Zobrazeno 1 - 10 of 171 pro vyhledávání: '"I de Waziers"'
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The effect of Smallanthus sonchifolius leaf extracts on rat hepatic metabolism
Autor: Arlette Moncion, I de Waziers, Jitka Ulrichová, Kateřina Valentová
Publikováno v: Cell Biology and Toxicology. 20:109-120
Smallanthus sonchifolius (yacon), originating from South America, has become popular in Japan and in New Zealand for its tubers which contain beta-1,2-oligofructans as the main saccharides. The plant is also successfully cultivated in Central Europe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94163c9161bdbc32e9e9d4f5bba840ce
https://doi.org/10.1023/b:cbto.0000027931.88957.80
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4
Human CYP2B6
Autor: I de Waziers, Philippe Beaune, Laurence Gervot, V de Berardinis, H Martin, Bertrand Rochat, Heyo K. Kroemer, Jean-Charles Gautier, F Bohnenstengel
Publikováno v: Pharmacogenetics. 9:295-306
Human cytochrome (CYP)2B6 cDNA was cloned and expressed in bacteria and in yeast. Its expression in Saccharomyces cerevisiae enabled us to obtain, at a high level, an active yeast-expressed CYP2B6 protein, so as to assess its role in the metabolism o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0730f30ccee6c860d8acb8826d3af5eb
https://doi.org/10.1097/00008571-199906000-00004
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5
Cytochrome P450 mediated bioactivation of methyleugenol to 1'- hydroxymethyleugenol in Fischer 344 rat and human liver microsomes
Autor: Philippe Beaune, H. Wakazono, John Caldwell, I de Waziers, Iain Gardner, P Bergin, J G Kenna
Publikováno v: Carcinogenesis. 18:1775-1783
Cytochrome P450 mediated metabolism of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol has been investigated in vitro. Kinetic studies undertaken in liver microsomes from control male Fischer 344 rats revealed that this reaction is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9375126abc79ac8f51f7e4952860b1
https://doi.org/10.1093/carcin/18.9.1775
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6
The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: The case of ethylene dibromide
Autor: P.J. van Bladeren, L.W. Wormhoudt, Jan N. M. Commandeur, J.H.T.M. Ploemen, I de Waziers, M. J. Oudshoorn, Philippe Beaune, Nico P. E. Vermeulen, Guido R. M. M. Haenen, T. Watabe
Publikováno v: Ploemen, J P H T M, Wormhoudt, L W, Haenen, G R M M, Oudshoorn, M J, Commandeur, J N M, Vermeulen, N P E, De Waziers, I, Beaune, P H, Watabe, T & van Bladeren, P J 1997, ' The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: The case of ethylene dibromide. ', Toxicology and Applied Pharmacology, vol. 143, pp. 56-69 . https://doi.org/10.1006/taap.1996.8004
Toxicology and Applied Pharmacology, 143, 56-69
Toxicology and Applied Pharmacology, 143, 56-69. Academic Press Inc.
Toxicology and Applied Pharmacology 143 (1997)
Ethylene dibromide (1,2-dibromoethane, EDB) is metabolized by two routes: a conjugative route catalyzed by glutathione S -transferases (GST) and an oxidative route catalyzed by cytochrome P450 (P450). The GST route is associated with carcinogenicity.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e60055c883c300fa9084d2934522198
https://hdl.handle.net/1871/24904
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7
Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes
Autor: Jan N. M. Commandeur, L.W. Wormhoudt, Philippe Beaune, P.J. van Bladeren, Nico P. E. Vermeulen, I de Waziers, J.H.T.M. Ploemen
Publikováno v: Chemico-Biological Interactions, 101, 175-192. Elsevier Ireland Ltd
Wormhoudt, L W, Ploemen, J P H T M, de Waziers, I, Commandeur, J N M, Beaune, P H, van Bladeren, P J & Vermeulen, N P E 1996, ' Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes. ', Chemico-Biological Interactions, vol. 101, pp. 175-192 . https://doi.org/10.1016/0009-2797(96)03723-4
Chemico-Biological Interactions, 3, 101, 175-192
1,2-Dibromoethane (1,2-DBE) is mainly used as an additive in leaded gasoline and as a soil fumigant and it is a suspected carcinogen in humans. In this study, the oxidative bioactivation of 1,2-DBE to 2-bromoacetaldehyde (2-BA) was studied using hete
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a765cf714c59df7650460fa8061ed490
https://doi.org/10.1016/0009-2797(96)03723-4
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8
Presence of proteins recognized by mammalian cytochrome P-450 antibodies in Euglena gracilis
Autor: Philippe Beaune, Joël Briand, Heddy Julistiono, Jean-Pierre Flinois, Jean-Paul Leroux, I de Waziers
Publikováno v: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1203:199-204
We have attempted to probe three microsomal cytochrome P-450 isozymes in Euglena gracilis using immunochemical methods. They cross-react with anti-rat cytochrome P4502C11, cytochrome P4502E, and cytochrome P4502B. Activities of alkoxyphenoxazone deal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b0c6910344363efc92e53a37e83dbb
https://doi.org/10.1016/0167-4838(93)90083-4
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9
Cytochrome P450 induction and mutagenicity of 2-aminoanthracene (2AA) in rat liver and gut
Autor: Philippe Beaune, Y.A. Courtois, I de Waziers, Véronique Carrière, J.-P. Leroux
Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 268:11-20
The aim of our study was to establish a relationship between the ability of rat liver and gut to activate 2-aminoanthracene (2AA) into mutagens and their P450 enzyme composition. Rats were orally pretreated with beta-naphthoflavone (beta NF), phenoba
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aea1186f21565ffe7110f12009a5c62
https://doi.org/10.1016/0027-5107(92)90077-f
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10
Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples
Autor: Anne Berger, Paul-Henri Cugnenc, I de Waziers, Philippe Beaune, Jean-Paul Leroux
Publikováno v: Carcinogenesis. 12:905-909
In the present study, we investigated Phase I (cytochrome P450; DT-diaphorase, DTD) and Phase II (epoxide hydrolase, EH; glutathione-S-transferases, GSTs) enzymes in normal colon from patients without colorectal adenocarcinoma and in peritumoral and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24365a997c4f43daec07bd536bcbd61
https://doi.org/10.1093/carcin/12.5.905
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