Výsledky vyhledávání - "I van Seuningen"

Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells

Autor: Michael Perrais, Audrey Vincent, I. Van Seuningen, Jean-Luc Desseyn, Pascal Pigny, Jean-Pierre Aubert

Publikováno v: Oncogene
Oncogene, 2007, 26, pp.6566-6576. ⟨10.1038/sj.onc.1210479⟩
Oncogene, Nature Publishing Group, 2007, 26, pp.6566-6576. ⟨10.1038/sj.onc.1210479⟩

International audience; The human genes MUC2, MUC5AC, MUC5B and MUC6 are clustered on chromosome 11 and encode large secreted gel-forming mucins. The frequent occurrence of their silencing in cancers and the GC-rich structure of their promoters led u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299df5cc29dd0b1992903f37d0a77198
https://doi.org/10.1038/sj.onc.1210479

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miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer

Autor: Nicolas Jonckheere, Audrey Vincent, Y Delpu, Belinda Duchêne, J Torrisani, Fatima Lahdaoui, Emmanuelle Leteurtre, I. Van Seuningen, Mathieu Messager, Christophe Mariette, Florence Renaud

Publikováno v: Oncogene
Oncogene, 2015, 34, pp.780-788. ⟨10.1038/onc.2014.11⟩
Oncogene, Nature Publishing Group, 2015, 34, pp.780-788. ⟨10.1038/onc.2014.11⟩

International audience; Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers in the world with one of the worst outcome. The oncogenic mucin MUC4 has been identified as an actor of pancreatic carcinogenesis as it is involved in ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83be2d52772e75b7e311792df41bf36
https://hal.science/hal-02905857/file/ARTICLE.pdf

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Double rôle de MUC1 dans l’ischémie-reperfusion rénale

Autor: Brigitte Hémon, Michael Perrais, Viviane Gnemmi, Kelly Gaudelot, Sébastien Aubert, I. Van Seuningen, M. Fanchon, T. Swierczewski, Jean-Baptiste Gibier

Publikováno v: Néphrologie & Thérapeutique. 13:286

Introduction Le rein a des capacites uniques de regeneration mais les mecanismes impliques sont mal compris. La plasticite des cellules epitheliales tubulaires en reponse a une agression est essentielle pour la reparation des lesions tissulaires. Cep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::807bb2cf82ca3a5c4579a65f24828b48
https://doi.org/10.1016/j.nephro.2017.08.079

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The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family

Autor: Nicolas Skrypek, Belinda Duchêne, I. Van Seuningen, Nicolas Jonckheere, M Hebbar, Emmanuelle Leteurtre

Publikováno v: Oncogene
Oncogene, 2013, 32 (13), pp.1714-23. ⟨10.1038/onc.2012.179⟩
Oncogene, Nature Publishing Group, 2013, 32 (13), pp.1714-23. ⟨10.1038/onc.2012.179⟩

International audience; The fluorinated analog of deoxycytidine, Gemcitabine (Gemzar), is the main chemotherapeutic drug in pancreatic cancer, but survival remains weak mainly because of the high resistance of tumors to the drug. Recent works have sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6f0fa6f2f9f31e24d0bdd83c48188a
https://www.hal.inserm.fr/inserm-00807837

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The K Protein Domain That Recruits the Interleukin 1-responsive K Protein Kinase Lies Adjacent to a Cluster of c-Src and Vav SH3-binding Sites

Autor: Karol Bomsztyk, Jerzy Ostrowski, P R Sleath, Xosé R. Bustelo, I Van Seuningen

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1995, 270 (45), pp.26976-26985. ⟨10.1074/jbc.270.45.26976⟩

The heterogeneous ribonucleoprotein particle (hnRNP) K protein interacts with multiple molecular partners including DNA, RNA, serine/threonine, and tyrosine kinases and the product of the proto-oncogene, Vav. The K protein is phosphorylated in vivo a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72e878ba427594d9c0707ed55946e8c
https://doi.org/10.1074/jbc.270.45.26976

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