Zobrazeno 1 - 10
of 24
pro vyhledávání: '"I D, Kurzman"'
Publikováno v:
Veterinary and comparative oncology. 14(2)
While maintaining a standard toceranib dosage [2.75 mg kg(-1) , PO, every other day (EOD)], three dose-escalating CCNU cohorts up to and including 60 mg m(-2) , PO, q3wk, were completed. The dose-limiting toxicities (DLT) for the combination were neu
Autor:
Jon J. Ramsey, Ellen B. Roecker, J. Pinheiro, E. G. MacEwen, I. D. Kurzman, Arlene L. M. Haffa, Joseph W. Kemnitz
Publikováno v:
Journal of Medical Primatology. 29:330-337
Cross-sectional studies of humans have shown that dehydroepiandrosterone sulfate (DHEAS) peaks shortly after sexual maturation and declines thereafter, suggesting that the progressive reduction in DHEAS may play a role in the aging process and in the
Publikováno v:
Veterinary Pathology. 37:33-39
Eighty-three canine cutaneous mast cell tumors were graded histologically and evaluated immunohistochemically for p53 tumor-suppressor protein expression. An avidin–biotin immunohistochemical protocol incorporated a rabbit polyclonal antibody (CM-1
Autor:
J F, Borrego, M K, Huelsmeyer, M E, Pinkerton, J L, Muszynski, S A K, Miller, I D, Kurzman, D M, Vail
Publikováno v:
Veterinary and comparative oncology. 14(2)
We interrogated the neurokinin-1 receptor (NK-1R)/substance P (SP) pathway in canine melanoma tumour tissues and cell lines. NK-1R messenger RNA (mRNA) and protein expression were observed in the majority of tumour tissues. Immunohistochemical assess
Publikováno v:
Veterinary and comparative oncology. 13(3)
Amputation and chemotherapy are the mainstay of treatment for canine appendicular osteosarcoma (OSA). In vitro studies have demonstrated anti-tumour activity of pamidronate against canine OSA. The purpose of this study was to assess the safety of add
Autor:
I D Kurzman, E G MacEwen
Publikováno v:
Veterinary Clinics of North America: Small Animal Practice. 26:123-133
Canine osteosarcoma is a highly metastatic cancer commonly seen in large breed dogs. At the time of diagnosis, approximately 90% to 95% of the dogs have established micrometastases. Dogs undergoing amputation alone have a median survival time of 3 to
Autor:
E G MacEwen, I D Kurzman
Publikováno v:
The Journal of Nutrition. 121:S51-S55
It is estimated that 25-50% of pet dogs are overweight. In rodents and humans the adrenal steroid dehydroepiandrosterone (DHEA) has been associated with loss of body weight and reduction in total body fat content. We have shown that administration of
Publikováno v:
Journal of veterinary internal medicine. 14(5)
Sixteen dogs with histologically confirmed appendicular osteosarcoma were treated by amputation followed by cisplatin and doxorubicin chemotherapy. All dogs began chemotherapy within 24 hours of surgery. Cisplatin was administered at 50 mg/m2 intrave
Autor:
E G, MacEwen, I D, Kurzman, D M, Vail, R R, Dubielzig, K, Everlith, B R, Madewell, C O, Rodriguez, B, Phillips, C H, Zwahlen, J, Obradovich, R C, Rosenthal, L E, Fox, M, Rosenberg, C, Henry, J, Fidel
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(12)
Spontaneous canine oral melanoma (COM) is a highly metastatic cancer, resistant to chemotherapy, and can serve as a model for cancer immunotherapy. Liposome-encapsulated muramyl tripeptide-phosphatidylethanolamine (L-MTP-PE) can activate the tumorici
Autor:
A E, Hershey, I D, Kurzman, L J, Forrest, C A, Bohling, M, Stonerook, M E, Placke, A R, Imondi, D M, Vail
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(9)
This study represents part of an effort to determine the safety and efficacy of inhaled antineoplastic drugs, using pet dogs with spontaneously arising primary and metastatic lung cancers (including sarcoma, carcinoma, and malignant melanoma) as a mo