Zobrazeno 1 - 7
of 7
pro vyhledávání: '"I-Farn Lei"'
Autor:
Patrick D. Lyden, I-Farn Lei, Jilin Bai, John H. Griffin, José A. Fernández, Padmesh S. Rajput, Jessica Lamb, Jennifer Leung, Benedict Pereira
Publikováno v:
Brain Res
Thrombin and activated protein C (APC) are known coagulation factors that exhibit profound effects in brain by acting on the protease activated receptor (PAR). The wild type (WT) proteases appear to impact cell survival powerfully, and therapeutic fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9225bd3ef5328307365b75855fe896
https://europepmc.org/articles/PMC6500472/
https://europepmc.org/articles/PMC6500472/
Autor:
Benedict Pereira, Padmesh S. Rajput, Lifu Zhao, Bo Chen, Jessica Lamb, Patrick D. Lyden, I-Farn Lei
Publikováno v:
Stroke. 45:896-899
Background and Purpose— We showed previously robust neuroprotection with the thrombin inhibitor argatroban and now sought additional support for its neuroprotective potential. Methods— We used behavioral and histological end points; rigorously bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190272a183b1f34e3641a4f77857e66d
https://doi.org/10.1161/strokeaha.113.004488
https://doi.org/10.1161/strokeaha.113.004488
Autor:
Padmesh S. Rajput, Patrick D. Lyden, Alexander W. Lamb, Bo Chen, Lifu Zhao, Benedict Pereira, Jilin Bai, Jessica Lamb, I-Farn Lei
Protease activated receptors (PARs) populate neurons and astrocytes in the brain. The serine protease thrombin, which activates PAR-1 during the first hours after stroke, appears to be associated with the cytotoxicity. Thrombin antagonists and PAR-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81651cb063974de5d682ba2107b0ac3f
https://europepmc.org/articles/PMC4377119/
https://europepmc.org/articles/PMC4377119/
Autor:
Michael A. Whitney, Beth Friedman, Lifu Zhao, Roger Y. Tsien, I-Farn Lei, Patrick D. Lyden, Jessica A. Van Winkle, Bo Chen, Qun Cheng, Emilia S. Olson, Benedict Pereira
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(22)
Mechanisms of ischemic neuronal and vascular injury remain obscure. Here we test the hypothesis that thrombin, a blood-borne coagulation factor, contributes to neurovascular injury during acute focal ischemia. Stroke was induced in adult Sprague Dawl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f474d917517701691afe9114eb754ba9
https://pubmed.ncbi.nlm.nih.gov/22649241
https://pubmed.ncbi.nlm.nih.gov/22649241
Publikováno v:
Stroke. 43
Background and Purpose- The role of thrombin in mediating cytotoxicity after intracerebral hemorrhage is well known. Recently, we demonstrated activated thrombin co-localizing with neurons after ischemia using immunohistochemistry (IHC). We sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f25530c98f0220208b540e594e34e4a7
https://doi.org/10.1161/str.43.suppl_1.a3041
https://doi.org/10.1161/str.43.suppl_1.a3041
Autor:
Lyden, Patrick, Pereira, Benedict, Bo Chen, Lifu Zhao, Lamb, Jessica, I-farn Lei, Rajput, Padmesh
Publikováno v:
Stroke (00392499); Mar2014, Vol. 45 Issue 3, p896-899, 4p
Autor:
Bo Chen, Friedman, Beth, Whitney, Michael A., Van Winkle, Jessica A., I-Farn Lei, Olson, Emilia S., Qun Cheng, Pereira, Benedict, Lifu Zhao, Tsien, Roger Y., Lyden, Patrick D.
Publikováno v:
Journal of Neuroscience; 5/30/2012, Vol. 32 Issue 22, p7622-7631, 10p