Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation

Autor: Widdowson Katherine L, Lorena A. Kallal, Yvett Sosa, Matthew S. Steiginga, Michael T. Ouellette, Myles H. Akabas, I. J. Frame, Andrew J. Pope, Roman Deniskin, Todd L. Graybill, Deepak Bandyopadhyay, Robert J. Young

Publikováno v: ACS Infectious Diseases. 5:1738-1753

Emerging resistance to current antimalarial medicines underscores the importance of identifying new drug targets and novel compounds. Malaria parasites are purine auxotrophic and import purines via the Plasmodium falciparum equilibrative nucleoside t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19f40902415475df50da84cc0ab7b2af
https://doi.org/10.1021/acsinfecdis.9b00168

Targeting the Plasmodium vivax equilibrative nucleoside transporter 1 (PvENT1) for antimalarial drug development

Autor: I. J. Frame, Myles H. Akabas, Yvett Sosa, Roman Deniskin

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 1-11 (2016)
International Journal for Parasitology: Drugs and Drug Resistance

Infection with Plasmodium falciparum and vivax cause most cases of malaria. Emerging resistance to current antimalarial medications makes new drug development imperative. Ideally a new antimalarial drug should treat both falciparum and vivax malaria.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d369a70028fd3fb4d411b54bb547d0d
https://doi.org/10.1016/j.ijpddr.2015.11.003

Purine import into malaria parasites as a target for antimalarial drug development

Autor: Avish Arora, I. J. Frame, Myles H. Akabas, Roman Deniskin

Publikováno v: Annals of the New York Academy of Sciences. 1342:19-28

Infection with Plasmodium species parasites causes malaria. Plasmodium parasites are purine auxotrophs. In all life cycle stages, they require purines for RNA and DNA synthesis and other cellular metabolic processes. Purines are imported from the hos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f0800502ff98eae7117d206d626f027
https://doi.org/10.1111/nyas.12568

Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity

Autor: Myles H. Akabas, I. J. Frame, Maria B. Cassera, Emilio F. Merino, Vern L. Schramm

Publikováno v: Biochemical Journal. 446:179-190

Malaria, caused by Plasmodia parasites, affects hundreds of millions of people. As purine auxotrophs, Plasmodia use transporters to import host purines for subsequent metabolism by the purine salvage pathway. Thus purine transporters are attractive d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d437031fef84a44699e2f6ff6f412ec
https://doi.org/10.1042/bj20112220

Purine import into malaria parasites as a target for antimalarial drug development

Autor: I J, Frame, Roman, Deniskin, Avish, Arora, Myles H, Akabas

Publikováno v: Annals of the New York Academy of Sciences. 1342

Infection with Plasmodium species parasites causes malaria. Plasmodium parasites are purine auxotrophs. In all life cycle stages, they require purines for RNA and DNA synthesis and other cellular metabolic processes. Purines are imported from the hos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d65dab304ae0bb7e54aee42a2247595
https://pubmed.ncbi.nlm.nih.gov/25424653