Výsledky vyhledávání - "I N, Mbawuike"

Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-γ producing CD8+ T cells

Autor: Jerry R. McGhee, I N Mbawuike, S Di Fabio, Hiroshi Kiyono, R B Couch, K Fujihashi

Publikováno v: International Immunology. 6:11-19

To study virus-specific cytotoxic T lymphocyte (CTL) activity at the single cell level, an IFN-gamma specific ELISPOT assay was adapted to elucidate the frequency of influenza-specific CTLs together with a standard cytotoxic 51Cr-release assay. Perip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a187b3bc02de8a4a84e96ac9372e09d1
https://doi.org/10.1093/intimm/6.1.11

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Apoptosis and reduced influenza A virus specific CD8+ T cells in aging mice

Autor: P Tebebi, I N Mbawuike, X Gilmore, Ying Wang, Keyi Xu, Yongxin Zhang, M Chen

Publikováno v: Cell death and differentiation. 9(6)

Some studies have reported increased apoptosis in CD8(+) T cells from aged mice. We previously demonstrated diminished virus-specific CD8(+) cytotoxic T lymphocyte (CTL) activity in aged mice in comparison to young mice. The present study investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd333d082bd144cb1c6c2a9cd32b33aa
https://pubmed.ncbi.nlm.nih.gov/12032674

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Mucosal immunity to influenza without IgA: an IgA knockout mouse model

Autor: I N, Mbawuike, S, Pacheco, C L, Acuna, K C, Switzer, Y, Zhang, G R, Harriman

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(5)

IgA knockout mice (IgA-/-) were generated by gene targeting and were used to determine the role of IgA in protection against mucosal infection by influenza and the value of immunization for preferential induction of secretory IgA. Aerosol challenge o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e425ca42c19168876d9986fd17f4bc4
https://pubmed.ncbi.nlm.nih.gov/10072492

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Cytokines and impaired CD8+ CTL activity among elderly persons and the enhancing effect of IL-12

Autor: I N, Mbawuike, C L, Acuna, K C, Walz, R L, Atmar, S B, Greenberg, R B, Couch

Publikováno v: Mechanisms of ageing and development. 94(1-3)

We have previously demonstrated that about 70% of elderly persons exhibit deficient cytotoxic T lymphocyte (CD8+ CTL) responses against influenza viruses when compared to young persons. Since IFN-gamma, a Th1 cytokine and IL-4, a Th2 cytokine, stimul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0f7c2716200719ea60358bd8191a71b
https://pubmed.ncbi.nlm.nih.gov/9147358

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Cytotoxic T lymphocyte responses of infants after natural infection or immunization with live cold-recombinant or inactivated influenza A virus vaccine

Autor: I N, Mbawuike, P A, Piedra, T R, Cate, R B, Couch

Publikováno v: Journal of medical virology. 50(2)

The cytotoxic T lymphocyte (CTL) response of infants after immunization with either inactivated trivalent subvirion vaccine (TIV) or bivalent attenuated cold-recombinant (CR) vaccine or occurrence of natural influenza virus infection were compared in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e318b9172fe2c952086197a7700b26ee
https://pubmed.ncbi.nlm.nih.gov/8915874

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Enhanced recovery of murine alveolar macrophages: morphological and functional characteristics following intravenous injection of heat-killed Mycobacterium bovis BCG

Autor: Herbert B. Herscowitz, J E Luhr, I N Mbawuike

Publikováno v: Infection and Immunity. 51:483-489

The kinetics of induction of the bronchoalveolar cell population (i.e., alveolar macrophages [AM], lymphocytes, and polymorphonuclear leukocytes) was studied in mice inoculated intravenously with heat-killed Mycobacterium bovis BCG. Injection of BCG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca4957d741beaea35807a8b32fb88b8
https://doi.org/10.1128/iai.51.2.483-489.1986

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Role of activation in alveolar macrophage-mediated suppression of the plaque-forming cell response

Autor: H B Herscowitz, I N Mbawuike

Publikováno v: Infection and Immunity. 56:577-581

Alveolar macrophages (AM) are highly suppressive of the in vitro plaque-forming cell (PFC) response of spleen cells obtained from mice primed with sheep erythrocytes. Comparison of macrophage populations obtained from disparate anatomical sites revea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3fa65f39e7d90a6c77adb2f71224cd
https://doi.org/10.1128/iai.56.3.577-581.1988

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Relationship between ineffective antigen presentation by murine alveolar macrophages and their immunosuppressive function

Autor: I N, Mbawuike, H B, Herscowitz

Publikováno v: Immunology. 64(1)

Murine alveolar macrophages (AM) have been shown to be inefficient at providing accessory function for initiation of the in vitro plaque-forming cell (PFC) response. In the present study AM, which were obtained either from untreated mice (resident AM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2aee0bc9865af897e519c505189e7779
https://pubmed.ncbi.nlm.nih.gov/3133308

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