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Interactions of ginsenosides with ligand-bindings of GABAA and GABAB receptors

Autor: Hack-Seang Kim, T. Kimura, I. K. Ho, Ki Wan Oh, P.A. Saunders, H.M. Rheu

Publikováno v: General Pharmacology: The Vascular System. 25:193-199

1. 1. Total saponin fraction decreased the affinity of specific [ 3 H]muscimol binding without changes in B max . Ginsenoside Rb 1 Rb 2 , Rc, Re, Rf and Rg 1 inhibited the specific [ 3 H]muscimol binding to the high-affinity site. 2. 2. Total saponin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341ce53ccbaed78c26764344dd067284
https://doi.org/10.1016/0306-3623(94)90032-9

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Modulation of the levels of NMDA receptor subunit mRNA and the bindings of [3H]MK-801 in rat brain by chronic infusion of subtoxic dose of MK-801

Autor: S, Oh, Y H, Kim, H J, Hann, H L, Lee, H S, Choi, H S, Kim, I K, Ho

Publikováno v: Neurochemical research. 26(5)

The effects of continuous infusion of NMDA receptor antagonist MK-801 on the modulation of NMDA receptor subunits NR1, NR2A, NR2B, and NR2C were investigated by using in situ hybridization study. Differential assembly of NMDA receptor subunits determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af7b4edb05273a3a60b8a4dbe21975b5
https://pubmed.ncbi.nlm.nih.gov/11513485

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Modulation of NMDA receptor subunit mRNA in butorphanol-tolerant and -withdrawing rats

Autor: S, Oh, J I, Kim, M W, Chung, I K, Ho

Publikováno v: Neurochemical research. 25(12)

The NMDA receptor has been implicated in opioid tolerance and withdrawal. The effects of continuous infusion of butorphanol on the modulation of NMDA receptor subunit NR1, NR2A, NR2B, and NR2C gene expression were investigated by using in situ hybrid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87dc0e422fb338900c10273f79550659
https://pubmed.ncbi.nlm.nih.gov/11152389

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Metabolism of a novel hypnotic, N3-phenacyluridine, and hypnotic and sedative activities of its enantiomer metabolites in mouse

Autor: K. Watanabe, Toshiyuki Kimura, I. K. Ho, M. Miki, I. Yamamoto, S. Kondo

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 30(6)

1. The metabolism of N3-phenacyluridine (3-phenacyl-1-beta-D-ribofuranosyluracil), a potent hypnotic nucleoside derivative, was studied in mouse. 2. Of the radioactivity, 65% was excreted in urine within 48 h after intraperitoneal (i.p.) administrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050755827976b8dfb02be7c23fd0bc16
https://pubmed.ncbi.nlm.nih.gov/10923865

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Changes of [3H]muscimol binding and GABA(A) receptor beta2-subunit mRNA level by tolerance to and withdrawal from pentobarbital in rats

Autor: S, Oh, I K, Ho

Publikováno v: Neurochemical research. 24(12)

Effects of continuous pentobarbital administration on binding characteristics of [3H]muscimol were examined by autoradiography, and levels of GABA(A) receptor beta2-subunit mRNA were investigated by in situ hybridization histochemistry in the rat bra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c422c26d5207989fcb88bd73d838df57
https://pubmed.ncbi.nlm.nih.gov/10591412

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Protein kinase C in rat brain is altered by developmental lead exposure

Autor: H H, Chen, T, Ma, I K, Ho

Publikováno v: Neurochemical research. 24(3)

The absence of learning-related redistribution of hippocampal protein kinase C (PKC) has been correlated with impairment of learning performance induced by developmental lead (Pb) exposure. This study was designed to examine whether the properties of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21b9bcd5d885bc36695f6d1b9081de9c
https://pubmed.ncbi.nlm.nih.gov/10215516

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Withdrawal from butorphanol dependence alters binding of [3H]phorbol dibutyrate to protein kinase C, but not of [3H]forskolin to adenylate cyclase

Autor: C G, Jang, R W, Rockhold, I K, Ho

Publikováno v: Brain research. 821(2)

The time course of autoradiographic binding of major second messengers in the rat brain was studied at 2, 7, and 24 h after withdrawal from butorphanol infusion. [3H]Forskolin and [3H]phorbol 12,13-dibutyrate (PDBu) were used to label adenylate cycla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e47379c4c6a300e25811d01c79153a4c
https://pubmed.ncbi.nlm.nih.gov/10064840

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Changes in NMDAR2 subunit mRNA levels during pentobarbital tolerance/withdrawal in the rat brain: an in situ hybridization study

Autor: C G, Jang, S, Oh, I K, Ho

Publikováno v: Neurochemical research. 23(11)

Little is known about the functional modulation of NMDA receptor subunits at the molecular level. Therefore, a series of experiments were conducted to elucidate more fully the role of NMDA receptor subtypes in pentobarbital tolerance and withdrawal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbfc5e73da63cfe64c56530349771986
https://pubmed.ncbi.nlm.nih.gov/9814547

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Excitatory amino acids and lead-induced neurotoxicity

Autor: I. K. Ho, A. S. Hume, T. Ma, D. K. Lim, Hwei-Hsien Chen

Publikováno v: The Journal of toxicological sciences. 23

The NMDA receptor non-competitive antagonist, [3H]MK-801, was used as a ligand for an autoradiographic study to determine the effects of lead on NMDA receptor in rat brain. Adult male rats were given lead acetate, 100 mg/kg, or sodium acetate, 36 mg/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6dce7a99d0e9844d9d52ff0319110ee
https://pubmed.ncbi.nlm.nih.gov/9760459

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