Výsledky vyhledávání - "I J, Barrett"

Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing

Autor: I. J. Barrett, Yasaman Nouhi, Kirk J. McManus, Philip Hieter

Publikováno v: Proceedings of the National Academy of Sciences. 106:3276-3281

Mutations that cause chromosome instability (CIN) in cancer cells produce “sublethal” deficiencies in an essential process (chromosome segregation) and, therefore, may represent a major untapped resource that could be exploited for therapeutic be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f638d15fe256f9d65ea0e0b9bd3620fb
https://doi.org/10.1073/pnas.0813414106

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An association between skewed X-chromosome inactivation and abnormal outcome in mosaic trisomy 16 confined predominantly to the placenta

Autor: S-L Yong, Suzanne M E Lewis, Wendy P. Robinson, Patricia N. Howard-Peebles, Sylvie Langlois, I. J. Barrett, Helene Bruyere, Carolyn J. Brown, Dagmar K. Kalousek, Peñaherrera

Publikováno v: Clinical Genetics. 58:436-446

Skewed X-chromosome inactivation (XCI) is frequently found in the diploid fetal tissues of individuals with mosaic trisomy that originated from a 'trisomic zygote rescue' event. This may result from a high number of trisomic cells in the embryonic ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19410059b1aa4384beddd6ffdc7791fa
https://doi.org/10.1034/j.1399-0004.2000.580603.x

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Genome-Wide Synthetic Lethal Screens Identify an Interaction Between the Nuclear Envelope Protein, Apq12p, and the Kinetochore in Saccharomyces cerevisiae

Autor: Phil Hieter, Ken Thorne, Ravi Jadusingh, Kim Andrews, Vivien Measday, I. J. Barrett, Ben Montpetit

Publikováno v: Genetics. 171:489-501

The maintenance of genome stability is a fundamental requirement for normal cell cycle progression. The budding yeast Saccharomyces cerevisiae is an excellent model to study chromosome maintenance due to its well-defined centromere and kinetochore, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0deadb8dcd177d788d075c60526ed07f
https://doi.org/10.1534/genetics.105.045799

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Prenatally detected trisomy 20 mosaicism

Autor: M. E. S. Lewis, Barbara McGillivray, Dagmar K. Kalousek, Wendy P. Robinson, I. J. Barrett, Laura Arbour

Publikováno v: Prenatal Diagnosis. 25:239-244

Background Trisomy 20 is one of the more common mosaic trisomies detected on amniocentesis and presents with a normal outcome in over 90% of reported cases. Trisomic cells are almost never confirmed in newborn blood and are only rarely found in other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a544a93de91e2994c4b99b4a620fda
https://doi.org/10.1002/pd.1121

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Two cases of confined placental mosaicism for chromosome 4, including one with maternal uniparental disomy

Autor: Siu-Li Yong, Dagmar K. Kalousek, G. Moya, Brian D. Kuchinka, J. M. Sánchez, Sylvie Langlois, Wendy P. Robinson, I. J. Barrett

Publikováno v: Prenatal Diagnosis. 21:36-39

Two cases of trisomy 4 mosaicism are reported including one with molecularly confirmed uniparental disomy (UPD) of chromosome 4. Cytogenetic analysis of a chorionic villus sample (CVS) in Case 1 showed complete trisomy 4 in trophoblast and diploidy i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d4433053d742b37fb878f4ff0bac558
https://doi.org/10.1002/1097-0223(200101)21:1<36::aid-pd979>3.0.co

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Comparative Genomic Hybridization

Autor: Dagmar K. Kalousek, I. J. Barrett, Brenda Lomax, Tatiana Loukianova, Steven S. Tang, Valia S. Lestou

Publikováno v: Archives of Pathology & Laboratory Medicine. 125:81-84

Objective.—To demonstrate the effectiveness of comparative genomic hybridization (CGH) for analysis of reproductive pathology specimens in clinical cytogenetics laboratories. Design.—A total of 856 CGH analyses were performed on various placental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::096205f5d6c3db2f7ef3491fa87dacfc
https://doi.org/10.5858/2001-125-0081-cgh

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Comparative genomic hybridization: A new approach to screening for intrauterine complete or mosaic aneuploidy

Autor: R. D. Wilson, I. J. Barrett, Valia S. Lestou, V. Desilets, Dagmar K. Kalousek, Sylvie Langlois, Brenda Lomax

Publikováno v: American Journal of Medical Genetics. 92:281-284

In the practice of clinical genetics chromosomal aneuploidy in both mosaic and nonmosaic forms has long been recognized as a cause of abnormal prenatal and postnatal development. Traditionally, cytogenetic analysis of cultured lymphocytes has been us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a22c52d4ae7a223d9bccf164f7c92b1
https://doi.org/10.1002/(sici)1096-8628(20000605)92:4<281::aid-ajmg12>3.0.co

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Screening of human placentas for chromosomal mosaicism using comparative genomic hybridization

Autor: I. J. Barrett, Dagmar K. Kalousek, Valia S. Lestou, Brenda Lomax

Publikováno v: Teratology. 59:325-330

Detection of confined placental mosaicism (CPM) in term placental tissues is usually accomplished by conventional cytogenetic analysis of cultured chorionic stroma and direct preparations from trophoblast or, more recently, by fluorescence in situ hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfb934b6ed12322e236534ac49312fbe
https://doi.org/10.1002/(sici)1096-9926(199905)59:5<325::aid-tera3>3.0.co

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