Zobrazeno 1 - 10
of 19
pro vyhledávání: '"I F, McMurtry"'
Publikováno v:
Respiratory Research
Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of
Publikováno v:
Hepatology (Baltimore, Md.). 22(6)
The present experiments were designed to test if induction of nitric oxide synthase (NOS) plays a role in the systemic vasodilation observed in hepatic cirrhosis. Because endotoxin levels are elevated in cirrhosis, and endotoxin stimulates inducible
Publikováno v:
Chest. 93:88S-93
Publikováno v:
The American review of respiratory disease. 130(1)
There exists no agreement as to the best vasodilator drug for treatment of hypoxic pulmonary hypertension. We wondered which of 3 commonly used vasodilators - verapamil, nifedipine, or hydralazine - would be the most effective in reducing and reversi
Publikováno v:
The American review of respiratory disease. 127(5)
A good model of the adult respiratory distress syndrome (ARDS) is intravenously injected phorbol myristate acetate (PMA), which causes pulmonary sequestration of neutrophils and a neutrophil-dependent acute edematous lung injury in rabbits. In the pr
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 248(3)
This study was undertaken to test if isolated rat pulmonary artery (PA) rings contract in response to hypoxia, if the response behaves similarly to previously described physiologic and pharmacologic features of hypoxic pulmonary vasoconstriction (HPV
Publikováno v:
Bulletin europeen de physiopathologie respiratoire. 23(3)
The possibility that changes in energy metabolism are involved in oxygen sensing during hypoxic pulmonary vasoconstriction was tested indirectly by measurement of hypoxic-pressor reactivity in lungs isolated from rats with low and high levels of plas
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 236(2)
Recent reports have shown that cultured endothelial cells release into the culture medium a substance (or substances) that contracts isolated preparations of arterial smooth muscle [endothelial-derived constrictor factor (EDCF)]. To evaluate the coro
Publikováno v:
The American review of respiratory disease. 126(5)
Oxygen radicals have been implicated in the pathogenesis of permeability pulmonary edema. To determine directly if O2 radicals can cause increased alveolar-capillary membrane (ACM) permeability and low-pressure permeability edema, we chemically produ
Autor:
I. F. McMurtry, B. Raffestin
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 63(6)
Isolated rat lungs perfused with physiological salt-Ficoll solutions were studied to test whether hypoxic pulmonary vasoconstriction was potentiated by increases in intracellular pH (pHi) and blunted by decreases in pHi. Whereas addition to perfusate