Zobrazeno 1 - 10
of 36
pro vyhledávání: '"I G Otterness"'
Publikováno v:
Mediators of Inflammation, Vol 3, Iss 4, Pp 243-256 (1994)
The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions by direct regulation of met
Externí odkaz:
https://doaj.org/article/da9745e75e0f4267bb0ad12c2fa04afb
Publikováno v:
Mediators of Inflammation, Vol 3, Iss 3, Pp 199-204 (1994)
Many studies in animals have examined biochemical, immune and histological changes during arthritis; however, the study of the effects of arthritis on mobility has been largely neglected. Interleukin-1, administered by the intraarticular route into h
Externí odkaz:
https://doaj.org/article/1edc84bbdb9f46718f5985caa07a8735
Publikováno v:
The Journal of Immunology. 154:4081-4090
IL-1 is a potent cytokine that promotes host defense and inflammation. These processes may be modulated by an IL-1 receptor antagonist (IL-1Ra) that binds to and blocks IL-1 receptors. The objective of this study was to define the cellular origin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22471c9543aaf77f7f152eaa76baf5b5
https://doi.org/10.4049/jimmunol.154.8.4081
https://doi.org/10.4049/jimmunol.154.8.4081
Publikováno v:
The Journal of Immunology. 154:2821-2828
The secretion of IL-1 from murine macrophages in vitro is an inefficient process that is distinct from those of other cytokines such as IL-6. We have therefore studied this process in vivo to see if these differences are maintained. Intraperitoneal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be1e30d4283733e28c400c1c2ddc099d
https://doi.org/10.4049/jimmunol.154.6.2821
https://doi.org/10.4049/jimmunol.154.6.2821
Publikováno v:
The Journal of Experimental Medicine
In situ production of interleukin 1 alpha (IL-1 alpha) and IL-1 beta was investigated in Peyer's patches (PP) of mice undergoing an acute bacterial infection with Yersinia enterocolitica O8. Synthesis of IL-1 beta, as determined by immunohistochemist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dea1aec546b15a7e0151a86e4a10b20
https://doi.org/10.1084/jem.175.6.1793
https://doi.org/10.1084/jem.175.6.1793
Autor:
H E, Grenett, D E, Danley, C A, Strick, L C, James, I G, Otterness, N, Fuentes, J E, Nesbitt, G M, Fuller
Publikováno v:
Gene. 101:267-271
Interleukin-6 (IL-6) is a multi-functional cytokine produced and secreted by several different cell types, including those of the immune system. A cDNA coding for the mature murine IL-6 (mIL-6), which extends from amino acid (aa) 25 through 211, was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a681d588c204fb9459e9c670aee70f
https://doi.org/10.1016/0378-1119(91)90422-8
https://doi.org/10.1016/0378-1119(91)90422-8
Publikováno v:
Drug Development and Industrial Pharmacy. 17:2391-2400
A sensitive and selective radioimmunoassay has been developed using a colchicine binding monoclonal antibody. The assay procedure uses a charcoal suspension to separate antibody bound and free colchicine and can be performed in less than two hours. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39d7a660551658a4c7e46fbc546741a0
https://doi.org/10.3109/03639049109048082
https://doi.org/10.3109/03639049109048082
Publikováno v:
Biochemistry. 39(24)
Protein-protein interactions (PPI) are a ubiquitous mode of transmitting signals in cells and tissues. We are testing a stepwise, generic, structure-driven approach for finding low molecular weight inhibitors of protein-protein interactions. The appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f667974e6a5f9083462465978da08540
https://pubmed.ncbi.nlm.nih.gov/10852706
https://pubmed.ncbi.nlm.nih.gov/10852706
Publikováno v:
Arthritis and rheumatism. 41(11)
It has been reported that osteoarthritis can occur in hamsters. The present study was undertaken to determine the effects of exercise on the composition of articular cartilage and synovial fluid and on the development of cartilage degeneration in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::497ecefc451d0fa067932b890680fbb0
https://pubmed.ncbi.nlm.nih.gov/9811063
https://pubmed.ncbi.nlm.nih.gov/9811063
Autor:
J C, Fernandes, J, Martel-Pelletier, D, Jovanovic, G, Tardif, J A, DiBattista, V, Lascau-Coman, I G, Otterness, J P, Pelletier
Publikováno v:
The Journal of rheumatology. 25(5)
To examine the effect of tenidap on the expression of collagenase- and interleukin 1beta (IL-1beta) genes in experimental canine osteoarthritis (OA).The anterior cruciate ligaments of the right stifle joints of experimental dogs were sectioned by a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25656b6b307a54525d6f177ec1494cf0
https://pubmed.ncbi.nlm.nih.gov/9598897
https://pubmed.ncbi.nlm.nih.gov/9598897