Zobrazeno 1 - 10
of 154
pro vyhledávání: '"I W Morgan"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Adaptive optics ophthalmoscopy has enabled visualization of the in vivo human photoreceptor mosaic in health, disease and its treatment. Despite this, the clinical utility of the imaging technology has been limited by a lack of automated ana
Externí odkaz:
https://doaj.org/article/8f94a46e8d6a4d32ba87d8044032f5a7
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Choroideremia (CHM) is an X-linked retinal degeneration leading to loss of the photoreceptors, retinal pigment epithelium (RPE), and choroid. Adaptive optics optoretinography is an emerging technique for noninvasive, objective assessment of
Externí odkaz:
https://doaj.org/article/48b9f5b9891e40a596d9330206a721f6
Autor:
Artur V. Cideciyan, Alejandro J. Roman, Raymond L. Warner, Alexander Sumaroka, Vivian Wu, Yu Y. Jiang, Malgorzata Swider, Alexandra V. Garafalo, Iryna Viarbitskaya, Robert C. Russell, Susanne Kohl, Bernd Wissinger, Caterina Ripamonti, John L. Barbur, Michael Bach, Joseph Carroll, Jessica I. W. Morgan, Tomas S. Aleman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10639 (2024)
L-cone opsin expression by gene therapy is a promising treatment for blue cone monochromacy (BCM) caused by congenital lack of long- and middle-wavelength-sensitive (L/M) cone function. Eight patients with BCM and confirmed pathogenic variants at the
Externí odkaz:
https://doaj.org/article/34832f17630c493e803a7a454e223355
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Externí odkaz:
https://doaj.org/article/d1cd62e88cc240ce913d79a7be26d7dc
Publikováno v:
Biomed Opt Express
Twenty-five years ago, adaptive optics (AO) was combined with fundus photography, thereby initiating a new era in the field of ophthalmic imaging. Since that time, clinical applications of AO ophthalmoscopy to investigate visual system structure and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cb501354bff6af34b19ded1b25ef01
https://europepmc.org/articles/PMC9841996/
https://europepmc.org/articles/PMC9841996/
Autor:
Emma Bedoukian, Katherine E. Uyhazi, Leona W. Serrano, Jessica I. W. Morgan, Robert F. Cooper, Michael J. Ammar, Priyanka Kumar, Kurt T. Scavelli, Ilaina D. Edelstein, Tomas S. Aleman, Grace Vergilio
Publikováno v:
Retin Cases Brief Rep
PURPOSE: To describe in detail the phenotype of a patient with enhanced S-cone syndrome. METHODS: We describe a 13-year-old boy who presented with blurred vision, vitreous cells, cystoid macular edema refractory to steroid treatment, and a negative u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aba45ef373f2809b91c9306477f65bb
https://doi.org/10.1097/icb.0000000000000891
https://doi.org/10.1097/icb.0000000000000891
Autor:
Jessica I. W. Morgan, Erin C O'Neil, Brian W Toussaint, Keli O'Connor, Yu You Jiang, Jean Bennett, Tomas S. Aleman, Isabella A. Aleman
Publikováno v:
Ophthalmic Genet
PURPOSE: To provide a detailed ophthalmic phenotype of two male patients with Bardet-Biedl Syndrome (BBS) due to mutations in the BBS7 gene METHODS: Two brothers ages 26 (Patient 1, P1) and 23 (P2) underwent comprehensive ophthalmic evaluations over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af366cbdffb352c845ab0854023a71b
https://doi.org/10.1080/13816810.2021.1888132
https://doi.org/10.1080/13816810.2021.1888132
Publikováno v:
Translational vision sciencetechnology. 11(5)
Adaptive optics scanning laser ophthalmoscopy (AOSLO) is a high-resolution imaging modality that allows measurements of cellular-level retinal changes in living patients. In retinal diseases, the visibility of photoreceptors in AOSLO images is affect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6bca9a8a43cd8a90d7cc3b2e6e659b
https://pubmed.ncbi.nlm.nih.gov/35608855
https://pubmed.ncbi.nlm.nih.gov/35608855
Autor:
Tomas S, Aleman, Rachel M, Huckfeldt, Leona W, Serrano, Denise J, Pearson, Grace K, Vergilio, Sarah, McCague, Kathleen A, Marshall, Manzar, Ashtari, Tu M, Doan, Carol A, Weigel-DiFranco, Bethany S, Biron, Xiao-Hong, Wen, Daniel C, Chung, Emily, Liu, Kevin, Ferenchak, Jessica I W, Morgan, Eric A, Pierce, Dean, Eliott, Jean, Bennett, Jason, Comander, Albert M, Maguire
Publikováno v:
Ophthalmology. 129(10)
To assess the safety of the subretinal delivery of a recombinant adeno-associated virus serotype 2 (AAV2) vector carrying a human choroideremia (CHM)-encoding cDNA in CHM.Prospective, open-label, nonrandomized, dose-escalation, phase I/II clinical tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::175d44fa052beacd88edf6041f266d41
https://pubmed.ncbi.nlm.nih.gov/35714735
https://pubmed.ncbi.nlm.nih.gov/35714735
Autor:
Tomas S. Aleman, Jessica I. W. Morgan, Denise J. Pearson, Grace Vergilio, Albert M. Maguire, Yu You Jiang, Leona W. Serrano, Jean Bennett
Subretinal injection for gene augmentation in retinal degenerations forcefully detaches the neural retina from the retinal pigment epithelium (RPE), potentially damaging photoreceptors and/or RPE cells. Here, we use adaptive optics scanning light oph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ae24a1c12ce096e422fcdb842b41ba8
https://doi.org/10.1101/2021.09.17.459817
https://doi.org/10.1101/2021.09.17.459817