Výsledky vyhledávání - "I G, Chadwick"

Inhibition of CYP2D6 activity by treatment with propranolol and the role of 4-hydroxy propranolol

Autor: LE Ramsay, Wilfred W. Yeo, S W Ellis, I. G. Chadwick, Martin S. Lennard, K Rowland, I. U. Haq, Peter R. Jackson, Geoffrey T. Tucker

Publikováno v: British Journal of Clinical Pharmacology. 38:9-14

1. The 4-hydroxylation of propranolol by rat and human liver microsomes is associated with formation of a chemically reactive species which binds irreversibly to cytochrome P4502D6 (CYP2D6) destroying its catalytic function. Therefore, the effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4bc6b436ed638f2ed4bd46740f51261
https://doi.org/10.1111/j.1365-2125.1994.tb04315.x

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No relation between angiotensin-converting enzyme gene polymorphism and dermal response to bradykinin in healthy subjects

Autor: M. Kraskiewicz, KS Higgins, LE Ramsay, Peter R. Jackson, I. G. Chadwick, Wilfred W. Yeo

Publikováno v: Clinical science (London, England : 1979). 91(5)

1. The dermal wheal response to bradykinin is increased by drugs which inhibit angiotensin-converting enzyme, and thus provides a measure of angiotensin-converting enzyme activity at the tissue level. An insertion/deletion polymorphism of the angiote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67082772ea2bd48727bab6bd6dd8f478
https://pubmed.ncbi.nlm.nih.gov/8964127

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Resolution of ACE inhibitor cough: changes in subjective cough and responses to inhaled capsaicin, intradermal bradykinin and substance-P

Autor: W W, Yeo, I G, Chadwick, M, Kraskiewicz, P R, Jackson, L E, Ramsay

Publikováno v: British journal of clinical pharmacology. 40(5)

1. In eight hypertensive patients with ACE inhibitor-induced cough the resolution of the cough was examined in a prospective observational study over 4 weeks duration. Resolution of cough was measured by visual analogue scales and questionnaire at ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::796436e9b008804e9598dffab8426c6d
https://pubmed.ncbi.nlm.nih.gov/8703645

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Relation between changes in blood pressure and serum ACE activity after a single dose of enalapril and ACE genotype in healthy subjects

Autor: Peter R. Jackson, KS Higgins, Wilfred W. Yeo, I. G. Chadwick, LE Ramsay, G. P. A. Todd

1. The effects of a single oral dose of enalapril 10 mg on serum ACE activity and blood pressure in relation to the ACE genotype were studied in 27 healthy men, n = 9 each of genotype DD, ID and II, in a parallel group study design. 2. Before treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327a84af43488c5c0b6ab3d7da35d3a7
https://europepmc.org/articles/PMC1364949/

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Pressor effect of hyperventilation in healthy subjects

Autor: G P, Todd, I G, Chadwick, W W, Yeo, P R, Jackson, L E, Ramsay

Publikováno v: Journal of human hypertension. 9(2)

Hyperventilation is an important feature of panic disorder, and an association has been reported between panic disorder and hypertension. We have examined the effect of hyperventilation on the blood pressure (BP) of healthy subjects. Twenty six subje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee5cfe204b521fc348e284612cb75f63
https://pubmed.ncbi.nlm.nih.gov/7752173

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Non-pharmacological therapy of hypertension

Autor: Peter R. Jackson, I. G. Chadwick, Wilfred W. Yeo, LE Ramsay

Publikováno v: British medical bulletin. 50(2)

Weight reduction, moderate sodium restriction and alcohol reduction all lower blood pressure significantly in the short-term, and appear feasible in the long-term. Dynamic exercise may have a useful role in selected patients. Cessation of cigarette s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fae4d4cba98536ae103c326d62a320
https://pubmed.ncbi.nlm.nih.gov/8205470

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