Zobrazeno 1 - 10
of 35
pro vyhledávání: '"I R, Patel"'
Autor:
Mary B. Goldring, Christine Cipolletta, I R Patel, Pil Kang, Mandar Dave, Ashok R. Amin, Steven B. Abramson, Mukundan Attur
Publikováno v:
Journal of Biological Chemistry. 275:40307-40315
Interleukin 1 (IL-1), produced by both synovial cells and chondrocytes, plays a pivotal role in the pathogenesis of cartilage destruction in osteoarthritis (OA). We examined the specific expression and function of IL-1 receptor family-related genes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c905aa50f1cf328508e4cba47d56bfe
https://doi.org/10.1074/jbc.m002721200
https://doi.org/10.1074/jbc.m002721200
Publikováno v:
The Journal of Immunology. 164:2684-2691
Osteoarthritis-affected cartilage exhibits enhanced expression of fibronectin (FN) and osteopontin (OPN) mRNA in differential display and bioinformatics screen. Functional genomic analysis shows that the engagement of the integrin receptors α5β1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7b7c850f5961d24822e49e0be57dec6
https://doi.org/10.4049/jimmunol.164.5.2684
https://doi.org/10.4049/jimmunol.164.5.2684
Autor:
Sue H. Kadwell, G B Wisely, Derril H. Willard, Zajac-Thompson I, Christine R. Hoffman, Michael A. Luther, G. Tian, I R Patel, William C. Clay, William D. Holmes, Jeffrey S. Wiseman, Warren J. Rocque
Publikováno v:
Biochemistry. 36:14250-14261
The interactions between (R)-rolipram and purified human recombinant low-Km, cAMP-specific phosphodiesterase (HSPDE4B2B) constructs were investigated using biochemical, kinetic, and biophysical approaches. The full-length protein (amino acids 1-564)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64705e7668ed56456b68255c06627014
https://doi.org/10.1021/bi971112e
https://doi.org/10.1021/bi971112e
Autor:
Michael A. Luther, Laurie K. Overton, Christine R. Hoffman, Ittoop O, Warren J. Rocque, I R Patel, Derril H. Willard, G B Wisely, Dougherty Rw, William D. Holmes
Publikováno v:
Protein Expression and Purification. 9:191-202
We have overexpressed in a baculovirus expression system, and purified to > 95% homogeneity, milligram quantities of a human recombinant rolipram-sensitive cAMP phosphodiesterase, HSPDE4B2B (amino acid residues 81-564). The protein expression levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0cbe1b49484c5d683c3f20c48f3451b
https://doi.org/10.1006/prep.1996.0683
https://doi.org/10.1006/prep.1996.0683
Phosphorylation of a cAMP-specific phosphodiesterase (HSPDE4B2B) by mitogen-activated protein kinase
Autor:
William D. Holmes, James M. Lenhard, Michael A. Luther, I R Patel, Lawrence L. Hamacher, Christine R. Hoffman, Daniel B. Kassel, Warren J. Rocque
Publikováno v:
Biochemical Journal. 316:751-758
A cAMP-specific phosphodiesterase, HSPDE4B2B, was found to be phosphorylated when expressed in Sf 9 cells or yeast. Deletion of amino acids 81–151 and 529–564 had no effect on the phosphorylation of HSPDE4B2B. Mass spectrometric analysis of purif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6181dcc41b469f0975b1776feea61cd
https://doi.org/10.1042/bj3160751
https://doi.org/10.1042/bj3160751
Autor:
Marcia L. Moss, I R Patel, A. G. Peranteau, G. Tian, Stephen V. Frye, Sue H. Kadwell, J. D. Stuart, L. K. Overton, Petr Kuzmic, T. A. Kost
Publikováno v:
Scopus-Elsevier
We have discovered that 17β-[N,N-(diethyl)carbamoyl]-6-azaandrost-4-en-3-one is a time-dependent inhibitor of type II 5α-reductase, as is the drug finasteride. Unlike finasteride, the 6-aza-steroid is not a time-dependent inhibitor of type I 5α-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c892d263df65a95906b65268cca172d
https://doi.org/10.1021/bi952472+
https://doi.org/10.1021/bi952472+
Autor:
Michael B. Zemel, Sue H. Kadwell, Edward J. Michaud, J. H. Kim, I R Patel, Richard P. Woychik, William O. Wilkison
Publikováno v:
Proceedings of the National Academy of Sciences. 92:4733-4737
Several dominant mutations at the agouti locus in the mouse cause a syndrome of marked obesity, hyperinsulinemia, and insulin resistance. Although it is known that the agouti gene is expressed in an ectopic manner in these mutants, the precise mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07c27ac162131681524f97d84a2c94d4
https://doi.org/10.1073/pnas.92.11.4733
https://doi.org/10.1073/pnas.92.11.4733
Autor:
Sue H. Kadwell, Domanico Pl, J. D. Stuart, G. Tian, Marcia L. Moss, T. A. Kost, L. K. Overton, Robert A. Mook, I R Patel, H. N. Bramson
Publikováno v:
Biochemistry. 33:2291-2296
17 beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androstan-1-en-3-one (finasteride), which has been approved for treatment of benign prostatic hyperplasia, is shown here to be a slow time-dependent inhibitor of human steroid 5 alpha-reductase isozyme 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734895a64604489e39df0587cc4ba7af
https://doi.org/10.1021/bi00174a041
https://doi.org/10.1021/bi00174a041
Publikováno v:
Journal of Virology. 65:3276-3283
The CD4 molecule, a glycoprotein expressed primarily on the cell surface of specific T lymphocytes, is thought to function in T-cell antigen recognition and activation. In addition, CD4 serves as a receptor for human immunodeficiency virus type 1 (HI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f895882305b5cc62b3978b034919d90
https://doi.org/10.1128/jvi.65.6.3276-3283.1991
https://doi.org/10.1128/jvi.65.6.3276-3283.1991
