimental Immunology. 122:270-276
SUMMARYThe expression of CR2 (CD21) by synovial B and T lymphocytes of patients suffering from various forms of arthritis was analysed with cytofluorometry and with reverse transcriptase-polymerase chain reaction. CR2 (CD21) cell surface protein was
Publikováno v:
Journal of Autoimmunity. 13:83-87
Human B cell hybridomas were established to define new autoantigens of importance for autoimmune diseases such as rheumatoid arthritis (RA). One lgG1, lambda monoclonal antibody (FKN-E12), was derived from synovial B lymphocytes of a patient with ser
Autor:
S Martin, P Rieckmann, I Melchers, R Wagner, J Bertrams, A E Voskuyl, B O Roep, J Zielasek, E Heidenthal, I Weichselbraun
Publikováno v:
The Journal of Immunology. 154:1951-1955
The intercellular adhesion molecule-3 (ICAM-3) has been identified as the third LFA-1 ligand in addition to ICAM-1 and ICAM-2. In this report we have identified circulating forms of ICAM-3 (cICAM-3) in human serum. Using a sandwich ELISA with two mon
Autor:
I. Melchers, I. Weichselbraun, Alexandre E. Voskuyl, A. H. Zwinderman, S. Martin, F. C. Breedveld
Publikováno v:
Rheumatology. 34:311-315
The aim of this study was to investigate whether levels of circulating adhesion molecules reflect vascular inflammation in rheumatoid vasculitis (RV). Levels of circulating intercellular adhesion molecule-1 (cICAM-1), c-ICAM-3 and circulating endothe
Publikováno v:
Rheumatology International. 14:155-161
To investigate a possible relationship between the presence of anti-neutrophil cytoplasm antibodies (ANCA), rheumatoid factors (RF), anti-nuclear antibodies (ANA), disease severity and HLA-DR phenotypes, 46 consecutive ANCA+ and 48 ANCA-, clinically
Publikováno v:
Clinical and Experimental Immunology. 96:450-457
SUMMARYPrecursor frequencies for anti-DNA-secreting B cells were estimated in six healthy donors and 18 SLE patients with active and inactive disease. Precursors for IgG anti-dsDNA-secreting B cells were exclusively detected in SLE patients (73% of a
Autor:
I, Melchers
Publikováno v:
Zeitschrift fur Rheumatologie. 70(3)
Genetic risk factors are known to exist for all collagen vascular diseases. They are most important for systemic lupus erythematosus (SLE) and systemic scleroderma (SSc), as shown by the systematic analysis of family data. Both diseases to date share