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The Interaction of Herpes Simplex Type 1 Virus Origin-binding Protein (UL9 Protein) with Box I, the High Affinity Element of the Viral Origin of DNA Replication

Autor: I. R. Lehman, Sam S. K. Lee

Publikováno v: Journal of Biological Chemistry. 274:18613-18617

The herpes simplex type 1 (HSV-1) origin binding protein, the UL9 protein, exists in solution as a homodimer of 94-kDa monomers. It binds to Box I, the high affinity element of the HSV-1 origin, Oris, as a dimer. The UL9 protein also binds the HSV-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0708151efa72936ed49482b1f7d089b9
https://doi.org/10.1074/jbc.274.26.18613

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The Herpes Simplex Virus Type 1 Helicase-primase

Autor: I. R. Lehman, Maria Falkenberg, Per Elias

Publikováno v: Journal of Biological Chemistry. 273:32154-32157

The rate of unwinding of duplex DNA by the herpes simplex virus type 1 (HSV-1)-encoded helicase-primase (primosome) was determined by measuring the rate of appearance of single strands from a circular duplex DNA containing a 40-nucleotide 5' single-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14a29e65a9a2a85f8a806919397d5c29
https://doi.org/10.1074/jbc.273.48.32154

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The herpes simplex virus type 1 origin-binding protein carries out origin specific DNA unwinding and forms stem-loop structures

Autor: Alexander M. Makhov, Jack D. Griffith, P E Boehmer, I R Lehman

Publikováno v: The EMBO Journal. 15:1742-1750

The UL9 protein of herpes simplex virus type 1 (HSV-1) binds specifically to the HSV-1 oriS and oriL origins of replication, and is a DNA helicase and DNA-dependent NTPase. In this study electron microscopy was used to investigate the binding of UL9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc0451ed0103d20f7d83d64edc58fe2f
https://doi.org/10.1002/j.1460-2075.1996.tb00520.x

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Inhibition of Herpes Simplex Virus Type 1 Helicase-Primase by (Dichloroanilino)purines and -pyrimidines

Autor: Joseph Gambino, Maria M. Medveczky, J. J. Crute, Peter G. Medveczky, George E. Wright, I. R. Lehman, Te-Fang Yang, Monroe J, Naseema N. Khan, C. Mulder

Publikováno v: Journal of Medicinal Chemistry. 38:1820-1825

Herpes simplex virus type 1 (HSV1) encodes a heterotrimeric helicase-primase comprised of the products of three of the seven DNA replication-specific genes. Several dihalo-substituted derivatives of N 2-phenylguanines and 2-anilinoadenines weakly inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989ae3923f810bcdeb9f6cab0e5f6b8c
https://doi.org/10.1021/jm00010a027

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Herpes simplex virus type 1 DNA replication is specifically required for high-frequency homologous recombination between repeated sequences

Autor: I. R. Lehman, Rebecca Ellis Dutch, V Bianchi

Publikováno v: Journal of Virology. 69:3084-3089

Using an assay for recombination that measures deletion of a beta-galactosidase gene positioned between two directly repeated 350-bp sequences in plasmids transiently maintained in COS cells, we have found that replication from a simian virus 40 orig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55c9d1a3640ec0662f18dc124abbbed
https://doi.org/10.1128/jvi.69.5.3084-3089.1995

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Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo

Autor: Paul E. Boehmer, Nigel D. Stow, I. R. Lehman, Marianne C. Craigie

Publikováno v: Journal of Biological Chemistry. 269:29329-29334

The herpes simplex virus type 1 (HSV-1) origin binding protein (UL9 protein) interacts specifically with the HSV-1 encoded single strand DNA-binding protein ICP8 (Boehmer, P.E. and Lehman, I.R. (1994) Proc. Natl. Acad. Sci. U.S.A. 90, 8444-8448). A U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9180232ef610a23899874b2033079291
https://doi.org/10.1016/s0021-9258(19)62048-x

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Rolling circle DNA replication in vitro by a complex of herpes simplex virus type 1-encoded enzymes

Autor: I. R. Lehman, Rami Skaliter

Publikováno v: Proceedings of the National Academy of Sciences. 91:10665-10669

Extracts of insect cells infected with baculoviruses recombinant for the herpes simplex virus 1 (HSV-1)-encoded enzymes that are required for its replication can promote the rolling circle replication of circular plasmid templates. Replication is ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8b3687ab690b8d58cae9260b5a2709
https://doi.org/10.1073/pnas.91.22.10665

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