Zobrazeno 1 - 10
of 65
pro vyhledávání: '"I D, Goldberg"'
Publikováno v:
Proceedings of the National Academy of Sciences. 96:3700-3705
A serpin was identified in normal mammary gland by differential cDNA sequencing. In situ hybridization has detected this serpin exclusively in the myoepithelial cells on the normal and noninvasive mammary epithelial side of the basement membrane and
Publikováno v:
International Journal of Radiation Biology. 75:301-316
To investigate the regulation of G1 cyclin-dependent kinase inhibitor p21WAF1/CIP1 by ultraviolet (UV) radiation in human carcinoma cells.Human cancer cell lines were irradiated with UV-C (254 nm) radiation, and their responses were characterized by
Publikováno v:
Cancer research. 61(21)
The cytokine hepatocyte growth factor/scatter factor (HGF/SF) protects epithelial and cancer cells against DNA-damaging agents via a pathway involving signaling from c-Met --phosphatidylinositol-3- kinase --c-Akt. However, the downstream alterations
Publikováno v:
Cancer research. 61(6)
Tissue inhibitors of matrix metalloproteinase (TIMPs) are multifunctional proteins with both matrix metalloproteinase (MMP) inhibitory effects and growth-regulatory activity. TIMPs inhibit MMP activity, suggesting a use for cancer gene therapy. Howev
Publikováno v:
Clinicalexperimental metastasis. 18(2)
Chemically modified tetracyclines (CMTs) are promising anti-cancer agents. In this study, we found that CMT-3 and CMT-8 showed dose-dependent cytotoxicities in MDA-MB-468 human breast cancer cells. Moreover, both CMT-3 and CMT-8 significantly inhibit
Publikováno v:
Cancer research. 60(22)
We previously identified and characterized a novel tumor growth inhibitor and a fatty acid-binding protein in human mammary gland and named it the mammary-derived growth inhibitor-related gene (MRG). Here, the effects of MRG on mammary gland differen
Publikováno v:
Cancer research. 60(20)
Epidemiological studies suggest that moderate alcohol consumption increases the risk of breast cancer, and that alcohol combined with estrogen replacement therapy may synergistically enhance the risk. However, the mechanism(s) of alcohol-induced mamm
Publikováno v:
Cancer investigation. 17(1)
We have provided an overview of recent studies that have greatly expanded our knowledge of the molecular and cellular mechanisms that determine the sensitivity or resistance to ionizing radiation. Much of this knowledge was obtained by studying tumor
Publikováno v:
Oncology (Williston Park, N.Y.). 14(4)
Local tumor recurrence after radiation therapy is due primarily to the failure to eradicate all of the tumor cells within the treatment fields. Theoretically, all cancers could be controlled locally if a sufficiently high radiation dose could be deli
Publikováno v:
The Journal of biological chemistry. 274(51)
Apolipoprotein E (apoE) is known to inhibit cell proliferation; however, the mechanism of this inhibition is not clear. We recently showed that apoE stimulates endothelial production of heparan sulfate (HS) enriched in heparin-like sequences. Because