Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient

Autor: I S Owens, Matthew T. Yeatman, Joseph K. Ritter, P Ferreira

Publikováno v: The Journal of clinical investigation. 90(1)

Patients with Crigler-Najjar syndrome (CN) type I inherit an autosomal recessive trait for hyperbilirubinemia, which is characterized by the total absence of bilirubin UDP-glucuronosyltransferase (transferase) activity. The recent identification of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b2120a2f612005c2426ff2abbb8a31
https://pubmed.ncbi.nlm.nih.gov/1634606

Gene structure at the human UGT1 locus creates diversity in isozyme structure, substrate specificity, and regulation

Autor: I S, Owens, J K, Ritter

Publikováno v: Progress in nucleic acid research and molecular biology. 51

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a32c914786c810c2a9184a8b19c50e6c
https://pubmed.ncbi.nlm.nih.gov/7659777

A phenylalanine codon deletion at the UGT1 gene complex locus of a Crigler-Najjar type I patient generates a pH-sensitive bilirubin UDP-glucuronosyltransferase

Autor: J K, Ritter, M T, Yeatman, C, Kaiser, B, Gridelli, I S, Owens

Publikováno v: The Journal of biological chemistry. 268(31)

The characterization (Ritter, J. K., Chen, F., Sheen, Y. Y., Tran, H. M., Kimura, S., Yeatman, M. T., and Owens, I. S. (1992) J. Biol. Chem. 267, 3257-3261) of the single-copy UGT1 gene complex encoding both bilirubin and phenol UDP-glucuronosyltrans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87189824bde1b2d254e7d3879d07c471
https://pubmed.ncbi.nlm.nih.gov/8226884

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells

Autor: J K, Ritter, J M, Crawford, I S, Owens

Publikováno v: The Journal of biological chemistry. 266(2)

We report the isolation and characterization of two human liver cDNA clones, HUG-Br1 and HUG-Br2; each encodes a UDP-glucuronosyltransferase enzyme which glucuronidates bilirubin IX alpha to form both the IX alpha C8 and IX alpha C12 monoconjugates a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ae59aebcaeb6045f65031f6e84b158c
https://pubmed.ncbi.nlm.nih.gov/1898728

2,4‐Dihydroxybenzoic Acid, a Novel SA Derivative, Controls Plant Immunity via UGT95B17‐Mediated Glucosylation: A Case Study in Camellia Sinensis.

Autor: Lu, Mengqian¹ (AUTHOR), Zhao, Yifan¹ (AUTHOR), Feng, Yingying¹ (AUTHOR), Tang, Xiaoyan¹ (AUTHOR), Zhao, Wei¹ (AUTHOR), Yu, Keke¹ (AUTHOR), Pan, Yuting¹ (AUTHOR), Wang, Qiang¹ (AUTHOR), Cui, Jilai^1,2 (AUTHOR), Zhang, Mengting¹ (AUTHOR), Jin, Jieyang¹ (AUTHOR), Wang, Jingming¹ (AUTHOR), Zhao, Mingyue¹ (AUTHOR), Schwab, Wilfried^1,3 (AUTHOR), Song, Chuankui¹ (AUTHOR) cksong@ahau.edu.cn

Publikováno v: Advanced Science. 2/16/2024, Vol. 11 Issue 7, p1-16. 16p.