Zobrazeno 1 - 10
of 77
pro vyhledávání: '"I P M Tomlinson"'
Autor:
L. Lemler, K. Donnelly, I. P. M. Tomlinson, M. Timofeeva, E. Theodoratou, C. Fernández Rozadilla, J. Fernandez-Tajes, Graeme Grimes, Susan M. Farrington, M. G. Dunlop
IntroductionColorectal cancer (CRC) is the second most common cause of cancer death globally. Genome-wide association studies have established that cancer risk mediated through common genetic variants can be linked to variation in gene expression. Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::104950c476294dcdbb90e4103ce0fbc0
https://doi.org/10.1101/2022.11.21.515057
https://doi.org/10.1101/2022.11.21.515057
Autor:
I. P. M. Tomlinson, Matthew G. Wallis, G. M. Lawrence, D. Dodwell, Graham Ball, S. Cheung, O Kearins, Karen Clements, Elinor J. Sawyer, Anthony J. Maxwell, James D. Thomas, A. Thompson, Sarah E Pinder, Andrew M. Hanby
Publikováno v:
Cancer Research. 78:P4-15
Key words: DCIS, radiotherapy, endocrine therapy, survival, surgical margins Background: The benefits and risks of breast screening remain controversial, with particular concern that ductal carcinoma in situ (DCIS) may be over-diagnosed and over-trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83f46a6069d7a8e26967460c14b1f848
https://doi.org/10.1158/1538-7445.sabcs17-p4-15-02
https://doi.org/10.1158/1538-7445.sabcs17-p4-15-02
Autor:
J. J. Briere, Patrick J. Pollard, John A. McGrath, Pierre Rustin, Tim Hunt, Noel C. Wortham, I. P. M. Tomlinson, J Barwell, John R. Griffiths, Richard Poulsom, Michael Gleeson, Yuen-Li Chung, Stuart James Moat, Shirley Hodgson, S. J. Heales, Ella Barclay, M. Mitchell, Iain P. Hargreaves, Simon E. Olpin, N. A. Alam, A. Dalgleish
The nuclear-encoded Krebs cycle enzymes, fumarate hydratase (FH) and succinate dehydrogenase (SDHB, -C and -D), act as tumour suppressors. Germline mutations in FH predispose individuals to leiomyomas and renal cell cancer (HLRCC), whereas mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b9dc50ebc4c834eaaac43194c8a5b9
https://ora.ox.ac.uk/objects/uuid:de46a702-0f5a-4b29-b48b-1de3034c087a
https://ora.ox.ac.uk/objects/uuid:de46a702-0f5a-4b29-b48b-1de3034c087a
Autor:
A S Lee, L Bromley, James O'd. McGee, J E Strickland, M F Evans, J Morton, I. P. M. Tomlinson
AIMS--Chromosome 11q23 seems to be a site of frequent mutation in cancer. It also contains loci such as ataxia telangiectasia with possible importance in the pathogenesis of breast tumours. The short arm of chromosome 11 has been studied extensively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a18c56d510c20c4d82ad7c7d8e9e3d9
https://ora.ox.ac.uk/objects/uuid:aeab333a-83c4-4a03-94de-28df96596aa4
https://ora.ox.ac.uk/objects/uuid:aeab333a-83c4-4a03-94de-28df96596aa4
Autor:
I. P. M. Tomlinson, Gabriela Moeslein, Virpi Launonen, T Vogel, Mecklin Jp, F W M de Rooji, Kristiina Aittomäki, Anne Marie Westerman, James P. Robinson, Emmanouil Volikos, Andrew Silver, Lauri A. Aaltonen, Helinä Järvinen
Publikováno v:
Journal of Medical Genetics, 43(5). BMJ Publishing Group
Background: LKB1/STK11 germline mutations cause Peutz-Jeghers syndrome (PJS). The existence of a second PJS locus is controversial, the evidence in its favour being families unlinked to LKB1 and the low frequency of LKB1 mutations found using convent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745995d7e2c455e0bd122fa6643942b0
https://ora.ox.ac.uk/objects/uuid:b20eef3c-afa0-42a9-a797-b73ad7f1124f
https://ora.ox.ac.uk/objects/uuid:b20eef3c-afa0-42a9-a797-b73ad7f1124f
Loss of heterozygosity (LOH, allele loss) occurs frequently on the long arm of chromosome 11 in breast cancer. Seventy-one paired tumour/normal DNA samples from breast cancer patients under 50 years old were studied for allele loss at four microsatel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6127a487b9f207015cbf0ab82cf4eb58
https://ora.ox.ac.uk/objects/uuid:c8f488fd-cf8f-4e19-baab-7ed8e8b0cd6e
https://ora.ox.ac.uk/objects/uuid:c8f488fd-cf8f-4e19-baab-7ed8e8b0cd6e
Autor:
I. P. M. Tomlinson, L Tinworth, J Barwell, S Rose, Nayanta Sodha, Shirley Hodgson, S. J. Payne, H Brinkman, C Langman, Samantha Fisher, L Brooks, A Rowan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1054f39e4e016c17757aa9b6aacd6cf3
https://ora.ox.ac.uk/objects/uuid:e9a5884f-75ee-4424-a26b-83205c0f0172
https://ora.ox.ac.uk/objects/uuid:e9a5884f-75ee-4424-a26b-83205c0f0172
Autor:
I. P. M. Tomlinson, Ian M. Frayling, James M. Buchanan, Jenny C. Taylor, Irene Papanicolas, Sarah Wordsworth
Background: Somatic mutations are important determinants of cancer behaviour and response to therapy. However, molecular testing in this context has a relatively low profile within the clinical community, despite publicity surrounding targeted therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9787e014e57c55d2d7fd991cdeff04f
https://doi.org/10.1136/jcp.2007.054510
https://doi.org/10.1136/jcp.2007.054510
Autor:
K Neale, D. Davies, Karl Heinimann, C. A. Simpson, Patricia Gorman, Robin K. S. Phillips, Oliver M. Sieber, H. Lamlum, Walter F. Bodmer, Rebecca Roylance, Michael Crabtree, I. P. M. Tomlinson, Shirley Hodgson
In vitro data show that the adenomatous polyposis coli (APC) protein associates with the mitotic spindle and that mouse embryonic stem cells with biallelic Apc mutations are karyotypically unstable. These findings led to suggestions that APC acts in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adf013e9910196f00fc54c839a4b07d
https://ora.ox.ac.uk/objects/uuid:10baf638-5939-44bd-8140-1d671edb3ba8
https://ora.ox.ac.uk/objects/uuid:10baf638-5939-44bd-8140-1d671edb3ba8
Autor:
Nicholas A. Wright, Marco Novelli, I. P. M. Tomlinson, I. C. Talbot, G Elia, Shirley Hodgson, Jill Williamson, Walter F. Bodmer
Publikováno v:
Scopus-Elsevier
It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758675fefe3975911165f210b347b960
https://doi.org/10.1126/science.272.5265.1187
https://doi.org/10.1126/science.272.5265.1187