Zobrazeno 1 - 10
of 116
pro vyhledávání: '"I Randen"'
Publikováno v:
Leukemia Research. 36:499-508
The roles of glycogen synthase kinase-3 (GSK-3) in cell survival and apoptosis are controversial. We examined the effect of a specific GSK-3 inhibitor (SB-415286) on the regulation of leukemic cells proliferation and apoptosis. SB-415286 (40 μM) ind
Publikováno v:
Annals of the New York Academy of Sciences. 764:440-449
We have compared RF from normal, immunized donors and RF derived from the synovial tissues of RA patients. We have found a difference in the preferential use of VL and VH gene families. In both conditions, RFs were found to have accumulated somatic m
Autor:
Reidun Hauge, Kirsten Sørensen, Anine B. Dahlberg, Mohammad Reza Mirlashari, I. Randen, Jens Kjeldsen-Kragh, Keith M. Thompson
Publikováno v:
Haematologica. 93:627-630
Alloimmunization is a common phenomenon after transfusion, with an estimated incidence of 0.5% increasing to 20-60% in chronically transfused patients. In recently transfused patients, serological typing can be hampered by mixed field agglutination.
Publikováno v:
Transfusion and Apheresis Science. 30:89-92
We have evaluated a flow cytometric screening method for identification of HPA la negative individuals, using a commercially available monoclonal anti-CD61 antibody specific for the HPA 1a allotype, and compared the method with an ELISA based method
Publikováno v:
Vox Sanguinis. 85:300-306
Background and Objectives The aim of the study was to perform fetal RHD genotyping in maternal plasma using a fluorescent polymerase chain reaction (PCR) technique. Duplex PCR, amplifying RHD and SRY in the same tube, was undertaken. The effect of va
Publikováno v:
Transfusion. 43:445-450
BACKGROUND: The probability for occurrence of neonatal alloimmune thrombocytopenic purpura (NAITP) depends largely on the frequency of each individual phenotype in various populations. In caucasians, antibodies to human platelet antigen (HPA)-1a are
Publikováno v:
The Journal of Immunology. 155:3630-3637
We have compared the variable regions of 14 new IgM rheumatoid factors (RFs), produced in healthy human immunized donors (HIDs) with RFs originating from patients with rheumatoid arthritis (RA) and monoclonal Ig RFs (paraproteins or M-components, MC)
Publikováno v:
Proceedings of the National Academy of Sciences. 91:12917-12921
Rheumatoid factor (RF) autoantibodies can be produced in healthy individuals after infections or immunizations and thus escape normal tolerization mechanisms. It has not been clear whether such autoantibodies can undergo somatic hypermutation and aff
Autor:
Jacob B. Natvig, Andzriej J. Soltys, Meinir G. Jones, Keith Thompson, Frank C. Hay, I. Randen, Angela Bond, J. S. Axford
Publikováno v:
Scandinavian Journal of Immunology. 40:135-143
There are several sites on IgG Fc that have been reported to be the epitopes for binding rheumatoid factors (RF). It is now established that there are alterations in the oligosaccharides on IgG from patients with rheumatoid arthritis and it has been
Autor:
V R Bonagura, S E Artandi, A Davidson, I Randen, N Agostino, K Thompson, J B Natvig, S L Morrison
Publikováno v:
The Journal of Immunology. 151:3840-3852
We have used chimeric IgG antibodies and their genetically engineered variants prepared by a combination of site-directed mutagenesis and exon exchange to define the structure(s) on IgG recognized by monoclonal rheumatoid factor (RF) autoantibodies f