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Design and Synthesis of Benzofuranic Derivatives as Potential Inhibitors of Hydroxyindole-O-methyltransferase

Autor: I. Le Picard, P. Depreux, I. Lesieur, P. Delagrange, C. Bennejean, P. Renard, P. Voisin

Publikováno v: Pharmacy and Pharmacology Communications. 5:177-181

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac96913ae418363b9672b1f62e7487a8
https://doi.org/10.1211/146080899128734767

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Design and Synthesis of Naphthalenic Derivatives as Potential Inhibitors of Hydroxyindole-O-methyltransferase

Autor: P. Voisin, Philippe Delagrange, I. Lesieur, P. Depreux, I. Le Picard, Pierre Renard, Caroline Bennejean

Publikováno v: Pharmacy and Pharmacology Communications. 5:183-188

Hydroxyindole-O-methyltransferase is an enzyme that catalyses the last step of melatonin biosynthesis. The objective of this work was to design and synthesize potential inhibitors of hydroxyindole-O-methyltransferase. Applying bioisosteric principles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::984bb5debc09fae56329c057622ccdd7
https://doi.org/10.1211/146080899128734578

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Oxidative degradation of cholesteryl esters in low-density lipoproteins: analysis by liquid chromatography-light scattering and protection by a new synthetic antioxidant, S20478

Autor: M. Arborati, B. Guardiola-Lemaitre, Ewa Ninio, JG Bizot-Espiard, MJ Chapman, I. Lesieur, D. Benchorba

Publikováno v: Fundamental & Clinical Pharmacology. 11:68-77

Cholesteryl esters in the hydrophobic core of low-density lipoprotein (LDL) particles constitute a major molecular target during copper-mediated oxidation. To facilitate the rapid analysis and quantitation of the oxidative degradation of LDL choleste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68be399bf1650c7eded54f3cc252440c
https://doi.org/10.1111/j.1472-8206.1997.tb00171.x

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4-(2-Carboxybenzoyl)-2(3H)-benzothiazolone

Autor: I. Lesieur, François Baert, T. Taverne, R. Houssin, J. Lamiot

Publikováno v: Acta Crystallographica Section C Crystal Structure Communications. 51:1912-1915

Although 6-benzoyl-2(3H)-benzothiazolone derivatives are known, their 4-benzoyl analogues have not been described previously. The title compound [2-(2-oxo-3H-1,3-benzothiazol-4-oyl)benzoic acid, C 15 H 9 NO 4 S] is the first of this series to be isol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d970a94836398fd73c70acddd340f26
https://doi.org/10.1107/s0108270195003179

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ChemInform Abstract: Synthesis of Indanyl Analogs of 3-(3-(4-Arylpiperazin-1-yl)propyl)-2- oxo-2,3-dihydro(1,3)benzoxazoles

Autor: Patrick Depreux, H. Aichaoui, I. Lesieur

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e446496ba20969b2a7c77e4732fb3ca
https://doi.org/10.1002/chin.199331175

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Amino ketone and amino alcohol derivatives of benzoxazolinone: synthesis, adrenergic and antihypertensive properties

Autor: JP Bonte, M. Beaughard, G. Dureng, J. C. Lamar, I Lesieur, MC Piancastelli

Publikováno v: European Journal of Medicinal Chemistry. 25:361-368

The concept of bioisosterism between benzoxazolinone and pyrocatechol has led to the synthesis of benzoxazolinone analogues of the catecholamines which display β- and α-blocking properties. In this paper, we report the synthesis of analogues in whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14130164ad13e9bbb7fff75fe7d9027c
https://doi.org/10.1016/0223-5234(90)90120-r

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Structure du chlorhydrate de (diméthylamino méthyl)-2 acrylophénone

Autor: J. P. Wignacourt, I. Lesieur, Daniel Lesieur, J. C. Boivin, Claudine Follet-Houttemane

Publikováno v: Acta Crystallographica Section C Crystal Structure Communications. 47:602-604

C 12 H 16 NO + •Cl − cristallise dans P2 1 /c avec a=9,903, b=11,331, c=11,272 A, β=98,18°, Z=4; affinement jusqu'a R=0,032. La molecule est dans une configuration etendue; le plan aromatique forme un angle de 57° avec le plan moyen du dimethy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94fabe600799ca09699a512d163ba972
https://doi.org/10.1107/s0108270190007545

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