Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: the pilot phase of a randomised controlled trial

Autor: C. J. Vickery, M. J. Lamparelli, R. Gupta, G. Maskell, A. C. Bateman, M. L. Hughes, Michael Braun, D. A. Agbamu, H. O'Neill, J. H. Scholefield, W. Faux, A. S. Myint, C. Macklin, H. J. Pearson, P. Richman, Geraint T. Williams, S. Sukumar, A. Kawesha, J. Robinson, Dion Morton, Caroline Finlayson, M. Saeed, A. Anathhanam, D. M. Melville, J. Whalley, Rizvana Ahmad, V. Howarth, E. Favill, Jacob G. Scott, M. Scott, D. Eason, S. M. Ahmad, Rajarshi Roy, M. Gupta, F. Lofts, N. Beharry, N. Lees, M. Charig, A. Buxton, Fiona Campbell, K. G. Walker, M. Train, P. Nichols, J. Mathew, G. Stenhouse, J. Orrell, P. Burn, D. Peake, S. P. Lake, D. Ilsley, A. J. Watson, A Mayer, A C Wotherspoon, David J. Smith, A. K. Thompson, J. Gutmann, W. K. Dunn, J. Huang, Tracy E Roberts, L. Meleagros, D. Cowlishaw, Angela E Taylor, P. Chandran, C. Bronder, B. Fozard, Jurjees Hasan, S. J. Needham, Rob Glynne-Jones, Jonathan Wadsley, F. Adab, J. Ostrowski, Andrew Bateman, I. T. Saeed, David Cunningham, E. Loveday, David Ferry, A. Hartley, K. Sleigh, A. Page, I. C. Ilesley, P. Cohen, D. Whillis, Phillipe Taniere, Paul J. Finan, S. Pritchard, S. Lee, A. Zaitoun, J. A. Rees, G. Langman, G. Howarth, D. Pai, D. Blunt, R. Osborne, W. Atkinson, D. Barber, O. A. Ogunbiyi, J. Harrison, H. Burnett, V. Sundaresan, S. Hayes, J. Livingstone, Simon Gollins, F. Daniel, G. Kurien, C. Holland, I. Britton, A. Sherif, Clifton D. Fuller, D. Shareef, Matthew T. Seymour, J. McCutcheon, C. Phelan, Charles Lowdell, R. M. Blaquiere, J. Alexander, A. Hamid, Sherif Raouf, A. Baxter, Tamas Hickish, Joanne Hornbuckle, A. Pallan, J. R.G. Bell, Graham Branagan, D. Tolan, A. Moss, J. Hampton, C. W. Hendrickse, D. Furniss, T. Burdge, Carolyn S. Hall, J. Watkins, C. Barlow, J. Hartley, P. Rooney, B. Pravee, Anne Pullyblank, C. Corr, A. Chiphang, J. Walther, Paris P. Tekkis, M. J. Dworkin, D. Eaton, R. Hagger, J. Mikel, A. Coup, M. Peters, S. Muzaffar, Sujal R. Desai, D. Tarver, C. Ramsey, Sarah Smith, J. Geraghty, N. Mapstone, Corran Roberts, John Bridgewater, S. Amin, P. Dawson, Vanessa Potter, C. J. Walsh, M. Pitt, N. Woodcock, S. Ramesh, Charlotte Rees, Nigel Scott, N. Steven, A. Maw, D. P. O'Leary, David Farrugia, S. Cook, D. Tsang, M. Callaway, P. Taylor, Andrew J. Hall, S. R. Muthuramalingam, S. A.M. Mangalika, N. Cruickshank, U. Raja, M. Dobson, C. Bale, R. W. Talbot, M. Qaiyum, M. Crabtree, Stephen H D Jackson, J. Hyde, S. Snape, Richard J. Ellis, R. Borgstein, A. Higginson, M. Thyveetil, Michael Thomas, A. Lowe, W. Partridge, Gina Brown, A. W. MacDonald, O. Lalude, M. Clwyd, Brendan J. Moran, G. T. Smith, Samir Mehta, B. T. Ismail, R. Donovan, P. Kitsanta, E. Kweka, N. Scot, K. Hopkins, N. Rooney, A. L. Desai, S. Jain, N. Wong, T. Iveson, Rubin Soomal, R. D. Taraporewalla, A. Clarke, J. Brittenden, S. Dundas, Marcia Hall, J. Denson, N. Day, Simon Aird Grumett, R. Church, M. Zeiderman, M. Steward, Daniel Swinson, S. Susnerwala, Stephen Falk, A. Malhotra, D. White, N. Pranesh, J. Haselden, James Hill, D. Scullion

Publikováno v: The Lancet Oncology. 13:1152-1160

Background Preoperative (neoadjuvant) chemotherapy and radiotherapy are more effective than similar postoperative treatment for oesophageal, gastric, and rectal cancers, perhaps because of more effective micrometastasis eradication and reduced risk o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c179d79bec2b424eaa6df5c9ef3b22
https://doi.org/10.1016/s1470-2045(12)70348-0

Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants

Autor: I T Saeed, Benjamin A. Onwuegbusi, Michael J.G. Farthing, W R Burnham, Rebecca C. Fitzgerald, Mona Bajaj-Elliott

Publikováno v: Gut. 50:451-459

Background and aims: Approximately 10% of adults experience gastro-oesophageal reflux symptoms with a variable oesophageal response. A total of 60% have no endoscopic abnormality, 30% have oesophagitis, and 10% have Barrett9s oesophagus. We investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f73db07160c8ec5eba3c6d468540ce
https://doi.org/10.1136/gut.50.4.451

Inflammatory gradient in Barrett's oesophagus: implications for disease complications

Autor: Benjamin A. Onwuegbusi, Michael J.G. Farthing, S Abdalla, Rebecca C. Fitzgerald, I T Saeed, W R Burnham, P Sirieix

Publikováno v: Gut. 51(3)

Introduction: Barrett’s oesophageal epithelium (BE) is clinically important due to the associated inflammatory and malignant complications which are unevenly distributed throughout the BE segment. As the immunoregulatory environment may influence d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af25b16226a59fa2767c4fbffadd0de
https://pubmed.ncbi.nlm.nih.gov/12171950

Rigorous surveillance protocol increases detection of curable cancers associated with Barrett's esophagus

Autor: R C, Fitzgerald, I T, Saeed, D, Khoo, M J, Farthing, W R, Burnham

Publikováno v: Digestive diseases and sciences. 46(9)

Esophageal adenocarcinoma is increasing in incidence and has a high mortality unless detected early. Barrett's esophagus is the only known risk factor for this cancer; however, whether endoscopic surveillance reduces morbidity and mortality is contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8eed875e7e772dbc0efbd1cbb2fe35ee
https://pubmed.ncbi.nlm.nih.gov/11575441

A fatal case of pleural osteosarcoma mimicking mesothelioma in Paget's disease of bone

Autor: I T Saeed, K Chakravarty, R W Fowler

Publikováno v: Rheumatology. 42:1578-1579

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::483e4cb48638dba0fb3df53646d7d10a
https://doi.org/10.1093/rheumatology/keg428