Zobrazeno 1 - 10
of 29
pro vyhledávání: '"I Russel Lee"'
Autor:
Xuan Ying Poh, I. Russel Lee, Chee Wah Tan, Jean-Marc Chavatte, Siew Wai Fong, Yun Shan Goh, Angeline Rouers, Nathan Wong, Anthony Torres-Ruesta, Shirley Y.Y. Mah, Aileen Y.Y. Yeoh, Mihir Gandhi, Nabilah Rahman, Yi Qing Chin, J. Jonathan Lim, Terence J.K. Yoong, Suma Rao, Po Ying Chia, Sean W.X. Ong, Tau Hong Lee, Sapna P. Sadarangani, Ray J.H. Lin, Daniel R.X. Lim, Wanni Chia, Laurent Renia, Ee Chee Ren, Raymond T.P. Lin, David C. Lye, Lin-Fa Wang, Lisa F.P. Ng, Barnaby E. Young
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105275- (2024)
Summary: Background: Understanding how SARS-CoV-2 breakthrough infections impacts the breadth of immune responses against existing and pre-emergent SARS-CoV-2 strains is needed to develop an evidence-based long-term immunisation strategy. Methods: We
Externí odkaz:
https://doaj.org/article/4ec8750f0a144a5283fffeb6b9790a82
Autor:
Yun Shan Goh, Siew‐Wai Fong, Pei Xiang Hor, Chiew Yee Loh, Matthew Zirui Tay, Bei Wang, Siti Nazihah Mohd Salleh, Eve Zi Xian Ngoh, Raphael Tze Chuen Lee, Xuan Ying Poh, I. Russel Lee, Suma Rao, Po Ying Chia, Sebastian Maurer-Stroh, Cheng-I Wang, Yee‐Sin Leo, David C. Lye, Barnaby Edward Young, Lisa F.P. Ng, Laurent Renia
Publikováno v:
International Journal of Infectious Diseases, Vol 146, Iss , Pp 107147- (2024)
Objectives: The emergence of new SARS-CoV-2 variants has led to the development of Omicron-targeting bivalent mRNA vaccines. It is crucial to understand how bivalent vaccines may improve antibody responses against new variants. Methods: A total of 10
Externí odkaz:
https://doaj.org/article/10a40254e10745f0b29910119928a1bb
Autor:
I Russel Lee, Liting Yang, Gaseene Sebetso, Rebecca Allen, Thi H N Doan, Ross Blundell, Edmund Y L Lui, Carl A Morrow, James A Fraser
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64292 (2013)
Degradation of purines to uric acid is generally conserved among organisms, however, the end product of uric acid degradation varies from species to species depending on the presence of active catabolic enzymes. In humans, most higher primates and bi
Externí odkaz:
https://doaj.org/article/a53d16f2bfc6468f9f5bf863f9ab9025
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32585 (2012)
Nitrogen source utilization plays a critical role in fungal development, secondary metabolite production and pathogenesis. In both the Ascomycota and Basidiomycota, GATA transcription factors globally activate the expression of catabolic enzyme-encod
Externí odkaz:
https://doaj.org/article/3d3517c6d7434856947ca9f070997509
Autor:
Carl A Morrow, Eugene Valkov, Anna Stamp, Eve W L Chow, I Russel Lee, Ania Wronski, Simon J Williams, Justine M Hill, Julianne T Djordjevic, Ulrike Kappler, Bostjan Kobe, James A Fraser
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002957 (2012)
We have investigated the potential of the GTP synthesis pathways as chemotherapeutic targets in the human pathogen Cryptococcus neoformans, a common cause of fatal fungal meningoencephalitis. We find that de novo GTP biosynthesis, but not the alterna
Externí odkaz:
https://doaj.org/article/33cc5f6ca2e241689d79d1cbab96ad8a
Autor:
I. Russel Lee, Steven Y. C. Tong, Joshua S. Davis, David L. Paterson, Sharifah F. Syed-Omar, Kwong Ran Peck, Doo Ryeon Chung, Graham S. Cooke, Eshele Anak Libau, Siti-Nabilah B. A. Rahman, Mihir P. Gandhi, Luming Shi, Shuwei Zheng, Jenna Chaung, Seow Yen Tan, Shirin Kalimuddin, Sophia Archuleta, David C. Lye
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background The incidence of Gram-negative bacteraemia is rising globally and remains a major cause of morbidity and mortality. The majority of patients with Gram-negative bacteraemia initially receive intravenous (IV) antibiotic therapy. How
Externí odkaz:
https://doaj.org/article/253c69f328114ff886045878b6aee562
Autor:
James S. Molton, I. Russel Lee, Denis Bertrand, Ying Ding, Shirin Kalimuddin, David C. Lye, Niranjan Nagarajan, Yunn-Hwen Gan, Sophia Archuleta
Publikováno v:
International Journal of Infectious Diseases, Vol 107, Iss , Pp 1-4 (2021)
Objectives: Hypermucoviscous Klebsiella pneumoniae is an emerging cause of community-acquired liver abscess. The aim of this study was to investigate whether hypermucoviscous strains could be shared among households. Methods: The clinical K. pneumoni
Externí odkaz:
https://doaj.org/article/c6458c52c7904e3b89652ab5001be7d1
Autor:
Xuan Ying Poh, Chee Wah Tan, I Russel Lee, Jean-Marc Chavatte, Siew-Wai Fong, Tessa Prince, Catherine Hartley, Aileen Y Y Yeoh, Suma Rao, Po Ying Chia, Sean W X Ong, Tau Hong Lee, Sapna P Sadarangani, Ray J H Lin, Clarissa Lim, Jefanie Teo, Daniel R X Lim, Wanni Chia, Julian A Hiscox, Lisa F P Ng, Ee Chee Ren, Raymond T P Lin, Laurent Renia, David Chien Lye, Lin-Fa Wang, Barnaby E Young
Publikováno v:
Clinical Infectious Diseases. 75:2088-2096
Background Waning antibody levels post-vaccination and the emergence of variants of concern (VOCs) capable of evading protective immunity have raised the need for booster vaccinations. However, which combination of coronavirus disease 2019 (COVID-19)
Autor:
I. Russel Lee, Tun-Linn Thein, David C. Lye, Li Wei Ang, Christina Titin, Ying Ding, Shilpa Mukherjee, Chwee Fang Bok, Sophia Archuleta, Jonathan J Lim, Shirin Kalimuddin
Publikováno v:
Journal of Antimicrobial Chemotherapy. 76:1303-1310
BackgroundCeftriaxone is the preferred treatment for bacteraemia caused by non-MDR (antibiotic-susceptible) Klebsiella pneumoniae. Excessive and widespread ceftriaxone use creates selection pressure for ESBLs. Cefazolin is an alternative, although th
Autor:
Xuan Ying Poh, I. Russel Lee, Clarissa Lim, Jefanie Teo, Suma Rao, Po Ying Chia, Sean W. X. Ong, Tau Hong Lee, Ray J. H. Lin, Lisa F. P. Ng, Ee Chee Ren, Raymond T. P. Lin, Lin-Fa Wang, Laurent Renia, David Chien Lye, Barnaby E. Young
Publikováno v:
Trials. 23(1)
Background Over 2021, COVID-19 vaccination programs worldwide focused on raising population immunity through the primary COVID-19 vaccine series. In Singapore, two mRNA vaccines (BNT162b2 and mRNA-1273) and the inactivated vaccine CoronaVac are curre