Zobrazeno 1 - 10
of 65
pro vyhledávání: '"I M Goldstein"'
Publikováno v:
The Journal of Experimental Medicine
Human PMN release lysosomal enzymes (beta-glucuronidase, acid phosphatase) when exposed to immune complexes, but do not release cytoplasmic LDH. The cells remain viable, and failure of LDH to appear in supernatants is not due to selective absorption
Publikováno v:
Journal of Clinical Investigation. 86:341-346
In the course of examining the structure and function of Fc receptors on peripheral blood cells of patients with systemic lupus erythematosus, we identified a patient whose neutrophils did not react with either monoclonal or polyclonal antibodies to
Publikováno v:
The Journal of Immunology. 131:397-402
The thiol proteinase cathepsin H, isolated and purified from rat liver lysosomes, provokes acute inflammation characterized by the accumulation of polymorphonuclear leukocytes (PMN) when injected intracutaneously into newborn rats. We have examined t
Publikováno v:
The Journal of Immunology. 143:1731-1734
IgG Fc receptor II (Fc gamma RII) on human monocytes is polymorphic with respect to its appearance on gels after isoelectric focusing and with respect to its ability to mediate T lymphocyte proliferation induced by murine anti-CD3 mAb of the IgG1 iso
Publikováno v:
Journal of Clinical Investigation. 78:1589-1595
The chemotactic activity of human C5a des Arg is enhanced significantly by an anionic polypeptide (cochemotaxin) in normal human serum and plasma. We have found that the cochemotaxin attaches to the oligosaccharide chain of native C5a des Arg to form
Publikováno v:
The Journal of Immunology. 134:3325-3331
We examined responses of human peripheral blood polymorphonuclear leukocytes (PMN) and monocytes to the highly purified human complement-derived peptides C5a and C5a des Arg. As reported previously, C5a proved to be approximately 10- to 20-fold more
Autor:
I M Goldstein, S Shak
Publikováno v:
Journal of Biological Chemistry. 259:10181-10187
Leukotriene B4 (LTB4), formed by the 5-lipoxygenase pathway in human polymorphonuclear leukocytes (PMN), may be an important mediator of inflammation. Recent studies suggest that human leukocytes can convert LTB4 to products that are less biologicall
Publikováno v:
The Journal of Immunology. 129:2718-2724
Evidence that surface membrane glycoproteins of polymorphonuclear leukocytes (PMN) are involved in stimulus-response coupling prompted us to examine effects on these cells of various plant lectins. We have found that wheat germ agglutinin (WGA) (1.0
Publikováno v:
The Journal of Immunology. 126:800-804
The potent chemoattractant, C5a is converted rapidly to C5a des Arg by a carboxypeptidase-like enzyme in normal human serum and plasma. Highly purified human C5a des Arg, at concentrations less than 120 ng/ml, is devoid of chemotactic activity for po
Publikováno v:
Journal of Biological Chemistry. 260:13023-13028
Human polymorphonuclear leukocytes (PMN) not only generate and respond to leukotriene B4 (LTB4), but also catabolize this mediator of inflammation rapidly and specifically by omega-oxidation (probably due to the action of a cytochrome P-450 enzyme).