Zobrazeno 1 - 10
of 125
pro vyhledávání: '"I K, Martin"'
Autor:
Nikolay Bogush, Lin Tan, Hussain Naib, Ebrahim Faizullabhoy, John W. Calvert, Siiri E. Iismaa, Ankan Gupta, Ramani Ramchandran, David I. K. Martin, Robert M. Graham, Ahsan Husain, Nawazish Naqvi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Cardiomyocytes of newborn mice proliferate after injury or exposure to growth factors. However, these responses are diminished after postnatal day-6 (P6), representing a barrier to building new cardiac muscle in adults. We have previously sh
Externí odkaz:
https://doaj.org/article/fd5f777a271c4c42af5f2172602fd2f5
Autor:
Jennifer E Chung, Wendy Magis, Jonathan Vu, Seok-Jin Heo, Kirmo Wartiovaara, Mark C Walters, Ryo Kurita, Yukio Nakamura, Dario Boffelli, David I K Martin, Jacob E Corn, Mark A DeWitt
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0208237 (2019)
Sickle Cell Disease and ß-thalassemia, which are caused by defective or deficient adult ß-globin (HBB) respectively, are the most common serious genetic blood diseases in the world. Persistent expression of the fetal ß-like globin, also known as
Externí odkaz:
https://doaj.org/article/94cd1619cf894c0da958464cf1a067e6
Autor:
Martin A. Kennedy, Pui-Yan Kwok, Dario Boffelli, Walfred Ma, David I. K. Martin, Jennifer McCaffrey, Steven Pastor, Yulia Mostovoy, Ilea E. Heft, Aaron J. Stevens, James M. Sikela, Ming Xiao, Michal Levy-Sakin
Publikováno v:
Genetics
Genetics, vol 214, iss 1
Genetics, vol 214, iss 1
Olduvai (formerly DUF1220) protein domains have undergone the largest human-specific increase in copy number of any coding region in the genome (∼300 copies of which 165 are human-specific) and have been implicated in human brain evolution... Seque
Autor:
Robert M. Graham, John W. Calvert, Hussain Naib, David I. K. Martin, Jennifer Perry, Nawazish Naqvi, Lin Tan, Nikolay Bogush, Ahsan Husain
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Mitochondria-generated reactive oxygen species (mROS) are frequently associated with DNA damage and cell cycle arrest, but physiological increases in mROS serve to regulate specific cell functions. T3 is a major regulator of mROS, including hydrogen
Autor:
Wendy, Magis, Mark A, DeWitt, Stacia K, Wyman, Jonathan T, Vu, Seok-Jin, Heo, Shirley J, Shao, Finn, Hennig, Zulema G, Romero, Beatriz, Campo-Fernandez, Suzanne, Said, Matthew S, McNeill, Garrett R, Rettig, Yongming, Sun, Yu, Wang, Mark A, Behlke, Donald B, Kohn, Dario, Boffelli, Mark C, Walters, Jacob E, Corn, David I K, Martin
Publikováno v:
iScience. 25(6)
A point mutation in sickle cell disease (SCD) alters one amino acid in the β-globin subunit of hemoglobin, with resultant anemia and multiorgan damage that typically shortens lifespan by decades. Because SCD is caused by a single mutation, and hemat
Autor:
Lin Tan, Ankan Gupta, Siiri E. Iismaa, Nawazish Naqvi, John W. Calvert, David I. K. Martin, Hussain Naib, Ahsan Husain, Robert M. Graham, Ramani Ramchandran, Ebrahim Faizullabhoy, Nikolay Bogush
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
A developmental surge in thyroid hormone (T3) after postnatal day-10 (P10), in mice, results in a burst of cardiomyocyte proliferation. This finding remains controversial, which could arise from perceived homogeneity of myocardial sampling for immuno
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82573 (2013)
Piwi proteins and their small non-coding RNA partners are involved in the maintenance of stem cell character and genome integrity in the male germ cells of mammals. MIWI2, one of the mouse Piwi-like proteins, is expressed in the prepachytene phase of
Externí odkaz:
https://doaj.org/article/45ab350d10a6414189d0dee5f2c323ed
Autor:
Walfred Ma, Jen-Ping Su, Wan-Jia Lin, Wuh-Liang Hwu, Jer-Yuarn Wu, Ming Xiao, Yu-Feng Hu, Annie Poon, Catherine J. Chu, Hsiao-Jung Kao, Chi-Fan Yang, Pui-Yan Kwok, Dario Boffelli, Dar-Shong Lin, Hsiao-Huei Chen, Ni-Chung Lee, Eleanor Young, David I. K. Martin, C. M. Wei, Stephen K. Chow, Elin H. F. Wang, Erh-Chan Yeh, Karen H. Y. Wong, Feng-Jen Hsieh
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature communications, vol 11, iss 1
The current human reference genome is predominantly derived from a single individual and it does not adequately reflect human genetic diversity. Here, we analyze 338 high-quality human assemblies of genetically divergent human populations to identify
Autor:
Cheryl C Y Li, Jennifer E Cropley, Mark J Cowley, Thomas Preiss, David I K Martin, Catherine M Suter
Publikováno v:
PLoS Genetics, Vol 7, Iss 4, p e1001380 (2011)
Epigenetic changes can be induced by adverse environmental exposures, such as nutritional imbalance, but little is known about the nature or extent of these changes. Here we have explored the epigenomic effects of a sustained nutritional change, exce
Externí odkaz:
https://doaj.org/article/21344088d00b45d6ab637efa00110c01
Autor:
Joseph M Dhahbi, Hani Atamna, Dario Boffelli, Wendy Magis, Stephen R Spindler, David I K Martin
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20509 (2011)
In cell senescence, cultured cells cease proliferating and acquire aberrant gene expression patterns. MicroRNAs (miRNAs) modulate gene expression through translational repression or mRNA degradation and have been implicated in senescence. We used dee
Externí odkaz:
https://doaj.org/article/b8f8b8f3e29540e89619990bf2e94abc