Zobrazeno 1 - 10
of 17
pro vyhledávání: '"I D Dukes"'
Autor:
I. D. Dukes, L. H. Philipson
Publikováno v:
Diabetes. 45:845-853
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::584ee7c375aa1d89fe5a6384156ee84f
https://doi.org/10.2337/diabetes.45.7.845
https://doi.org/10.2337/diabetes.45.7.845
Autor:
M E Lancaster, A Kuznetsov, J.F. Worley rd, Louis H. Philipson, M P Rosenberg, M. W. Roe, I D Dukes
Publikováno v:
Journal of Biological Chemistry. 269:27787-27790
Glucose stimulation of pancreatic beta-cell insulin secretion is closely coupled to alterations in ion channel conductances and intracellular Ca2+ ([Ca2+]i). To further examine this relationship after augmentation of voltage-dependent K+ channel expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8d0674a1ab397b825af1058131ad746
https://doi.org/10.1016/s0021-9258(18)46851-2
https://doi.org/10.1016/s0021-9258(18)46851-2
Autor:
L. Cleemann, I. D. Dukes
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 264:E348-E353
Glucose-induced insulin secretion by beta-cells is linked to phasic increases in intracellular Ca2+ concentration ([Ca2+]i) arising from membrane depolarization. We examined the source of this Ca2+in cultured beta-cells using rapid dual-wavelength sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3cc3914fdf4ebfd277de246e0ae924
https://doi.org/10.1152/ajpendo.1993.264.3.e348
https://doi.org/10.1152/ajpendo.1993.264.3.e348
Autor:
Martin Morad, I D Dukes
Publikováno v:
The Journal of Physiology. 435:395-420
1. The transient outward K+ current (Ito) was studied in enzymatically isolated rat ventricular myocytes using the whole-cell patch clamp technique. 2. At holding potentials between -100 and -60 mV, depolarizing pulses activated outward current which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12482de6a052e35c3566d954c1893a45
https://doi.org/10.1113/jphysiol.1991.sp018516
https://doi.org/10.1113/jphysiol.1991.sp018516
Autor:
M W, Roe, J F, Worley, A A, Mittal, A, Kuznetsov, S, DasGupta, R J, Mertz, S M, Witherspoon, N, Blair, M E, Lancaster, M S, McIntyre, W R, Shehee, I D, Dukes, L H, Philipson
Publikováno v:
The Journal of biological chemistry. 271(50)
Voltage-dependent delayed rectifier K+ channels regulate aspects of both stimulus-secretion and excitation-contraction coupling, but assigning specific roles to these channels has proved problematic. Using transgenically derived insulinoma cells (bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::723326b060f01dedebfff1b11c2ad0bc
https://pubmed.ncbi.nlm.nih.gov/8943282
https://pubmed.ncbi.nlm.nih.gov/8943282
Publikováno v:
The Journal of biological chemistry. 271(9)
The energy requirements of most cells supplied with glucose are fulfilled by glycolytic and oxidative metabolism, yielding ATP. In pancreatic beta-cells, a rise in cytosolic ATP is also a critical signaling event, coupling closure of ATP-sensitive K+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a692f3df1e6764563b8e0f2b71e0f50
https://pubmed.ncbi.nlm.nih.gov/8617753
https://pubmed.ncbi.nlm.nih.gov/8617753
Publikováno v:
The Journal of biological chemistry. 269(51)
Glucose stimulation of beta-cell insulin secretion is initiated by membrane depolarization coupled with an elevation in intracellular Ca2+ concentration ([Ca2+]i). Both depolarization-dependent Ca2+ entry and intracellular Ca2+ store release contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d46c6a8442987b46f25185d457bffb0a
https://pubmed.ncbi.nlm.nih.gov/7798198
https://pubmed.ncbi.nlm.nih.gov/7798198
Autor:
L H, Philipson, M P, Rosenberg, A, Kuznetsov, M E, Lancaster, J F, Worley, M W, Roe, I D, Dukes
Publikováno v:
The Journal of biological chemistry. 269(45)
Glucose stimulation of pancreatic beta-cell insulin secretion is closely coupled to alterations in ion channel conductances and intracellular Ca2+ ([Ca2+]i). To further examine this relationship after augmentation of voltage-dependent K+ channel expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b5ea1ff636f43570fa1185ed816a36f
https://pubmed.ncbi.nlm.nih.gov/7961701
https://pubmed.ncbi.nlm.nih.gov/7961701
Autor:
M W, Roe, L H, Philipson, C J, Frangakis, A, Kuznetsov, R J, Mertz, M E, Lancaster, B, Spencer, J F, Worley, I D, Dukes
Publikováno v:
The Journal of biological chemistry. 269(28)
Non-insulin-dependent diabetes mellitus (NIDDM) is a metabolic disease associated with abnormal insulin secretion, the underlying mechanisms of which are unknown. Glucose-dependent signal transduction pathways were investigated in pancreatic islets d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::938efb3a9ea515a48d615e57b5c7b45b
https://pubmed.ncbi.nlm.nih.gov/8034570
https://pubmed.ncbi.nlm.nih.gov/8034570
Publikováno v:
The Journal of biological chemistry. 269(20)
Glucose stimulation of islet beta-cell insulin secretion is initiated by membrane depolarization and an elevation in intracellular free calcium concentration ([Ca2+]i) from a combination of influx through depolarization-activated Ca2+ channels and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c2edf47132977c6595a92c3f1468d7d
https://pubmed.ncbi.nlm.nih.gov/8182038
https://pubmed.ncbi.nlm.nih.gov/8182038