Zobrazeno 1 - 10
of 50
pro vyhledávání: '"I P, Gileva"'
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 24, Iss 3, Pp 239-243 (2020)
Tumor necrosis factor (TNF) is one among the key cytokines that mediate the immune system to protect humans against viral infections. Throughout evolution, anthropogenic Variola virus (VARV) has developed effective mechanisms to overcome human defens
Externí odkaz:
https://doaj.org/article/7f73e38844824e1c9f6c57c1d0208075
Autor:
L. V. Sakhno, O. Yu. Leplina, Zh. M. Raspay, M. A. Tikhonova, E. V. Kurganova, I. P. Gileva, S. D. Nikonov, O. A. Zhdanov, A. A. Ostanin, E. R. Chernykh
Publikováno v:
Медицинская иммунология, Vol 10, Iss 2-3, Pp 151-158 (2014)
Abstract. Some functional properties of IFNα-induced dendritic cells (DCs) from the patients with pulmonary tuberculosis (PT) were under study. It was revealed that production of IFNγ and IFNα by DCs of the patients was decreased, but TNFα produc
Externí odkaz:
https://doaj.org/article/439743640c8e490cadd03ac88cadc002
Publikováno v:
Медицинская иммунология, Vol 12, Iss 4-5, Pp 297-304 (2014)
We studied the effect of a recombinant murine TNF (rmTNF) and TNF-binding protein of Variola virus (VARV-CrmB) upon colony-forming ability of bone marrow cells (BMC) from Balb/c mice. BMC were grown in semisolid methylcellulose medium supplemented wi
Externí odkaz:
https://doaj.org/article/1b95e25546ea4e2bae5fd5b7067dbe7b
Autor:
I. A. Orlovskaya, D. D. Tsyrendorzhiev, L. B. Toporkova, V. V. Kurilin, Y. A. Lopatnikova, E. A. Vyazovaya, I. P. Gileva, S. N. Schelkunov, S. V. Sennikov
Publikováno v:
Медицинская иммунология, Vol 14, Iss 1-2, Pp 33-42 (2014)
Abstract. This review presents a summary of our data concerning in vivo and in vitro effects of recombinant TNF-binding protein from variola virus (VARVCrmB) upon TNF-induced functional changes of human and murine cells. VARV-CrmB protein blocks TNF-
Externí odkaz:
https://doaj.org/article/d14b70b0f2b74107a38287519f059cc7
Autor:
D. D. Tsyrendorzhiev, S. V. Sennikov, I. A. Orlovskaya, I. P. Gileva, I. A. Ryazankin, L. B. Toporkova, V. V. Kurilin, Yu. A. Lopatnikova, A. A. Grydina, S. N. Schelkunov
Publikováno v:
Медицинская иммунология, Vol 15, Iss 6, Pp 513-524 (2014)
Abstract. This paper presents the results of the research on the effectiveness of recombinant TNF-binding protein of variola virus (VARV-CrmB) in a model of collagen-induced arthritis (CIA) in mice (CBAxC57Bl6) F1. The introduction of VARV-CrmB and p
Externí odkaz:
https://doaj.org/article/6bd0fc6fdfea43959facbd28c55ebf8b
Autor:
Rustem D. Kasymov, Evgeniia A. Diatlova, Grigoriy A. Stepanov, Grigory V. Mechetin, Ghermes G. Chilov, Anna V. Yudkina, I. P. Gileva, Dmitry O. Zharkov, Sergei N. Shchelkunov, Inga R. Grin, Alexandra A. Denisova
Publikováno v:
Molecules
Molecules, Vol 26, Iss 6668, p 6668 (2021)
Volume 26
Issue 21
Molecules, Vol 26, Iss 6668, p 6668 (2021)
Volume 26
Issue 21
Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The activity of Family 1 uracil–DNA glycosylase (UNG) activity limits the effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d097b622de0f7364c5719d8a0d184eab
http://europepmc.org/articles/PMC8587785
http://europepmc.org/articles/PMC8587785
Autor:
Galina V. Kochneva, I. P. Gileva, Т.А. Tereshchenko, A. A. Grazhdantseva, Ya.S. Gogina, Е.А. Volosnikova, Lebedev Lr, E.D. Danilenko
Publikováno v:
Biotekhnologiya. :68-73
A suggested method for obtaining recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) includes the accumulation of the producer strain biomass enriched with the target product up to 30% of total protein content, its isolation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee3a2fb3d4ed6fc1f584ae3932c1133a
https://doi.org/10.21519/0234-2758-2019-35-3-68-73
https://doi.org/10.21519/0234-2758-2019-35-3-68-73
Autor:
Ludmila B. Toporkova, I. P. Gileva, Irina A. Orlovskaya, Sergei N. Shchelkunov, Elena A. Viazovaia
Publikováno v:
Current Pharmaceutical Biotechnology. 19:910-916
Background Large DNA poxviruses encode a diverse family of secreted proteins that modulate host inflammatory and antiviral responses, in particular by inhibiting one of the key players of the mammalian immune system, the tumor necrosis factor (TNF).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76525bfc59bd78560bce8ec234013ced
https://doi.org/10.2174/1389201019666181029111011
https://doi.org/10.2174/1389201019666181029111011
Autor:
V. A. Rikhter, G. V. Kochneva, Elena V. Kuligina, A. V. Tkacheva, G. F. Sivolobova, I. P. Gileva, A. A. Grazhdantseva
Publikováno v:
Applied Biochemistry and Microbiology. 52:685-691
The recombinant vaccinia virus strain VV-GMCSF-S1/3, which contains an insertion of full-length DNA copy of messenger RNA of human granulocyte-macrophage colony-stimulating factor (GM-CSF) in the structural part of the viral thymidine kinase gene, wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68635ad7e9ff6f52d7adb08e1d9378e6
https://doi.org/10.1134/s0003683816070036
https://doi.org/10.1134/s0003683816070036
Autor:
Elena A. Viazovaia, Irina A. Orlovskaya, Dondok D. Tsyrendorzhiev, I. P. Gileva, Sergei N. Shchelkunov, Ludmila B. Toporkova
Publikováno v:
Current Pharmaceutical Biotechnology. 16:72-76
VARV-CrmB is a TNF binding protein of variola virus. VARV-CrmB protein was previously shown to be active as a TNF-antagonist in a number of in vivo and in vitro models. Here we investigated the epicutaneous effect of recombinant VARV-CrmB protein usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc2841a950ca238de4300b5dd45128e
https://doi.org/10.2174/1389201015666141126114945
https://doi.org/10.2174/1389201015666141126114945