Zobrazeno 1 - 10
of 97
pro vyhledávání: '"I-BET151"'
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
I-BET151 is an inhibitor of bromodomain and extra-terminal domain (BET) proteins that selectively inhibits BET family members (BRD2, BRD3, BRD4, and BRDT). Over the past ten years, many studies have demonstrated the potential of I-BET151 in cancer tr
Externí odkaz:
https://doaj.org/article/b313a72a97bc4a68bd1908902c801be1
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Hyperuricemia is an independent risk factor for renal damage and promotes the progression of chronic kidney disease. In this study, we investigated the effect of I-BET151, a small-molecule inhibitor targeting the bromodomain and extraterminal (BET) p
Externí odkaz:
https://doaj.org/article/7dc004def88c4c0091841f249591158b
Autor:
Anna Maksylewicz, Agnieszka Bysiek, Katarzyna B. Lagosz, Justyna M. Macina, Malgorzata Kantorowicz, Grzegorz Bereta, Maja Sochalska, Katarzyna Gawron, Maria Chomyszyn-Gajewska, Jan Potempa, Aleksander M. Grabiec
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
BET bromodomain proteins are important epigenetic regulators of gene expression that bind acetylated histone tails and regulate the formation of acetylation-dependent chromatin complexes. BET inhibitors suppress inflammatory responses in multiple cel
Externí odkaz:
https://doaj.org/article/0bc3b211a3a74899bfdde83128968b24
Autor:
Pastori, Chiara, Kapranov, Philipp, Penas, Clara, Peschansky, Veronica, Volmar, Claude-Henry, Sarkaria, Jann N., Bregy, Amade, Komotar, Ricardo, St. Laurent, Georges, Ayad, Nagi G., Wahlestedt, Claes
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2015 Jul 01. 112(27), 8326-8331.
Externí odkaz:
https://www.jstor.org/stable/26463705
Autor:
Sina Sender, Ahmad Wael Sultan, Daniel Palmer, Dirk Koczan, Anett Sekora, Julia Beck, Ekkehard Schuetz, Leila Taher, Bertram Brenig, Georg Fuellen, Christian Junghanss, Hugo Murua Escobar
Publikováno v:
Cancers; Volume 14; Issue 19; Pages: 4691
Background: Both bromodomain and extra-terminal domain (BET) proteins and spleen tyrosine kinase (SYK) represent promising targets in diffuse large B-cell (DLBCL) and Burkitt’s lymphoma (BL). We evaluated the anti-lymphoma activity of the isoform-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc2497b63801b6a18f4d1af5d518b9e
Akademický článek
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Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology, Vol 11 (2021)
I-BET151 is an inhibitor of bromodomain and extra-terminal domain (BET) proteins that selectively inhibits BET family members (BRD2, BRD3, BRD4, and BRDT). Over the past ten years, many studies have demonstrated the potential of I-BET151 in cancer tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa37710de06713fd2942b5d5994b5159
https://doi.org/10.3389/fonc.2021.716830
https://doi.org/10.3389/fonc.2021.716830
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3022, p 3022 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences
Volume 22
Issue 6
This study aimed to identify alternative anti-inflammatory compounds that modulate the activity of a relevant transcription factor, CCAAT/enhancer binding protein delta (C/EBPδ). C/EBPδ is a master regulator of inflammatory responses in macrophages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12107705f4dbe4fcffae980f685ff5a6
https://www.mdpi.com/1422-0067/22/6/3022
https://www.mdpi.com/1422-0067/22/6/3022
Autor:
Trees Jansen, Rab K. Prinjha, Anaísa V Ferreira, Rebecca C. Furze, Nicholas Smithers, Mihai G. Netea, Jorge Domínguez-Andrés
Publikováno v:
European Journal of Immunology, 49, 2044-2050
European Journal of Immunology, 49, 11, pp. 2044-2050
European Journal of Immunology
European Journal of Immunology, 49, 11, pp. 2044-2050
European Journal of Immunology
Changes in the epigenetic landscape of immune cells are a crucial component of gene activation during the induction of inflammatory responses, therefore it has been hypothesized that epigenetic modulation could be employed to restore homeostasis in i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4375b4e76740131d3d10ff08c1165f10
https://doi.org/10.1002/eji.201848081
https://doi.org/10.1002/eji.201848081