Zobrazeno 1 - 10
of 15
pro vyhledávání: '"I N, White"'
Autor:
I N, White
Publikováno v:
Pharmaceutical research. 1(4)
Compounds containing a terminal carbon-carbon triple bond, ranging in structure from the 17α-ethynyl substituted contraceptive steroids to acetylene gas, when administered to rats cause a selective and rapid time dependent loss of up to 50% of hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81401b0393509ff1af85cf4b350e950b
https://pubmed.ncbi.nlm.nih.gov/24277281
https://pubmed.ncbi.nlm.nih.gov/24277281
Autor:
J, Martin, I N, White
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 10
Morphologically, the lung is a complex organ containing over 40 different cell types (1). Although species and strain dependent, in the Fischer rat, the most common cell types include: endothelial, 33%; Type I, 6.5%; Type II, 12%; macrophages, 8%; ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::89507dc144956ed5b361499503ba4c3a
https://pubmed.ncbi.nlm.nih.gov/23150328
https://pubmed.ncbi.nlm.nih.gov/23150328
Autor:
I N, White, N, Razvi, A H, Gibbs, A M, Davies, M, Manno, C, Zaccaro, F, De Matteis, A, Pähler, W, Dekant
Publikováno v:
Toxicology letters. 124(1-3)
In this study, the metabolic activation of 2,2-dichloro-1,1,1-trifluoroethane (hydrochlorofluorocarbons-123, HCFC-123), halothane or 1,1-dichloro-1-fluoroethane (HCFC-141b) was compared to that of perchloroethylene, using lymphoblastoma derived cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc19a8612cc96724f57a6738bc0d8847
https://pubmed.ncbi.nlm.nih.gov/11684365
https://pubmed.ncbi.nlm.nih.gov/11684365
Autor:
L L, Smith, I N, White
Publikováno v:
Oncology (Williston Park, N.Y.). 12(3 Suppl 5)
Tamoxifen is by far the most clinically tested antiestrogenic drug currently used as adjuvant therapy for breast cancer and it continues to provide considerable benefit in this setting. The balance from clinical trials indicates a strong association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8aa6c9efe3fb1b874e287e58c6d23b11
https://pubmed.ncbi.nlm.nih.gov/9556786
https://pubmed.ncbi.nlm.nih.gov/9556786
Publikováno v:
Cancer research. 57(7)
Tamoxifen, a rat liver carcinogen, was administered to female lambda/lacI transgenic rats at a dose of 20 mg/kg body weight by gavage for 6 weeks, and the animals were sacrificed 2 weeks later. Tamoxifen induced liver DNA adducts and caused a signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3ad701523482d20653a557c67083528
https://pubmed.ncbi.nlm.nih.gov/9102215
https://pubmed.ncbi.nlm.nih.gov/9102215
Publikováno v:
Progress in clinical and biological research. 396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::595a86a4c7ec7913da5b89190a230e7f
https://pubmed.ncbi.nlm.nih.gov/9108603
https://pubmed.ncbi.nlm.nih.gov/9108603
Autor:
R, Davies, V I, Oreffo, S, Bayliss, P A, Dinh, K S, Lilley, I N, White, L L, Smith, J A, Styles
Publikováno v:
Environmental and molecular mutagenesis. 28(4)
Tamoxifen, an important drug in breast cancer treatment, causes liver cancer in rats. The standard range of in vitro tests have failed to show that it causes DNA damage, but 32P-postlabelling and DNA-binding studies have shown that tamoxifen forms DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7cc95c26a0d908021a9a094a122b14c7
https://pubmed.ncbi.nlm.nih.gov/8991074
https://pubmed.ncbi.nlm.nih.gov/8991074
Autor:
P, Carthew, E A, Martin, I N, White, F, De Matteis, R E, Edwards, B M, Dorman, R T, Heydon, L L, Smith
Publikováno v:
Cancer research. 55(3)
Tamoxifen administered in the diet (420 ppm) to Wistar rats (TOX:P) for only 3 months caused cumulative hepatic DNA damage as assessed by 32P-postlabeling, consistent with the proposal that tamoxifen is a genotoxic carcinogen in this species. Promoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab0c62363202655c252c5c2b84086f93
https://pubmed.ncbi.nlm.nih.gov/7834623
https://pubmed.ncbi.nlm.nih.gov/7834623
Publikováno v:
European journal of pharmacology. 248(1)
C57Bl/10 mice were given halothane (10 mmol/kg, intraperitoneally) and microsomal proteins were analysed for the presence of trifluoroacetylated (TFA) neoantigens by SDS-gel electrophoresis followed by immunoblotting using a polyclonal anti-TFA antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe25414e2e1fae9085a163b32b7770eb
https://pubmed.ncbi.nlm.nih.gov/8339751
https://pubmed.ncbi.nlm.nih.gov/8339751
Autor:
F. De Matteis, David H. Phillips, A Hewer, I N White, Adrian M. Davies, Lewis L. Smith, Stanley Venitt, Christopher Crofton-Sleigh
Publikováno v:
Carcinogenesis. 13(12)
Chronic administration of tamoxifen to female rats causes hepatocellular carcinomas. We have investigated damage to liver DNA caused by the administration of tamoxifen to female Fischer F344/N rats or C57B1/6 or DBA/2 mice using 32P-postlabelling. Fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26edbbf09981f57b6a5fb715b1b6b65
https://pubmed.ncbi.nlm.nih.gov/1473224
https://pubmed.ncbi.nlm.nih.gov/1473224