Zobrazeno 1 - 10
of 20
pro vyhledávání: '"I R, Wilding"'
Publikováno v:
Alimentary pharmacologytherapeutics. 17(9)
There is a growing clinical trend to increase the daily dose of mesalazine, which leads to significant compliance issues associated with multiple dosings of current preparations.To examine the gastrointestinal performance and systemic exposure of a 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24b00afdfee17dec999f49841d7c3b77
https://pubmed.ncbi.nlm.nih.gov/12752352
https://pubmed.ncbi.nlm.nih.gov/12752352
Publikováno v:
British journal of clinical pharmacology. 50(4)
The purpose of this in vivo human study was to assess the effect of altered gastric emptying and gastrointestinal motility on the absorption of metformin in healthy subjects.An open-label, three treatment, three period crossover study was conducted i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7c05ce530152d9866930ef4850ee566
https://pubmed.ncbi.nlm.nih.gov/11012555
https://pubmed.ncbi.nlm.nih.gov/11012555
Publikováno v:
Alimentary pharmacologytherapeutics. 14(2)
There is increasing interest in using higher dosages of mesalazine for the treatment of inflammatory bowel disease; however, with current mesalazine products this involves the use of 8-16 tablets per day.To evaluate the disposition, dispersion and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d1710025df2957944f9ee97f103b3dd
https://pubmed.ncbi.nlm.nih.gov/10651656
https://pubmed.ncbi.nlm.nih.gov/10651656
Autor:
I R, Wilding
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 8(3)
The Biopharmaceutics Classification System (BCS) has provided a mechanistic framework for understanding the concept of drug absorption in terms of permeability and solubility. Regulatory guidance for Immediate Release (IR) products incorporating the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::74cee735200e28acebf34835ad55e336
https://pubmed.ncbi.nlm.nih.gov/10379037
https://pubmed.ncbi.nlm.nih.gov/10379037
Publikováno v:
Pharmaceutical research. 16(1)
A human volunteer study was carried out to investigate whether activation of the ileal brake mechanism affects the transit of tablets through the small intestine.Oleic acid, which has previously been shown to activate the brake, was delivered to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e3cfce1bebab0f4758fcb935bfc713f
https://pubmed.ncbi.nlm.nih.gov/9950285
https://pubmed.ncbi.nlm.nih.gov/9950285
Publikováno v:
Pharmaceutical research. 15(7)
To evaluate if the cross-linking of gelatin affects in vivo capsule disintegration.Scintigraphic investigation in nine healthy volunteers to provide for a real time visualisation of capsule disintegration.The moderately stressed capsules failed the U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9aa318febe54a1515a54fa5b55319ca3
https://pubmed.ncbi.nlm.nih.gov/9688055
https://pubmed.ncbi.nlm.nih.gov/9688055
Publikováno v:
Pharmaceutical research. 15(3)
To evaluate mechanistically the effect of food on the absorption and gastrointestinal transit of the protease inhibitor saquinavir.Pharmacoscintigraphic investigation in eight healthy volunteers.Gastric emptying occurred rapidly in the fasted state w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b3d67c9422c5e794543203fcdfbf13f
https://pubmed.ncbi.nlm.nih.gov/9563071
https://pubmed.ncbi.nlm.nih.gov/9563071
Autor:
J, Brown, G, Hooper, C J, Kenyon, S, Haines, J, Burt, J M, Humphries, S P, Newman, S S, Davis, R A, Sparrow, I R, Wilding
Publikováno v:
Pharmaceutical research. 14(8)
In this paper we report on the first scintigraphic evaluation of vaginal dosage forms in post-menopausal women. To date, almost nothing is known about the in vivo performance of pharmaceutical formulations in the human vagina, which is a major defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1293ff91246d2fb15e2b5838672306a3
https://pubmed.ncbi.nlm.nih.gov/9279891
https://pubmed.ncbi.nlm.nih.gov/9279891
Autor:
D A, Adkin, C J, Kenyon, E I, Lerner, I, Landau, E, Strauss, D, Caron, A, Penhasi, A, Rubinstein, I R, Wilding
Publikováno v:
Pharmaceutical research. 14(1)
The aim of the present study was to provide "proof of concept" data in man for novel polysaccharide preparations designed for colonic drug delivery using gamma scintigraphy.Two placebo calcium pectinate matrix tablet formulations were studied: one co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a987c59216c2faf857a48a1e167369f6
https://pubmed.ncbi.nlm.nih.gov/9034229
https://pubmed.ncbi.nlm.nih.gov/9034229
Autor:
D A, Adkin, P, Gowland, R C, Spiller, A, Freeman, J, Hykin, B, Issa, P D, Huckle, I R, Wilding
Publikováno v:
Pharmaceutical research. 12(8)
Assessment of fluid volumes and flow through the small intestine has in the past only been possible by means of invasive intubation studies on human volunteers. Intubation very likely disturbs gut motility and stimulates secretion.The aim of this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5f99cbac76cfa1c064c331988dab19a
https://pubmed.ncbi.nlm.nih.gov/7494824
https://pubmed.ncbi.nlm.nih.gov/7494824