Zobrazeno 1 - 10
of 10
pro vyhledávání: '"I R Oppliger"'
Publikováno v:
The Journal of Immunology. 149:3741-3752
In B cell precursors developing in fetal lymphopoietic tissue, the selection of VH, DH, and JH gene segments for initial H chain gene assembly is biased. The present study was designed to determine whether these biases persist in fully developed huma
Publikováno v:
The Journal of Experimental Medicine
The ability of human VH3 immunoglobulins (Ig) to bind to staphylococcal protein A (SPA) via their Fab region is analogous to the binding of bacterial superantigens to T cell receptors. The present report establishes the structural basis for the inter
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 149(11)
In B cell precursors developing in fetal lymphopoietic tissue, the selection of VH, DH, and JH gene segments for initial H chain gene assembly is biased. The present study was designed to determine whether these biases persist in fully developed huma
Autor:
Francis A. Nardella, I R Oppliger, Lars Björck, E. H. Sasso, G C Stone, M. Mannik, P. J. H. Johansson, Poul Christensen, J Sjöquist, A. K. Schröder
Publikováno v:
Scandinavian Journal of Rheumatology. 17:190-198
Work from our laboratories has shown that the major antigenic determinants for rheumatoid factors (RFs) are in the C gamma 2-C gamma 3 interface region of IgG in the same area that binds staphylococcal protein A (SPA). Furthermore, the Fc binding pro
Publikováno v:
The Journal of Immunology. 138:1391-1396
Considerable interest has focused on idiotypic cross-reactivity among antibody molecules. Cross-reactive idiotypes (Id) on monoclonal and polyclonal rheumatoid factors (RF) have been found frequently. Sufficient attention has not been directed, howev
Publikováno v:
The Journal of Immunology. 140:3114-3119
Experimental animal models and observations in humans suggest that levels of Id and auto-anti-Id fluctuate reciprocally after Ag stimulation. In human monoclonal B cell disorders, however, the co-existence of paraprotein Id and its auto-anti-Id has b
Autor:
Susan L. Jolly, Mark H. Wener, Peter A. Simkin, Giancarlo C. Stone, I R Oppliger, Bruce A. Wall, Augusto Aguirre, Regina Dwyer
Publikováno v:
Annals of internal medicine. 110(4)
An 82-year-old man and a 34-year-old woman developed subacute, obstructive, fatal vasculopathies characterized by extensive crystalline tissue deposits and monoclonal lambda light chain serum components. Cryocrystalglobulinemia was also present in on
Publikováno v:
The Journal of Experimental Medicine
The binding specificity of rheumatoid factors (RFs) to human Fc resembles that of some microbial Fc-binding proteins, suggesting conformational similarities in their Fc-binding regions. Using polyclonal chicken antibodies against SPA, we have detecte
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 138(5)
Considerable interest has focused on idiotypic cross-reactivity among antibody molecules. Cross-reactive idiotypes (Id) on monoclonal and polyclonal rheumatoid factors (RF) have been found frequently. Sufficient attention has not been directed, howev
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 140(9)
Experimental animal models and observations in humans suggest that levels of Id and auto-anti-Id fluctuate reciprocally after Ag stimulation. In human monoclonal B cell disorders, however, the co-existence of paraprotein Id and its auto-anti-Id has b