Zobrazeno 1 - 10
of 54
pro vyhledávání: '"I E, Karl"'
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 271:R1165-R1172
The aims of this work were to establish whether glutamine infusion via alanyl-glutamine dipeptide provides effective therapy against muscle atrophy from glucorticoids and whether the glucocorticoid induction of glutamine synthetase (GS) is downregula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96409d3c6eae908b2c0cdc2b74551ca
https://doi.org/10.1152/ajpregu.1996.271.5.r1165
https://doi.org/10.1152/ajpregu.1996.271.5.r1165
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 270:E912-E917
Skeletal muscle atrophy from glucocorticoids is prevented by glutamine infusion. Because the gene-encoding glutamine synthetase (GS) is glucocorticoid inducible, it represented an appropriate model for resting whether glucocorticoids and glutamine ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635b347a5e1d7d76657109410ee7f5ac
https://doi.org/10.1152/ajpendo.1996.270.5.e912
https://doi.org/10.1152/ajpendo.1996.270.5.e912
Autor:
Joseph J. H. Ackerman, J. L. Neil, Richard S. Hotchkiss, Oliver H. Lowry, R. D. Chen, I. E. Karl, J. K. Manchester, Sheng-Kwei Song
Publikováno v:
American Journal of Physiology-Cell Physiology. 260:C50-C57
Sepsis has been reported to cause mitochondrial dysfunction and inhibition of key enzymes that regulate the tricarboxylic acid (TCA) cycle. We investigated the effect of sepsis on high-energy phosphates, glycolytic and TCA cycle intermediates, and sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f52464bb55a2b48ee488d104d5ab814
https://doi.org/10.1152/ajpcell.1991.260.1.c50
https://doi.org/10.1152/ajpcell.1991.260.1.c50
Publikováno v:
Diabetes. 39:1106-1115
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55c99155e210e5f14c440a06d4cd0fa6
https://doi.org/10.2337/diabetes.39.9.1106
https://doi.org/10.2337/diabetes.39.9.1106
Autor:
J P, Cobb, R S, Hotchkiss, P E, Swanson, K, Chang, Y, Qiu, V E, Laubach, I E, Karl, T G, Buchman
Publikováno v:
Surgery. 126(2)
Nitric oxide (NO) produced by the inducible isoform of NO synthase (iNOS or NOS2) has been implicated in the hypotension, organ failure, and death that complicate sepsis. To avoid the confounding effects and limitations of iNOS inhibitors, we used iN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0535884707da290612e7524c6dc846e9
https://pubmed.ncbi.nlm.nih.gov/10455918
https://pubmed.ncbi.nlm.nih.gov/10455918
Autor:
R S, Hotchkiss, P E, Swanson, C M, Knudson, K C, Chang, J P, Cobb, D F, Osborne, K M, Zollner, T G, Buchman, S J, Korsmeyer, I E, Karl
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(7)
In sepsis there is extensive apoptosis of lymphocytes, which may be beneficial by down-regulating the accompanying inflammation. Alternatively, apoptosis may be detrimental by impairing host defense. We studied whether Bcl-2, a potent antiapoptotic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d303a33fcb7be01b1bc4e2f6ebeedf0
https://pubmed.ncbi.nlm.nih.gov/10201940
https://pubmed.ncbi.nlm.nih.gov/10201940
Autor:
S L, DeMeester, J P, Cobb, R S, Hotchkiss, D F, Osborne, I E, Karl, K W, Tinsley, T G, Buchman
Publikováno v:
Surgery. 124(2)
Apoptosis, a mechanism of cell death prominent in critical illnesses including disseminated inflammation and multiorgan dysfunction syndrome, is characterized by morphologic changes including cell shrinkage, condensation of organelles, blebbing, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a51704c8ea76c14abd17581a8fe931bf
https://pubmed.ncbi.nlm.nih.gov/9706160
https://pubmed.ncbi.nlm.nih.gov/9706160
Autor:
R S, Hotchkiss, I E, Karl
Publikováno v:
New horizons (Baltimore, Md.). 4(1)
Calcium functions as a critical intracellular second messenger and regulates many cellular processes such as muscle contractility, glycogen and protein turnover, hormone secretion, and vascular smooth muscle tone which are markedly abnormal during se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbfa2008dfed9b614225ce8f3a90e9d3
https://pubmed.ncbi.nlm.nih.gov/8689276
https://pubmed.ncbi.nlm.nih.gov/8689276
Publikováno v:
Shock (Augusta, Ga.). 3(5)
Calcium plays an important role in the toxic effects of endotoxin, and calcium antagonists also have been shown to improve survival in animals challenged with endotoxin. Calcium may be involved in regulating cytokine production. Therefore, the protec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5cb9798921e0088f67eac7689242384
https://pubmed.ncbi.nlm.nih.gov/7648334
https://pubmed.ncbi.nlm.nih.gov/7648334
Publikováno v:
The American journal of physiology. 267(3 Pt 2)
In addition to participating in protein synthesis in cells and tissues, L-arginine is essential for the synthesis of urea, creatine, creatinine, nitric oxide, and agmatine and influences hormonal release and the synthesis of pyrimidine bases. This pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b10f611d3f04efc2694554b1b775b2
https://pubmed.ncbi.nlm.nih.gov/8092248
https://pubmed.ncbi.nlm.nih.gov/8092248