Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat.

Autor: Corner TP; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.; Present Address: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, 06511, United States of America., Salah E; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Tumber A; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Kaur S; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Nakashima Y; Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan., Allen MD; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Schnaubelt LI; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Fiorini G; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Brewitz L; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Dec 16; Vol. 19 (24), pp. e202400504. Date of Electronic Publication: 2024 Nov 08.

Machine Learning Guided Rational Design of a Non-Heme Iron-Based Lysine Dioxygenase Improves its Total Turnover Number.

Autor: Hunter Wilson R; Department of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN-55455, United States., Diaz DJ; Department of Chemistry, Department of Computer Science, University of Texas at Austin, Austin, TX-78705, United States.; Institute for Foundations of Machine Learning, University of Texas at Austin, Austin, TX-78705, United States., Damodaran AR; Department of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN-55455, United States., Bhagi-Damodaran A; Department of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN-55455, United States.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Oct 06, pp. e202400495. Date of Electronic Publication: 2024 Oct 06.

No lung cancer at resection of PET positive lesions: an audit of the lung cancer multidisciplinary team

Autor: M. F. Muers, I. J. Clifton, Andrew Scarsbrook

Publikováno v: The European respiratory journal. 33(4)

To the Editors: An essential role of the lung cancer multidisciplinary team (MDT) is to provide an accurate and prompt diagnosis enabling resection of malignant disease where appropriate, while minimising the risk of unnecessary surgical intervention

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7e4c6dcda36bd73f87cea51f65e7fb
https://pubmed.ncbi.nlm.nih.gov/19336598

Laue film integration and deconvolution of spatially overlapping reflections

Autor: Annette K. Shrive, I. J. Clifton, Trevor J. Greenhough, Janos Hajdu

Publikováno v: Journal of Applied Crystallography. 23:169-174

Single-crystal synchrotron-radiation Laue photographs of protein crystals and viruses are densely populated and a considerable amount of spatial overlapping of spots often occurs on the films. An integration procedure which enables the efficient deco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad42a369e80bb48ef236301baa80a48b
https://doi.org/10.1107/s0021889890000346

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate

Autor: R C, Wilmouth, K, Edman, R, Neutze, P A, Wright, I J, Clifton, T R, Schneider, C J, Schofield, J, Hajdu

Publikováno v: Nature structural biology. 8(8)

Studies on the catalytic mechanism and inhibition of serine proteases are widely used as paradigms for teaching enzyme catalysis. Ground-breaking work on the structures of chymotrypsin and subtilisin led to the idea of a conserved catalytic triad for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c9b84f11c600264964c067a89c605608
https://pubmed.ncbi.nlm.nih.gov/11473259