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Proteomics identification of radiation-induced changes of membrane proteins in the rat model of arteriovenous malformation in pursuit of targets for brain AVM molecular therapy

Autor: Rachel R. Ogorzalek Loo, David Bervini, Michael Grace, Joseph A. Loo, Mark P. Molloy, Dyna I. Shirasaki, Margaret Simonian, Marcus A. Stoodley, Vivienne S. Lee

Publikováno v: Simonian, Margaret; Shirasaki, Dyna; Lee, Vivienne S.; Bervini, David; Grace, Michael; Ogorzalek Loo, Rachel R.; Loo, Joseph A.; Molloy, Mark P.; Stoodley, Marcus A. (2018). Proteomics identification of radiation-induced changes of membrane proteins in the rat model of arteriovenous malformation in pursuit of targets for brain AVM molecular therapy. Clinical proteomics, 15(43), p. 43. BioMed Central 10.1186/s12014-018-9217-x
Clinical Proteomics
Clinical Proteomics, Vol 15, Iss 1, Pp 1-8 (2018)

Background Rapid identification of novel targets and advancement of a vascular targeting strategy requires a comprehensive assessment of AVM endothelial membrane protein changes in response to irradiation. The aim of this study is to provide addition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a4d9f553fc33f6293bb9c1af6d83b2

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Characterization of Saccharomyces cerevisiae Coenzyme Q Biosynthetic Protein Coq11

Autor: Joseph A. Loo, Dyna I. Shirasaki, Michelle C. Bradley, Agape M. Awad, Crysten E. Blaby-Haas, Catherine F. Clarke, Jarrett S. Johnson, Christopher M. Allan, Charles Wang

Publikováno v: The FASEB Journal. 31

Coenzyme Q, also known as ubiquinone or Q, is a redox-active lipid component of the electron transport chain that functions in cellular energy metabolism. Due to its redox capabilities reduced Q (o...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f81708b4ce447f749e343239f21013f9
https://doi.org/10.1096/fasebj.31.1_supplement.781.9

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Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice

Autor: Véronique M. André, Irene Yamazaki, Michelle Gray, Jifang Tao, Yi E. Sun, Carlos Cepeda, Shihua Li, Xiao-Hong Lu, Xiao-Jiang Li, Dyna I. Shirasaki, Michael Levine, Brian Wilburn, X. William Yang

Publikováno v: Journal of Neuroscience. 28:6182-6195

To elucidate the pathogenic mechanisms in Huntington's disease (HD) elicited by expression of full-length human mutant huntingtin (fl-mhtt), a bacterial artificial chromosome (BAC)-mediated transgenic mouse model (BACHD) was developed expressing fl-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbd1e520ec63cdd9214103b834d3172
https://doi.org/10.1523/jneurosci.0857-08.2008

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Characterization of Proteins Associated with the Coenzyme Q Biosynthetic Complex and Analyses of Phosphorylated Coq Proteins in Yeast Mitochondria

Autor: Dyna I. Shirasaki, Jarrett S. Johnson, Catherine F. Clarke, Christopher M. Allan, Joseph A. Loo, Agape M. Awad

Publikováno v: The FASEB Journal. 29

Coenzyme Q (also termed ubiquinone or CoQ) is an electron carrier in the mitochondrial respiratory chain that functions as an essential component in energy metabolism and serves as a vital lipid so...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3230706a5aedf7a4f5b2fced771b6b64
https://doi.org/10.1096/fasebj.29.1_supplement.568.29

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Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas

Autor: Timothy L. Stemmler, Jefferson Y. Chan, Dyna I. Shirasaki, Christopher J. Chang, Dylan W. Domaille, Janette Kropat, Sheel C. Dodani, Sean D. Gallaher, Dulmini Barupala, Peter K. Weber, Jennifer Pett-Ridge, Sabeeha S. Merchant, Joseph A. Loo, Anne Hong-Hermesdorf, Marcus Miethke

Publikováno v: Nature chemical biology, vol 11, iss 3
Nature chemical biology, vol 10, iss 12
Nature chemical biology
Hong-Hermesdorf, A; Miethke, M; Gallaher, SD; Kropat, J; Dodani, SC; Chan, J; et al.(2014). Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas. Nature chemical biology, 10(12), 1034-1042. doi: 10.1038/nchembio.1662. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/7sf6z8m7

We identified a Cu-accumulating structure with a dynamic role in intracellular Cu homeostasis. During Zn limitation, Chlamydomonas reinhardtii hyperaccumulates Cu, a process dependent on the nutritional Cu sensor CRR1, but it is functionally Cu defic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a338817a75d876ddefe14f2ba9a5cf68
https://escholarship.org/uc/item/4kg5j6tm

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Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae

Autor: Sabeeha S. Merchant, Catherine F. Clarke, Joseph A. Loo, Agape M. Awad, Dyna I. Shirasaki, Christopher M. Allan, Charles Wang, Jarrett S. Johnson, Crysten E. Blaby-Haas

Publikováno v: The Journal of biological chemistry, vol 290, iss 12

Coenzyme Q (Q or ubiquinone) is a redox active lipid composed of a fully substituted benzoquinone ring and a polyisoprenoid tail and is required for mitochondrial electron transport. In the yeast Saccharomyces cerevisiae, Q is synthesized by the prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf8ad59961b23eaf38dd53016642351
https://escholarship.org/uc/item/1r8691p9

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Characterization of proteins associated with a coenzyme Q biosynthetic complex in yeast mitochondria (605.19)

Autor: Catherine F. Clarke, Dyna I. Shirasaki, Christopher M. Allan, Joseph A. Loo, Jarrett S. Johnson

Publikováno v: The FASEB Journal. 28

Coenzyme Q (Q) is a fully substituted benzoquinone lipid crucial to the respiratory electron transport chain where it transfers electrons from NADH and succinate to cytochrome c. In the yeast Sacch...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4420541f4c485a177082f9f1a0b40bf
https://doi.org/10.1096/fasebj.28.1_supplement.605.19

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Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease

Autor: Michelle Gray, Carlos Cepeda, Dyna I. Shirasaki, Erin R. Greiner, Jeffrey P. Cantle, Xiao-Hong Lu, Sandra M. Holley, Xiaofeng Gu, Hong-Wei Dong, X. William Yang, Nan Wang, Michael Levine, Yuqing Li

Publikováno v: Nature medicine. 20(5)

Huntington's disease (HD) is a fatal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion leading to an elongated polyglutamine stretch in huntingtin. Mutant huntingtin (mHTT) is ubiquitously expressed in all cells but eli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06896e9ac9af835cbab16c7aa57473ad
https://pubmed.ncbi.nlm.nih.gov/24824179

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