Zobrazeno 1 - 10
of 181
pro vyhledávání: '"I I, Singer"'
Autor:
H R Williams, C F Harper, John G. Flanagan, J R Weidner, E K Bayne, N I Hutchinson, S A Donatelli, I I Singer, L A Hoerrner, Michael W. Lark, L. S. Lohmander, R A Mumford
Publikováno v:
Scopus-Elsevier
To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage, metabolic fragments of aggrecan were detected with monospecific antipeptide antibodies. The distribution and quantity of MM
Autor:
I I Singer, D W Kawka, J A DeMartino, B L Daugherty, K O Elliston, K Alves, B L Bush, P M Cameron, G C Cuca, P Davies
Publikováno v:
The Journal of Immunology. 150:2844-2857
The murine anti-CD18 mAb 1B4 has been humanized using CDR grafting. Three VH (Gal, Jon, and New) and two VL (Rei and Len) human frameworks, whose selection was based exclusively on their sequence identity with m1B4, were used to construct five human
Autor:
G.-J. Shei, Richard Hajdu, Michael J. Forrest, V. White, Carol Ann Keohane, Richard L. Proia, Hugh Rosen, N. Nomura, Sander G. Mills, Jeffrey J. Hale, Suzanne M. Mandala, Mark Rosenbach, I. I. Singer, S.-Y. Sun, Jenny Xie, M. Tian, C. Meyers, James A. Milligan, Deborah Card, James D. Bergstrom, George A. Doherty, S. West
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 309(2)
Sphingosine 1-phosphate (S1P) is a bioactive lysolipid with pleiotropic functions mediated through a family of G protein-coupled receptors, S1P(1,2,3,4,5). Physiological effects of S1P receptor agonists include regulation of cardiovascular function a
Autor:
E K, Bayne, J, Flanagan, M, Einstein, J, Ayala, B, Chang, B, Azzolina, D A, Whiting, R A, Mumford, D, Thiboutot, I I, Singer, G, Harris
Publikováno v:
The British journal of dermatology. 141(3)
The predominant form of 5alpha-reductase (5aR) in human scalp is 5aR1. None the less, clinical studies have shown that finasteride, a selective inhibitor of 5aR2, decreases scalp dihydrotestosterone and promotes hair growth in men with androgenetic a
Publikováno v:
Arthritis and rheumatism. 42(6)
Two major cleavage sites, one mediated by metalloproteinases (MMPs) and the other by an as-yet unidentified enzyme termed aggrecanase, have been observed in aggrecan. To learn more about the relative contribution of these enzymes during cartilage deg
Publikováno v:
Arthritis and rheumatism. 41(4)
To investigate the relationship between occurrence of the matrix metalloproteinase-generated neoepitope VDIPEN and proteoglycan (PG) loss in arthritis, and to examine the role of interleukin-1 (IL-1) in VDIPEN expression.VDIPEN expression was investi
Autor:
J S, Mudgett, N I, Hutchinson, N A, Chartrain, A J, Forsyth, J, McDonnell, I I, Singer, E K, Bayne, J, Flanagan, D, Kawka, C F, Shen, K, Stevens, H, Chen, M, Trumbauer, D M, Visco
Publikováno v:
Arthritis and rheumatism. 41(1)
It has long been proposed that stromelysin is one of the major degradative matrix metalloproteinases responsible for the loss of cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA). This hypothesis was tested by examining the arthritic paw
Autor:
S L Rhode, I I Singer
Publikováno v:
Journal of Virology. 21:724-731
Partial denaturation mapping, restriction endonuclease digestion, and electron microscopy were used to determine which end of the linear duplex replicative-form (RF) DNA molecule contains the origin of RF replication for the parvovirus H-1. This orig
Autor:
I I, Singer
Publikováno v:
Journal of cell science. 56
In order to determine whether fibronexus morphogenesis is involved in the establishment of more normal cellular morphology and substrate adhesion patterns in Nil/HSV transformed fibroblasts induced by treatment with exogenous fibronectin (FN), this s
Autor:
I I, Singer, H W, Toolan
Publikováno v:
Virology. 65(1)