An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma

Autor: Stephanie M. Casillo, Taylor A. Gatesman, Akanksha Chilukuri, Srinidhi Varadharajan, Brenden J. Johnson, Daniel R. David Premkumar, Esther P. Jane, Tritan J. Plute, Robert F. Koncar, Ann-Catherine J. Stanton, Carlos A.O. Biagi-Junior, Callie S. Barber, Matthew E. Halbert, Brian J. Golbourn, Katharine Halligan, Andrea F. Cruz, Neveen M. Mansi, Allison Cheney, Steven J. Mullett, Clinton Van’t Land, Jennifer L. Perez, Max I. Myers, Nishant Agrawal, Joshua J. Michel, Yue-Fang Chang, Olena M. Vaske, Antony MichaelRaj, Frank S. Lieberman, James Felker, Sruti Shiva, Kelsey C. Bertrand, Nduka Amankulor, Costas G. Hadjipanayis, Kalil G. Abdullah, Pascal O. Zinn, Robert M. Friedlander, Taylor J. Abel, Javad Nazarian, Sriram Venneti, Mariella G. Filbin, Stacy L. Gelhaus, Stephen C. Mack, Ian F. Pollack, Sameer Agnihotri

Publikováno v: Cell Reports, Vol 43, Iss 1, Pp 113557- (2024)

Summary: Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced by the hallmark histone mutation H3K27M, which results in aberrantly permissive activation of oncogenic signaling pathways. Previous stu

Externí odkaz: https://doaj.org/article/a1cfb726d57743518bf0449e2947643f

First High‐Speed Video Camera Observations of a Lightning Flash Associated With a Downward Terrestrial Gamma‐Ray Flash

Autor: R. U. Abbasi, M. M. F. Saba, J. W. Belz, P. R. Krehbiel, W. Rison, N. Kieu, D. R. daSilva, M. A. Stanley, Dan Rodeheffer, J. Remington, J. Mazich, R. LeVon, K. Smout, A. Petrizze, T. Abu‐Zayyad, M. Allen, R. Arimura, E. Barcikowski, D. R. Bergman, S. A. Blake, I. Buckland, B. G. Cheon, M. Chikawa, T. Fujii, K. Fujisue, K. Fujita, R. Fujiwara, M. Fukushima, G. Furlich, N. Globus, R. Gonzalez, W. Hanlon, N. Hayashida, H. He, K. Hibino, R. Higuchi, K. Honda, D. Ikeda, N. Inoue, T. Ishii, H. Ito, D. Ivanov, H. Iwakura, A. Iwasaki, H. M. Jeong, S. Jeong, C. C. H. Jui, K. Kadota, F. Kakimoto, O. Kalashev, K. Kasahara, S. Kasami, S. Kawakami, K. Kawata, I. Kharuk, E. Kido, H. B. Kim, J. H. Kim, S. W. Kim, Y. Kimura, I. Komae, Y. Kubota, M. Kuznetsov, Y. J. Kwon, K. H. Lee, B. Lubsandorzhiev, J. P. Lundquist, T. Matsuyama, J. N. Matthews, R. Mayta, I. Myers, S. Nagataki, K. Nakai, R. Nakamura, T. Nakamura, A. Nakazawa, E. Nishio, T. Nonaka, S. Ogio, M. Ohnishi, H. Ohoka, Y. Oku, T. Okuda, Y. Omura, M. Ono, A. Oshima, S. Ozawa, I. H. Park, M. Potts, M. S. Pshirkov, D. C. Rodriguez, C. Rott, G. I. Rubtsov, D. Ryu, H. Sagawa, N. Sakaki, T. Sako, N. Sakurai, K. Sato, T. Seki, K. Sekino, P. D. Shah, Y. Shibasaki, N. Shibata, T. Shibata, J. Shikita, H. Shimodaira, B. K. Shin, H. S. Shin, D. Shinto, J. D. Smith, P. Sokolsky, B. T. Stokes, T. A. Stroman, K. Takahashi, M. Takamura, M. Takeda, R. Takeishi, A. Taketa, M. Takita, Y. Tameda, K. Tanaka, M. Tanaka, S. B. Thomas, G. B. Thomson, P. Tinyakov, I. Tkachev, H. Tokuno, T. Tomida, S. Troitsky, R. Tsuda, Y. Tsunesada, S. Udo, T. Uehama, F. Urban, D. Warren, T. Wong, M. Yamamoto, K. Yamazaki, K. Yashiro, F. Yoshida, Y. Zhezher, Z. Zundel

Publikováno v: Geophysical Research Letters, Vol 50, Iss 14, Pp n/a-n/a (2023)

Abstract In this paper, we present the first high‐speed video observation of a cloud‐to‐ground lightning flash and its associated downward‐directed Terrestrial Gamma‐ray Flash (TGF). The optical emission of the event was observed by a high�

Externí odkaz: https://doaj.org/article/6abfefcf5d0a4b1a8d8cbe1c938c959c

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages

Autor: Kizzmekia S. Corbett, Syed M. Moin, Hadi M. Yassine, Alberto Cagigi, Masaru Kanekiyo, Seyhan Boyoglu-Barnum, Sky I. Myers, Yaroslav Tsybovsky, Adam K. Wheatley, Chaim A. Schramm, Rebecca A. Gillespie, Wei Shi, Lingshu Wang, Yi Zhang, Sarah F. Andrews, M. Gordon Joyce, Michelle C. Crank, Daniel C. Douek, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Jeffrey C. Boyington

Publikováno v: mBio, Vol 10, Iss 1 (2019)

ABSTRACT Influenza vaccines targeting the highly conserved stem of the hemagglutinin (HA) surface glycoprotein have the potential to protect against pandemic and drifted seasonal influenza viruses not covered by current vaccines. While HA stem-based

Externí odkaz: https://doaj.org/article/cd997d727dab4f9a9bff7e2660bf416f

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Supplementary File 2 from Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance

Autor: Ian F. Pollack, Andrew M. Stern, Mark E. Schurdak, D. Lansing Taylor, Ansuman Chattopadhyay, Max I. Myers, Stephen C. Mack, Kelsey C. Bertrand, Sameer Agnihotri, Brian Golbourn, Swetha Thambireddy, Daniel R. Premkumar, Esther P. Jane

Supplemental File 2: Genes common to all resistant U87 cell lines compared to drug naive control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f7077cb773aa084ad299586693d6ac
https://doi.org/10.1158/1541-7786.22514064